DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cnot4 and ntl-4

DIOPT Version :9

Sequence 1:	NP_001260343.1	Gene:	Cnot4 / 34416	FlyBaseID:	FBgn0051716	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_001294151.1	Gene:	ntl-4 / 177580	WormBaseID:	WBGene00003827	Length:	798	Species:	Caenorhabditis elegans

Alignment Length:	1007	Identity:	297/1007 - (29%)
Similarity:	434/1007 - (43%)	Gaps:	250/1007 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ECPLCMEPLEVDDLTFFPCTCGYQICRFCWHRIRTDENKLCPACRKEYPENPADFKPLSQEEMIA 76
            |||||||.||:||:.|:||.|.||||||||||||||||.||||||:.|||:|.:|||::.:::..
Worm    12 ECPLCMETLELDDINFYPCKCEYQICRFCWHRIRTDENGLCPACRQPYPEDPVNFKPMTTDDVRK 76

  Fly    77 FKSQKRQRDQQRKQKITENRKHLANVRVVQKNLVFVVGLPPRLADADILKKHEYFGKYGKIHKVV 141
            .|.::|.:.|..|.|:::.|::|.|.||:|||||:||||.||:||.:||||:||||:||||.|:|
Worm    77 HKDEQRLKKQAEKLKLSDARQYLCNYRVLQKNLVYVVGLSPRVADPEILKKNEYFGRYGKIQKIV 141

  Fly   142 INPSTTYAGVQVRVGPSASAYVTYVNNSDALRAIQSVNNIMIDGRLIKTSLGTTKYCSHFMKNQQ 206
              .|.|.:.....:.||.:|||||....|||||||.|:|.|:||||:|.|||||||||.|:.:::
Worm   142 --TSATPSLPAPHLPPSHTAYVTYKRVDDALRAIQGVHNSMLDGRLVKASLGTTKYCSSFLNSRK 204

  Fly   207 C--PKGDCMYLHELGDPEASFTKEEMHQGKHLEYEKRLHDTLIASLGPNATGIVNGNGASKANVA 269
            |  |.|:||||||..:.|.||||::||.|||.||||||.:::.:...|
Worm   205 CFKPVGECMYLHENAEAEISFTKDDMHLGKHTEYEKRLIESMNSRPPP----------------- 252

  Fly   270 IPSSSSASSSSSGSGTNGSSASGNAQQKEAWPSLSVSPINGKEAAATATSSSGKSKREKLRNEKR 334
             |.|:.||...                              |..|.|:     .|.|..|.::.
Worm   253 -PQSTLASQLD------------------------------KILAPTS-----NSPRRYLEDDS- 280

  Fly   335 HEKNKAKNKNGSNTNANASNKENYVPETRSSTSTETFAEATADAPASTKAEPPQASSNRTRADRG 399
             :......:.||..:..|.:     |:...:.||.|.......||::    |...:.|..|:::
Worm   281 -DTVDDVERTGSAIHMCADD-----PDDDDADSTNTSNSIDDPAPSN----PADETVNSRRSNQ- 334

  Fly   400 KDRTTASAKEQKKSKEAAPAPAASKPAE----RVETSESTIRQKKAEVTESCEDNLPQKRLAGTN 460
                ||..::..:..|.:.||:.:.|.:    ..|..|...|...:::....:.|  ..|||.|
Worm   335 ----TARERQWSERDEISVAPSNTPPTDPEGNENEFEEDIHRNDVSDLMSKLDVN--DDRLART- 392

  Fly   461 VQRSVSSCSENSEGHVSESSLSEKSLTGDYVEEKCNSVNSESQQESVKFQEELEKSN----EAIV 521
                  |.|||                 ||:.....:.:.|:....::::..|..|:    ..||
Worm   393 ------SFSEN-----------------DYLGIPAPAKHQEAPAPLMQWEALLGLSSPSAQSTIV 434

