DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5355 and Prepl

DIOPT Version :9

Sequence 1:	NP_609397.2	Gene:	CG5355 / 34421	FlyBaseID:	FBgn0032242	Length:	756	Species:	Drosophila melanogaster
Sequence 2:	NP_001157094.1	Gene:	Prepl / 213760	MGIID:	2441932	Length:	725	Species:	Mus musculus

Alignment Length:	710	Identity:	165/710 - (23%)
Similarity:	292/710 - (41%)	Gaps:	132/710 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 RPFLENGEEWKKLNTKL--TKLWNYPKYGCPMRYGNYYYYFMNTGLQNQSVMYQQKSLGDESESK 157
            :|..||.:.::|:.|:|  .....|......:::|.:.||      |....:.:.|.  :|::|.
Mouse    82 KPISENMDAFEKVRTRLETQPQEEYEVVNAEIKHGGFVYY------QEGCCLVRSKD--EEADSD 138

  Fly   158 VFLDPNTLSEDGTIALTQK-----AFSEDGKYMAYGLSESGSDWIKILIRDAETG-----KDLSE 212
            .:.....|.|   :.|.|.     ..:.|.||:|          .||...|:||.     |...:
Mouse   139 NYEVLFNLEE---LKLDQPFIDCIRVAPDEKYVA----------AKIRTEDSETSTLVVVKLSDQ 190

  Fly   213 VLEKVKFSEIS---WTKDNKG---FFYG-----RYPDQDGKTDGSETKQNENQKLYYHRVGESQD 266
            .:.:..|..:|   |.||.:.   .||.     |..|....|.| :.|:||.   :|      .:
Mouse   191 PVMEASFPNVSSFEWVKDEEDEDVLFYTFQRNLRCHDVYRATFG-DNKRNER---FY------TE 245

  Fly   267 KDTLVVEFPEEPSWRIQSTVSDCGKYLILAIVKDCRDNIVFYADLTPGAEITSKLNVKKIVEK-F 330
            ||         ||:.:...::...::|.|.|:......:.....|:|       .:...:::| .
Mouse   246 KD---------PSYFVFLYLTKDSRFLTLNIMNKTTSEVWLIDGLSP-------WDPPVLIQKRI 294

  Fly   331 EADYDYITNEGSKIFFRTNKNAP-NYQVIAIDFNNSAEDKWETLIAEHKSDVLDWVKCVDNDKL- 393
            .....|:.:...:::..||...| .::::....:..|...|:......::     .|.||.|..
Mouse   295 HGMLYYVEHRDDELYILTNVGEPTEFKLMRTAADAPAIMNWDLFFTMKRN-----TKVVDLDMFK 354

  Fly   394 --LVCYIRDVKSVLQVN--SLKDGTLLREFDLD---IGTIVGTSGEKKYSEIFYNFSSFLNPGSI 451
              .|.:::. .::|.||  .|.|.: :|...|.   .|.|:.|:.:.|...  :...|.:.|...
Mouse   355 DHCVLFLKH-SNLLYVNVIGLADDS-VRSLKLPPWACGFIMDTNSDPKNCP--FQLCSPIRPPKY 415

  Fly   452 YRYDF-------KTPDKSPSVFREIKLNLEGFRREDYAVEQIFYKSKDGTKVPMFIIRK-KRDSV 508
            |.|.|       :|..:.|.......|.:|.             |||||..|||.:..| ..:.:
Mouse   416 YTYKFAEGKLFEETGHEDPITKTSRVLRIEA-------------KSKDGKLVPMTVFHKTDSEDL 467

  Fly   509 EPRPCLLYGYGGFNISMLPSFGLSGLMFIDTFDG-VLAYPNLRGGGEYGEKWHNGGRLLNKQNVF 572
            :.:|.|::.||.:.:.:..:|.....:.:|  || :|||.::|||||.|.:||..|||..|.|..
Mouse   468 QRKPLLVHVYGAYGMDLKMNFRPEKRVLVD--DGWILAYCHVRGGGELGLQWHADGRLTKKLNGL 530

  Fly   573 DDFQAAAEYLIENKYTTKDRLAIQGGSNGGLLVGSCINQRPDLFGAAVAQVGVMDMLRFHKFT-- 635
            .|..|..:.|....::......:...|.||:|||:..|.:|:|..|...:...:|:|.....|
Mouse   531 ADLVACIKTLHSQGFSQPSLTTLSAFSAGGVLVGALCNSKPELLRAVTLEAPFLDVLNTMLDTTL 595

  Fly   636 -IGHAWCSDYGNP-SEKEHFDNLYKFSPLHNVHTPKGAETEYPSTLILTADHDDRVSPLHSL-KF 697
             :......::||| |:::|.:.:.::.|..|: .|:    .|||..|...::|:|| ||..: .:
Mouse   596 PLTLEELEEWGNPSSDEKHKNYIKRYCPCQNI-KPQ----HYPSVHITAYENDERV-PLKGIVNY 654

  Fly   698 IAALQEAVRD-----SEFQKNPVLLRVYQKAGHGAGKPTSKRIEEATDILTFLSKSLNVD 752
            ...|:|||.:     .|..:.|.::...|..|:...:.:.|:|   |..:.||.:.|.:|
Mouse   655 TEKLKEAVAEHTKGAGEGYQPPNIILDIQPGGNHVIEDSHKKI---TTQMKFLYEELGLD 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5355	NP_609397.2	Peptidase_S9_N	51..467	CDD:280970	82/411 (20%)
		Aes	442..750	CDD:223730	88/326 (27%)
		Peptidase_S9	541..752	CDD:278741	65/221 (29%)
Prepl	NP_001157094.1	PtrB	113..661	CDD:224684	144/624 (23%)
Prepl	NP_001157094.1	Abhydrolase	487..>647	CDD:304388	51/167 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848791
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1505
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740