DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cnot4 and cnot4b

DIOPT Version :9

Sequence 1:	NP_001260343.1	Gene:	Cnot4 / 34416	FlyBaseID:	FBgn0051716	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_957463.1	Gene:	cnot4b / 394144	ZFINID:	ZDB-GENE-040426-1164	Length:	798	Species:	Danio rerio

Alignment Length:	1075	Identity:	320/1075 - (29%)
Similarity:	407/1075 - (37%)	Gaps:	441/1075 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 DDAVECPLCMEPLEVDDLTFFPCTCGYQICRFCWHRIRTDENKLCPACRKEYPENPADFKPLSQE 72
            :|.:||||||||||:||:.|||||||||||||||||||||||.|||||||.|||:||.:||||||
Zfish     9 EDPMECPLCMEPLEIDDVNFFPCTCGYQICRFCWHRIRTDENGLCPACRKPYPEDPAVYKPLSQE 73

  Fly    73 EMIAFKSQKRQRDQQRKQKITENRKHLANVRVVQKNLVFVVGLPPRLADADILKKHEYFGKYGKI 137
            |:...|::|:|:..:||||||||||||::|||||:||||||||..||||.::||:.|||||:|||
Zfish    74 ELQRIKNEKKQKQNERKQKITENRKHLSSVRVVQRNLVFVVGLSQRLADPEVLKRPEYFGKFGKI 138

  Fly   138 HKVVINPSTTYAGVQVRVGPSASAYVTYVNNSDALRAIQSVNNIMIDGRLIKTSLGTTKYCSHFM 202
            ||||||.||:|||.|   ||||||||||:.:.|||||||.|||:::|||.:|.|||||||||:|:
Zfish   139 HKVVINNSTSYAGSQ---GPSASAYVTYIRSEDALRAIQCVNNVVVDGRTLKASLGTTKYCSYFL 200

  Fly   203 KNQQCPKGDCMYLHELGDPEASFTKEEMHQGKHLEYEKRLHDTLIASLGPNATGIVNGNGASKAN 267
            |:.||||.||||||||||..||||||||..|||.|||::|...|..: .||..
Zfish   201 KSMQCPKPDCMYLHELGDEAASFTKEEMQAGKHQEYEQKLLQELYKT-NPNFL------------ 252

  Fly   268 VAIPSSSSASSSSSGSG-----TNGSSASGNAQQKEAWPSLSVSPINGKEAAATATSSSGKSKRE 327
                      .||:|:|     .:|:|.|.|:..|||||||.          .|....:|.|:..
Zfish   253 ----------QSSTGTGEKTKSKSGTSQSSNSNSKEAWPSLQ----------TTGKMPNGLSEHH 297

  Fly   328 KLRNEKRHEKNKAKNKNGSNTNANASNKENYVPETRSSTSTETFAEATADAPASTKAEPPQASSN 392
            |                                                        .||
Zfish   298 K--------------------------------------------------------TPP----- 301

  Fly   393 RTRADRGKDRTTASAKEQKKSKEAAPAPAASKPAERVETSESTIRQKKAEVTESCEDNLPQKRLA 457
               .|.|.|
Zfish   302 ---LDGGSD-------------------------------------------------------- 307

  Fly   458 GTNVQRSVSSCSENSEGHVSESSLSEKSLTGDYVEEKCNSVNSESQQESVKFQEELEKSNEAIVE 522
                       |||......:|.|...|:||      ..|..|                     .
Zfish   308 -----------SENMTPDGLDSDLGLGSITG------LPSFTS---------------------N 334

  Fly   523 AETILPTAESSEDISPAAVAPGNGEVEGCLPVVDPVEPPSLADNGSRVTDALSKLNIFDDTPSFF 587
            .|.:.||::.|:.||.:     |||.........|..||.|:.....|.:.::.|.:
Zfish   335 CEPVSPTSKPSDSISLS-----NGETSQISGNDSPSPPPGLSKPSLVVPNCVAGLTV-------- 386

