DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cnot4 and cnot4

DIOPT Version :9

Sequence 1:	NP_001260343.1	Gene:	Cnot4 / 34416	FlyBaseID:	FBgn0051716	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	XP_031753832.1	Gene:	cnot4 / 594959	XenbaseID:	XB-GENE-947788	Length:	781	Species:	Xenopus tropicalis

Alignment Length:	975	Identity:	321/975 - (32%)
Similarity:	431/975 - (44%)	Gaps:	318/975 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 DDAVECPLCMEPLEVDDLTFFPCTCGYQICRFCWHRIRTDENKLCPACRKEYPENPADFKPLSQE 72
            :|.|||||||||||:||:.|||||||||||||||||||||||.|||||||.|||:||.:||||||
Frog     9 EDPVECPLCMEPLEIDDINFFPCTCGYQICRFCWHRIRTDENGLCPACRKPYPEDPAVYKPLSQE 73

  Fly    73 EMIAFKSQKRQRDQQRKQKITENRKHLANVRVVQKNLVFVVGLPPRLADADILKKHEYFGKYGKI 137
            |:...|::|:|:..:|||||:|||||||:||||||||||||||..||||.::||:.|||||:|||
Frog    74 ELQRIKNEKKQKQNERKQKISENRKHLASVRVVQKNLVFVVGLSQRLADPEVLKRPEYFGKFGKI 138

  Fly   138 HKVVINPSTTYAGVQVRVGPSASAYVTYVNNSDALRAIQSVNNIMIDGRLIKTSLGTTKYCSHFM 202
            ||||||.||:|||.|   ||||||||||:.:.|||||||.|||:::|||.:|.|||||||||:|:
Frog   139 HKVVINNSTSYAGSQ---GPSASAYVTYIRSEDALRAIQCVNNVVVDGRTLKASLGTTKYCSYFL 200

  Fly   203 KNQQCPKGDCMYLHELGDPEASFTKEEMHQGKHLEYEKRLHDTLIASLGPN----ATGIVNGNGA 263
            ||.||||.||||||||||..||||||||..|||.|||::|...|. .|.||    :||.|:.|
Frog   201 KNMQCPKPDCMYLHELGDEAASFTKEEMQAGKHQEYEQKLLQELY-KLNPNFLQLSTGTVDKN-- 262

  Fly   264 SKANVA------IPSSSSASSSSSGSGTNGSSASGNAQQKEAWPSLSVSPINGKEAAATATSSSG 322
             |..|.      :|                     |:..|:|||||
Frog   263 -KNKVTALQRYDVP---------------------NSNNKDAWPSL------------------- 286

  Fly   323 KSKREKLRNEKRHEKNKAKNKNGSNTNANASNKENYVPETRSSTSTETFAEATADAPASTKAEPP 387
                                 ..||.:||....|:                         :..||
Frog   287 ---------------------QNSNRSANGLGLEH-------------------------RKSPP 305

  Fly   388 QASSNRTRADRGKDRTTASAKEQKKSKEAAPAPAASKPAERVETSESTIRQKKAEVTESCEDNLP 452
                   ..|.|.|                  |....|    :..:|..    ....||.|.|:.
Frog   306 -------ILDNGLD------------------PDHMTP----DGPDSDF----GLFWESAEHNVA 337

  Fly   453 QKRLAGTNVQRSVSSCSENSEGHVSESSLSEKSLTGDYVEEKCNSVNSESQQESVKFQEELEKSN 517
            :                                 .|..:|:..:||:..|:..|:...:.|::
Frog   338 K---------------------------------FGRVIEDDTSSVDKSSESLSIGNGDNLQQ-- 367

  Fly   518 EAIVEAETILPTAESSEDISPAAVAPGNGEVEGCLPVVDPVEPPSLADNGSR--VTDALSK-LNI 579
              |:.::|..|             .||       |...:|..|.|.|::.:|  ..||::: .::
Frog   368 --ILTSDTPSP-------------PPG-------LSKPNPSVPISSANHSARSPFEDAMTESQSL 410

  Fly   580 FDDT---PSFFTS--PSFQQAPILKNKLDLEMRQSHLPDLVNDIDGIQKASNTNEWEEAFKNVMM 639
            |.|.   |:...|  |.|..:|    :...|...:..|..:...:.|..:|:| :|:.||.   .
Frog   411 FSDNFRHPNPIPSGLPPFPSSP----QTSSEWPTAPEPQSLFTSETIPVSSST-DWQAAFG---F 467

  Fly   640 GNTQHMEEQL------LQQQHLQQHQNLRHQLVLQQEEFLRMQELQKRNNFATQINGPANDFLRA 698
            |:::..|:.|      :.::.|.  ..:..:|.:|.:..|....||....... ..||.:.||..
Frog   468 GSSKQQEDDLGFDPFDITRKALA--DLIEKELSVQDQPALSPTSLQNPPPHPA-AKGPGSGFLHP 529

  Fly   699 YELRAQANAI------IQQQL--LQQHAGENLFG--GNMSKF--FDF---------HKSQPQSHH 742
             ...|.||:|      :.|:.  .|..|..|.|.  |..:::  ..|         |.:.|.|:.
Frog   530 -TTAANANSIASTFSVLPQRFPPFQHRAVYNSFSFPGQAARYPWMAFPRNNIMHLNHTANPTSNS 593

  Fly   743 QYLN-GHPPQIN-GNGAVPEPQRVAASLESNRLNSPFVENGL------INSQQQQQQQQQQQKQR 799
            .:|: .||||.| |.|.:..... :.|:|.  ||....::||      ||.             .
Frog   594 NFLDLSHPPQHNTGLGGITVADH-SNSIEG--LNMKEWQDGLRALLPNINI-------------N 642

  Fly   800 MMGMYEFMPPNTQSQQNRFTQNSIVDDDLG--FDPFV------ETQKGLAELMENEVVQKQSINN 856
            ..|:.....||..: .|..|.||:..|..|  .||.:      .|..||           :|:.:
Frog   643 FGGLSNASTPNAPT-SNTATTNSLNWDSSGSWMDPAIISGIPSSTGNGL-----------ESLQD 695

  Fly   857 ENP---LPKLP-------PQPQVPP-HPQLVDNLQRARM---------------------PPPGF 889
            :||   |..|.       |...:|| ||.  :||..|::                     |||||
Frog   696 DNPPHWLKSLQALTEMDGPSSSIPPHHPH--NNLFSAQIPLHRGNWSPYPPPSNPASFHSPPPGF 758

Fly 890 889
Frog 759 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cnot4	NP_001260343.1	zf-RING_4	13..59	CDD:291250	41/45 (91%)
Cnot4	NP_001260343.1	RRM_CNOT4	103..203	CDD:240884	73/99 (74%)
cnot4	XP_031753832.1	MOT2	14..515	CDD:227502	252/693 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	148	1.000	Domainoid score	I4463
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	435	1.000	Inparanoid score	I1648
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002983
OrthoInspector	1	1.000	-	-		oto105018
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4260
SonicParanoid	1	1.000	-	-		X1980
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.080