  Fly   522 EAETILPTAESSEDISPAAVAPGNGEVEGCLPVV--DPVEPPSLADNGSRVTDALSKLNIFDDTP 584
            |..::.||.:.....:..::.   |......|..  :...||.||...|            ||..
Worm   435 EPSSLFPTFKMDSGFNSQSLF---GTHTSSTPSFRREASPPPGLARFNS------------DDDL 484

  Fly   585 SF--FTSPSFQQAPILKNKLDLEMRQSHLPDLVNDIDGIQKASNTNEWEEAFKNVMMGNTQHMEE 647
            .|  ||..|...:.:|:.  :.|....|.....:.:|.::.:....:..|..::... :.||::.
Worm   485 GFDPFTESSKGLSALLQE--EQEQIPPHNSASNHTLDVLKHSRLFGQLPEQRQSTQQ-HPQHLQS 546

  Fly   648 QLLQQQH-LQQHQNLRHQLVLQQEEFLRMQELQKRNNFATQINGPANDFLRAYELRAQANAIIQQ 711
            .  .||| |||:|:..|..:.|    |..|:..::..||..:| ...|::.:..:..|     ||
Worm   547 S--HQQHPLQQNQDQHHSFLHQ----LHAQQQHQQQQFAADMN-RQQDYMYSRLMSQQ-----QQ 599

  Fly   712 QLLQQHAGENLFGGNMSKFFDFHKSQPQSHHQYLNGHPPQINGNGAVPEPQRVAASLESNRLNSP 776
            |..||...::..|  .|..|...:.|.||..|                 .|..:.|.:|:.|
Worm   600 QSQQQRQFDSTPG--FSHPFGSMQQQQQSSQQ-----------------QQHQSQSSQSSSL--- 642

  Fly   777 FVENGLINSQQQQQQQQQQQKQRMMGMYEFMPPNTQSQQNRFTQNSIVDDDLGFDPFVETQKGLA 841
              ...|.|.||||.|.|||.:|.            |.||                    ...|:.
Worm   643 --LQDLFNRQQQQHQAQQQAQQH------------QQQQ--------------------MYAGIN 673

  Fly   842 ELMENEVVQKQSINNENPLPKLPPQPQVPPHPQLVDNLQRARMPPPGFNHVNTLGLGGAS--RLQ 904
            ..|.|:::                .|:||          ....|||        ||||.|  |..
Worm   674 SYMYNDML----------------MPRVP----------FGMAPPP--------GLGGPSTNRSS 704

  Fly   905 LTSKIIPFMNMPVNGVGNSGAQGQHQMPMGVNWNAPMGMHQNPGQPVGDSQLQHPMAHNKVYN-- 967
            .|.:..|.|...     :...|.|.|..||:   ..||.||:..|   |.|.|.|.:....:.
Worm   705 TTQQAPPHMTQQ-----SQQQQQQQQSSMGL---FGMGGHQSMMQ---DHQSQQPQSAQDAFKAL 758

  Fly   968 --NSDWTSMDPAILS-FRQYSSFPQNQIPPHP 996
              |.:...||...:| :...:|...:.:||.|
Worm   759 LPNVNVRFMDDNSMSRWSHENSLRSSAVPPPP 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cnot4	NP_001260343.1	zf-RING_4	13..59	CDD:291250	36/45 (80%)
Cnot4	NP_001260343.1	RRM_CNOT4	103..203	CDD:240884	63/99 (64%)
ntl-4	NP_001294151.1	zf-RING_4	13..59	CDD:291250	36/45 (80%)
ntl-4	NP_001294151.1	RRM_CNOT4	103..201	CDD:240884	63/99 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157533
Domainoid	1	1.000	124	1.000	Domainoid score	I3445
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	345	1.000	Inparanoid score	I1369
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002983
OrthoInspector	1	1.000	-	-		oto18534
orthoMCL	1	0.900	-	-		OOG6_102042
Panther	1	1.100	-	-	LDO	PTHR12603
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4260
SonicParanoid	1	1.000	-	-		X1980
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.010