DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cnot4 and CNOT4

DIOPT Version :9

Sequence 1:	NP_001260343.1	Gene:	Cnot4 / 34416	FlyBaseID:	FBgn0051716	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_001177779.1	Gene:	CNOT4 / 4850	HGNCID:	7880	Length:	713	Species:	Homo sapiens

Alignment Length:	965	Identity:	310/965 - (32%)
Similarity:	396/965 - (41%)	Gaps:	362/965 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SNDDAVECPLCMEPLEVDDLTFFPCTCGYQICRFCWHRIRTDENKLCPACRKEYPENPADFKPLS 70
            :.:|.|||||||||||:||:.|||||||||||||||||||||||.|||||||.|||:||.:||||
Human     7 AKEDPVECPLCMEPLEIDDINFFPCTCGYQICRFCWHRIRTDENGLCPACRKPYPEDPAVYKPLS 71

  Fly    71 QEEMIAFKSQKRQRDQQRKQKITENRKHLANVRVVQKNLVFVVGLPPRLADADILKKHEYFGKYG 135
            |||:...|::|:|:..:|||||:|||||||:||||||||||||||..||||.::||:.|||||:|
Human    72 QEELQRIKNEKKQKQNERKQKISENRKHLASVRVVQKNLVFVVGLSQRLADPEVLKRPEYFGKFG 136

  Fly   136 KIHKVVINPSTTYAGVQVRVGPSASAYVTYVNNSDALRAIQSVNNIMIDGRLIKTSLGTTKYCSH 200
            ||||||||.||:|||.|   ||||||||||:.:.|||||||.|||:::|||.:|.|||||||||:
Human   137 KIHKVVINNSTSYAGSQ---GPSASAYVTYIRSEDALRAIQCVNNVVVDGRTLKASLGTTKYCSY 198

  Fly   201 FMKNQQCPKGDCMYLHELGDPEASFTKEEMHQGKHLEYEKRLHDTLIASLGPN----ATGIVNGN 261
            |:||.||||.||||||||||..||||||||..|||.|||::|...|. .|.||    :||.|:.|
Human   199 FLKNMQCPKPDCMYLHELGDEAASFTKEEMQAGKHQEYEQKLLQELY-KLNPNFLQLSTGSVDKN 262

  Fly   262 GASKANVA------IPSSSSASSSSSGSGTNGSSASGNAQQKEAWPSLS----VSPINGKEAAAT 316
               |..|.      .|....:.|.|.|:|.|....| |:......|.||    |.||
Human   263 ---KNKVTPLQRYDTPIDKPSDSLSIGNGDNSQQIS-NSDTPSPPPGLSKSNPVIPI-------- 315

  Fly   317 ATSSSGKSKREKLRNEKRHEKNKAKNKNGSNTNANASNKENY-----VPETRSSTSTETFAEATA 376
              |||..|.|...              .|:.|.:.:...:|:     :|
Human   316 --SSSNHSARSPF--------------EGAVTESQSLFSDNFRHPNPIP---------------- 348

  Fly   377 DAPASTKAEPPQASSNRTRADRGKDRTTASAKEQKKSKEAAPAPAASKPAERVETSESTIRQKKA 441
                  ...||..||.:|.:|                ...||.|.:...:|.:..|.||..|...
Human   349 ------SGLPPFPSSPQTSSD----------------WPTAPEPQSLFTSETIPVSSSTDWQAAF 391

  Fly   442 EV--TESCEDNL-------PQKRLAGTNVQRSVSSCSENSEGHVSESSLSEKSLTGDYVEEKCNS 497
            ..  ::..||:|       .:|.||                      .|.||.|
Human   392 GFGSSKQPEDDLGFDPFDVTRKALA----------------------DLIEKEL----------- 423

  Fly   498 VNSESQQESVKFQEELEKSNEAIVEAETILPTA-ESSEDISPAAVAPGNGEVEGCLPVVDPVEPP 561
                    ||:.|..|.             ||: ::|...:..|..||:|.:.           |
Human   424 --------SVQDQPSLS-------------PTSLQNSSSHTTTAKGPGSGFLH-----------P 456

  Fly   562 SLADNGSRVTDALSKLNIFDDTPSFFTSPSFQQAPILKNKLDLEMRQSHLPDLVNDIDGIQKASN 626
            :.|.|.:.:....|.|      |..|  |.|||...:.|......:.:..|
Human   457 AAATNANSLNSTFSVL------PQRF--PQFQQHRAVYNSFSFPGQAARYP-------------- 499

  Fly   627 TNEWEEAFKNVMMGNTQHMEEQLLQQQHLQQHQNLRHQLVLQQEEFLRMQELQKRNNFATQINGP 691
               |....:|.:|                  |.|
Human   500 ---WMAFPRNSIM------------------HLN------------------------------- 512

  Fly   692 ANDFLRAYELRAQANAIIQQQLLQQHAGENLFGGNMSKFFDFHKSQPQSHHQYLN-GHPPQIN-G 754
                                                      |.:.|.|:..:|: ..|||.| |
Human   513 ------------------------------------------HTANPTSNSNFLDLNLPPQHNTG 535

  Fly   755 NGAVPEPQRVAASLESNRLNSPFVENGLINSQQQQQQQQQQQKQRMMGMYEFMP---------PN 810
            .|.:|...           ||..||:  :|.::.|.           |:...:|         ||
Human   536 LGGIPVAD-----------NSSSVES--LNMKEWQD-----------GLRALLPNININFGGLPN 576

  Fly   811 TQSQQNRF----TQNSIVDDDLGF-------DPFVETQKGLAELMENEVVQKQSINNENP---LP 861
            :.|..|..    |.|:...|.|.:       ||.:.|  |:.....|.:   .|:.::||   |.
Human   577 SSSPSNANHSAPTSNTATTDSLSWDSPGSWTDPAIIT--GIPASSGNSL---DSLQDDNPPHWLK 636

  Fly   862 KL--------------------PPQPQVP-------PHPQLVDNLQRARMPPPGF 889
            .|                    |...|:|       |:|. ..|......|||||
Human   637 SLQALTEMDGPSAAPSQTHHSAPFSTQIPLHRASWNPYPP-PSNPSSFHSPPPGF 690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cnot4	NP_001260343.1	zf-RING_4	13..59	CDD:291250	41/45 (91%)
Cnot4	NP_001260343.1	RRM_CNOT4	103..203	CDD:240884	73/99 (74%)
CNOT4	NP_001177779.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	424..458		12/57 (21%)
		MOT2	14..>322	CDD:227502	200/325 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	256..372		38/181 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159488
Domainoid	1	1.000	142	1.000	Domainoid score	I4700
eggNOG	1	0.900	-	-		E1_COG5175
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	430	1.000	Inparanoid score	I1732
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002983
OrthoInspector	1	1.000	-	-		oto91242
orthoMCL	1	0.900	-	-		OOG6_102042
Panther	1	1.100	-	-	LDO	PTHR12603
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4260
SonicParanoid	1	1.000	-	-		X1980
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.780