  Fly   588 TSPSFQQAPILKNKLDLEMRQSHLPDLVNDIDGIQKASNTNEWEEAFKNVMMGNTQHMEEQLLQQ 652
            .|| |:.|.                                                .|.|.|
Zfish   387 RSP-FEGAA------------------------------------------------AESQSL-- 400

  Fly   653 QHLQQHQNLRHQLVLQQEEFLRMQELQKRNNFATQINGPANDFLRAYELRAQANAIIQQQLLQQH 717
              ...:.|.||
Zfish   401 --FSDNSNFRH------------------------------------------------------ 409

  Fly   718 AGENLFGGNMSKFFDFHKSQPQSHHQYLNGHPPQINGNG---AVPEPQRVAAS-----LESNRLN 774
                                |......|.|.|..::.|.   ..||||.:..|     ..|....
Zfish   410 --------------------PNPIPSGLPGFPNSLHNNSDWPTAPEPQSLFTSDTIPVSSSTDWQ 454

  Fly   775 SPFVENGLINSQQQQQQQQQQQKQRMMGMYEFMPPNTQSQQNRFTQNSIVDDDLGFDPFVETQKG 839
            :.|   |..:|.:||                                   |||||||||..|:|.
Zfish   455 AAF---GFGSSTKQQ-----------------------------------DDDLGFDPFDVTRKA 481

  Fly   840 LAELMENEVVQKQSINNENPLPKLPPQPQVPPHPQLVDNLQRA-----RMPPPGFNHVNTLGLGG 899
            ||:|:|||:..:.|.    |:......| |.||..|:..|..|     .:.||..:|.
Zfish   482 LADLIENELTVEDSF----PMTITKSAP-VMPHGPLLGPLHNAPSMKSPLQPPTSSHF------- 534

  Fly   900 ASRLQLTSKIIPFMNMPVNGVGNS-GAQGQHQMPMGVNWNAPMGMHQNPGQPVGDSQLQHPMAHN 963
            |....|.|:  .|.::|...|.|| ...||.|.... :|   |||               ||.:|
Zfish   535 APNSSLPSR--GFSHLPHRTVYNSFSFPGQAQSSRH-SW---MGM---------------PMRNN 578

  Fly   964 KVYNNSDWTSMDPAILSFRQYSSFPQNQIPPHPQQQQDLFLQHLAQQQNSQS------GGFNNQA 1022
            ..:.|.   |..|:  |..|:|||....:.|..|......|..:...:||.|      ..:.:..
Zfish   579 LPHLNH---STGPS--SAAQHSSFLDLNLAPQQQHHHSTGLGGIHMTENSTSVESLNVKEWQDGL 638

  Fly  1023 QQMLPM------GMPNSLLNGQQTQPPQVNANVQG 1051
            :.:||.      |:|||..:...:.....:.|..|
Zfish   639 RALLPNININFGGLPNSSSSSSSSSSSSSSMNHTG 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cnot4	NP_001260343.1	zf-RING_4	13..59	CDD:291250	41/45 (91%)
Cnot4	NP_001260343.1	RRM_CNOT4	103..203	CDD:240884	72/99 (73%)
cnot4b	NP_957463.1	MOT2	9..>348	CDD:227502	214/532 (40%)
		zf-RING_4	14..60	CDD:291250	41/45 (91%)
		RRM_CNOT4	104..201	CDD:240884	72/99 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595667
Domainoid	1	1.000	153	1.000	Domainoid score	I4255
eggNOG	1	0.900	-	-		E1_COG5175
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	438	1.000	Inparanoid score	I1647
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002983
OrthoInspector	1	1.000	-	-		otm24663
orthoMCL	1	0.900	-	-		OOG6_102042
Panther	1	1.100	-	-	LDO	PTHR12603
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4260
SonicParanoid	1	1.000	-	-		X1980
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.780