DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cnot4 and AT2G28540

DIOPT Version :9

Sequence 1:	NP_001260343.1	Gene:	Cnot4 / 34416	FlyBaseID:	FBgn0051716	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_001031437.2	Gene:	AT2G28540 / 817402	AraportID:	AT2G28540	Length:	960	Species:	Arabidopsis thaliana

Alignment Length:	1143	Identity:	269/1143 - (23%)
Similarity:	423/1143 - (37%)	Gaps:	316/1143 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 CPLCMEPLEVDDLTFFPCTCGYQICRFCWHRI--RTDENKL---CPACRKEYPENPADFKPLSQE 72
            ||||.|.:::.|....||.||||||.:|||.|  ..:::|.   |||||..|.:.......:|.|
plant     9 CPLCTEEMDLTDQHLKPCKCGYQICVWCWHHIIEMAEKDKTEGRCPACRTRYDKEKIVGMTVSCE 73

  Fly    73 EMIAFKSQKRQRDQQRKQKITENRKHLANVRVVQKNLVFVVGLPPRLADADILKKHEYFGKYGKI 137
            .::|.....|::.|:.|.|..|.||.|..|||:|:|||:|:.||..|||.|:.::.||||:|||:
plant    74 RLVAEFYIDRKKSQKAKPKPAEGRKDLTGVRVIQRNLVYVMSLPFDLADEDMFQRREYFGQYGKV 138

  Fly   138 HKVVINPSTTYAG-VQVRVGPSASAYVTYVNNSDALRAIQSVNNIMIDGRLIKTSLGTTKYCSHF 201
            .||.:  |.|.|| ||.....:.|.|:||....:|:|.|:||:..::|||.:|...||.|||..:
plant   139 VKVAM--SRTAAGAVQQFPNNTCSVYITYSKEEEAIRCIRSVHGFILDGRNLKACFGTMKYCHAW 201

  Fly   202 MKNQQCPKGDCMYLHELGDPEASFTKEE---MHQGKHLEYEKRLHDTLI----ASLGPNATGIVN 259
            ::|..|...:|:||||:|..|.||:|:|   .|..|.::......|..:    :.|.|.....|:
plant   202 LRNMPCSNAECLYLHEIGAQEDSFSKDETISAHMRKMVQDITGWRDHYVRRSGSMLPPPVDDYVD 266

  Fly   260 GNGASK--ANVAIPSSSSASSSSSGSGTNGSSASGNAQQKEAWPSLSVSPINGKEAAATATSSSG 322
            ...:::  ..|.:.:..||:.:|..:.:|..|.           :|....:.|..::...|.||
plant   267 NESSTRIIPKVVLNNVHSAAKNSPPNDSNSHSV-----------TLPAGAMWGMHSSVPNTPSS- 319

  Fly   323 KSKREKLRNEKRHEKNKAKNKNGSNTNANASNKENYVPETRSSTSTETFAEATADA------PAS 381
               ||.||           :|:.:.::|.|.|     |...||.|.|....|...|      |.|
plant   320 ---REPLR-----------DKSATVSSAVAIN-----PTQISSRSDELRKPALEAAGGNVLKPQS 365

  Fly   382 T---KAEPPQ-ASSNRTRADRGKDRTTASAKEQKKSKEAAPAPAASKPAERVETSESTIRQKKAE 442
            .   |.:.|: :|||:|:....::..:||....:         |.|:|::
plant   366 LLDGKTDFPELSSSNKTQISNSRNVVSASVDNSR---------AISEPSD--------------- 406

  Fly   443 VTESCEDNLPQKRLAGTNVQRSVSSCSENSEGHVSESSLSEKSLTGDYVEEKCNSVNSESQQESV 507
                |.| ||:                     |.|.|  :...:....::..|::|.|......|
plant   407 ----CTD-LPE---------------------HTSLS--NGNKMINRRIQNGCSNVVSVDADSVV 443

  Fly   508 KFQEELEKSNEAIVEAETILPT-AESSEDISPAAVAPGNGEVEGCLPVVDPVEPPSLADNG---- 567
            .....:.:|:::.::..:|.|| .|.|:|.           ::.|  |.:|.|...|..:|
plant   444 DGYHGITRSDKSHIDHASIKPTLTEVSQDY-----------LQRC--VDEPREVQPLQKSGRTNA 495

