Protein Alignment Cnot4 and Cnot4

DIOPT Version :10

• Sequence 1: NP_001260343.1
• Gene: Cnot4 / 34416
• FlyBaseID: FBgn0051716
• Length: 1062
• Species: Drosophila melanogaster
• Sequence 2: NP_001397613.1
• Gene: Cnot4 / 53621
• MGIID: 1859026
• Length: 713
• Species: Mus musculus
• Alignment Length: 965
• Identity: 308/965 - (31%)
• Similarity: 395/965 - (40%)
• Gaps: 362/965 - (37%)

  Fly     6 SNDDAVECPLCMEPLEVDDLTFFPCTCGYQICRFCWHRIRTDENKLCPACRKEYPENPADFKPLS 70
            :.:|.|||||||||||:||:.|||||||||||||||||||||||.|||||||.|||:||.:||||
Mouse     7 AKEDPVECPLCMEPLEIDDINFFPCTCGYQICRFCWHRIRTDENGLCPACRKPYPEDPAVYKPLS 71

  Fly    71 QEEMIAFKSQKRQRDQQRKQKITENRKHLANVRVVQKNLVFVVGLPPRLADADILKKHEYFGKYG 135
            |||:...|::|:|:..:|||||:|||||||:||||||||||||||..||||.::||:.|||||:|
Mouse    72 QEELQRIKNEKKQKQNERKQKISENRKHLASVRVVQKNLVFVVGLSQRLADPEVLKRPEYFGKFG 136

  Fly   136 KIHKVVINPSTTYAGVQVRVGPSASAYVTYVNNSDALRAIQSVNNIMIDGRLIKTSLGTTKYCSH 200
            ||||||||.||:|||.|   ||||||||||:.:.|||||||.|||:::|||.:|.|||||||||:
Mouse   137 KIHKVVINNSTSYAGSQ---GPSASAYVTYIRSEDALRAIQCVNNVVVDGRTLKASLGTTKYCSY 198

  Fly   201 FMKNQQCPKGDCMYLHELGDPEASFTKEEMHQGKHLEYEKRLHDTLIASLGPN----ATGIVNGN 261
            |:||.||||.||||||||||..||||||||..|||.|||::|...|. .|.||    :||.|:.|
Mouse   199 FLKNMQCPKPDCMYLHELGDEAASFTKEEMQAGKHQEYEQKLLQELY-KLNPNFLQLSTGSVDKN 262

  Fly   262 GASKANVA------IPSSSSASSSSSGSGTNGSSASGNAQQKEAWPSLS----VSPINGKEAAAT 316
               |..|.      .|....:.|.|.|:|.|....| |:......|.||    |.||
Mouse   263 ---KNKVTPLQRYDTPIDKPSDSLSIGNGDNSQQIS-NSDTPSPPPGLSKSNPVIPI-------- 315

  Fly   317 ATSSSGKSKREKLRNEKRHEKNKAKNKNGSNTNANASNKENY-----VPETRSSTSTETFAEATA 376
              |||..|.|...              .|:.|.:.:...:|:     :|
Mouse   316 --SSSNHSARSPF--------------EGAVTESQSLFSDNFRHPNPIP---------------- 348

  Fly   377 DAPASTKAEPPQASSNRTRADRGKDRTTASAKEQKKSKEAAPAPAASKPAERVETSESTIRQKKA 441
                  ...||..||.:|.:|                ...||.|.:...:|.:..|.||..|...
Mouse   349 ------SGLPPFPSSPQTPSD----------------WPTAPEPQSLFTSETIPVSSSTDWQAAF 391

  Fly   442 EV--TESCEDNL-------PQKRLAGTNVQRSVSSCSENSEGHVSESSLSEKSLTGDYVEEKCNS 497
            ..  ::..||:|       .:|.||                      .|.||.|
Mouse   392 GFGSSKQPEDDLGFDPFDVTRKALA----------------------DLIEKEL----------- 423

  Fly   498 VNSESQQESVKFQEELEKSNEAIVEAETILPTA-ESSEDISPAAVAPGNGEVEGCLPVVDPVEPP 561
                    ||:.|..|.             ||: :::...:..|..||:|.:....|
Mouse   424 --------SVQDQPSLS-------------PTSLQNASSHTTTAKGPGSGFLHSAAP-------- 459

  Fly   562 SLADNGSRVTDALSKLNIFDDTPSFFTSPSFQQAPILKNKLDLEMRQSHLPDLVNDIDGIQKASN 626
                     |:|.|..:.|...|..|  |.|||...:.|......:.:..|
Mouse   460 ---------TNANSLNSTFSVLPQRF--PQFQQHRAVYNSFGFPGQAARYP-------------- 499

  Fly   627 TNEWEEAFKNVMMGNTQHMEEQLLQQQHLQQHQNLRHQLVLQQEEFLRMQELQKRNNFATQINGP 691
               |....:|.:|                  |.|
Mouse   500 ---WMAFPRNSIM------------------HLN------------------------------- 512

  Fly   692 ANDFLRAYELRAQANAIIQQQLLQQHAGENLFGGNMSKFFDFHKSQPQSHHQYLN-GHPPQIN-G 754
                                                      |.:.|.|:..:|: ..|||.| |
Mouse   513 ------------------------------------------HTANPTSNSNFLDLNLPPQHNTG 535

  Fly   755 NGAVPEPQRVAASLESNRLNSPFVENGLINSQQQQQQQQQQQKQRMMGMYEFMP---------PN 810
            .|.:|...           |:..||:  :|.::.|.           |:...:|         ||
Mouse   536 LGGIPIAD-----------NNSSVES--LNMKEWQD-----------GLRALLPNININFGGLPN 576

  Fly   811 TQSQQNRF----TQNSIVDDDLGF-------DPFVETQKGLAELMENEVVQKQSINNENP---LP 861
            :.|..|..    |.|:...|.:.:       ||.:.|  |:.....|.:   .||.::||   |.
Mouse   577 SSSPSNANHSAPTSNTATTDSVSWDSPGSWTDPAIIT--GIPASSGNTL---DSIQDDNPPHWLK 636

  Fly   862 KL--------------------PPQPQVP-------PHPQLVDNLQRARMPPPGF 889
            .|                    |...|:|       |:|. ..|......|||||
Mouse   637 SLQALTEMDGPSAASSQPHHSAPFSTQIPLHRASWNPYPP-PSNPSSFHSPPPGF 690

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cnot4	NP_001260343.1	MOT2	5..>235	CDD:227502	170/228 (75%)
		cwf18	312..>386	CDD:462423	9/78 (12%)
Cnot4	NP_001397613.1	MOT2	14..>322	CDD:227502	198/321 (62%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	256..370		29/128 (23%)
		Atrophin-1	<291..>385	CDD:460830	17/102 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	424..459		10/43 (23%)