  Fly   568 ----------SRVTDALSKLNI-----FDDTPSFFTSPSFQQAPILKNKLDLEMRQSHLPDLVND 617
                      :|.|..:|.|..     .:|..|.|.....:...:|..:.:..:|.|:.
plant   496 NEVGVSREEVNRGTSLMSPLGTGHYLEAEDDISLFYRQRLKDPEVLSCQSNGFLRPSNC------ 554

  Fly   618 IDGIQKASNTNEWEEAFKNVMMGNTQHMEEQLLQQQHLQQHQNLRHQLVLQQEEFLRMQELQKRN 682
               :|..|:..:.|......:.|::               :.:.|...:...........|.:.|
plant   555 ---MQPCSSQYKAEHDETRTVFGSS---------------YSDSRGSNIAPISNGYTEMPLSEPN 601

  Fly   683 NFATQINGPANDFL----RAYELRAQANAIIQQQLLQQHAGENLFGGNMSKFFDFHKSQPQSHHQ 743
                |:||..|..:    :|.:.:...|..:..........:.:....||...|.:.:.|   |.
plant   602 ----QLNGSLNHSILVPDKARDTQPIENCFVDSHESPSEIDDRIIANIMSLDLDEYLTSP---HN 659

  Fly   744 YLNGHPPQINGNGAVPEPQRVAASLESNRLNSPFVENGLINSQQQQQQQQQQQKQRMMGMYEFMP 808
            |.|          ...|....|.||:  ..:|..||:   |..:....:|::.|.:....|.  .
plant   660 YAN----------PFGESDEEARSLK--LASSSKVED---NQSRFSFARQEEPKDQAFDSYN--A 707

  Fly   809 PNTQSQQNRFTQNSIVDDDLGFDPFVETQKGLAELMENEVVQKQSINNENPLPKLPPQPQVP--- 870
            .|..|:.|.|.|||..........| .|..||:......:   ..:...:.||.......||
plant   708 SNQMSRGNDFYQNSSERQSPNMGMF-GTYNGLSSCYRRGL---DYVTESSTLPSSYKPTSVPRCP 768

  Fly   871 ---------PHPQLVDNLQRARMPPPGFNHVNTLGLGGASRLQLTSKIIPFMNMPVNGVGNSGAQ 926
                     |.|        :|.|||||:.                          ||
plant   769 VSAPPGFSVPTP--------SRPPPPGFSS--------------------------NG------- 792

  Fly   927 GQHQMPMGVNWNAPMGMHQNPGQPVGDSQLQHPMAHNKVYNNS-------DWTSMDPAILSFRQ- 983
            ..|||..|.:               |:|:....:|:...|..|       |...||||||:..|
plant   793 RDHQMIDGFS---------------GNSRFSDSIAYGNHYQQSLPIENVRDVQYMDPAILAVGQG 842

  Fly   984 ------------------YSSFPQNQIPPHPQQQQDLFLQHLAQQQNSQSGGFN----------- 1019
                              |.|..:.|     ||||...:|:....||..|...|
plant   843 FENASLDFRSNFQGNTNMYGSAAKLQ-----QQQQQAVMQNPLSMQNPLSSHQNCRFTDSLGMAP 902

  Fly  1020 -----NQAQQMLP--MGMPNSLLNGQQTQPPQVNANVQ 1050
                 :|...:|.  |.:||...||..:...|....:|
plant   903 RFIDQSQGNNLLTRNMALPNGHWNGLMSNEIQTRNRLQ 940

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cnot4	NP_001260343.1	zf-RING_4	13..59	CDD:291250	24/50 (48%)
Cnot4	NP_001260343.1	RRM_CNOT4	103..203	CDD:240884	46/100 (46%)
AT2G28540	NP_001031437.2	MOT2	2..>316	CDD:227502	110/319 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	83	1.000	Domainoid score	I2883
eggNOG	1	0.900	-	-		E1_COG5175
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	223	1.000	Inparanoid score	I1183
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002983
OrthoInspector	1	1.000	-	-		otm3149
orthoMCL	1	0.900	-	-		OOG6_102042
Panther	1	1.100	-	-	O	PTHR12603
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1980
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.910