DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mdh1 and LDHAL6B

DIOPT Version :9

Sequence 1:	NP_001285803.1	Gene:	Mdh1 / 34414	FlyBaseID:	FBgn0262782	Length:	337	Species:	Drosophila melanogaster
Sequence 2:	NP_149972.1	Gene:	LDHAL6B / 92483	HGNCID:	21481	Length:	381	Species:	Homo sapiens

Alignment Length:	191	Identity:	43/191 - (22%)
Similarity:	73/191 - (38%)	Gaps:	16/191 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IRVVVTGAAGQ-IAYSLLYMIARGEVFGKDQPIVLHLLDIPPMVGVLEGVVMELA-DCALPLLVE 67
            :.::.||:.|. .|.|:|......|         |.|:|:..  ..|:|..|:|. ......:..
Human    72 VSIIGTGSVGMACAISILLKGLSDE---------LALVDLDE--DKLKGETMDLQHGSPFTKMPN 125

  Fly    68 VVPTTDPAVGFKDVSAAFLVGAMPRKEGMERKDLLSANVKIFRTQGQALDKFAKKDVKVLVVGNP 132
            :|.:.|..|...........||...| |..|.:|:..||.||:....::.::: ...|:::|.||
Human   126 IVCSKDYFVTANSNLVIITAGARQEK-GETRLNLVQRNVAIFKLMISSIVQYS-PHCKLIIVSNP 188

  Fly   133 ANTNALVCSSYAPSIPRENFSAMTRLDQNRATSQIAAKLGVPISAVKNIIIWGNHSSTQYP 193
            .:....|....:.........:...||..|....|..|||:...:....|: |.|..:..|
Human   189 VDILTYVAWKLSAFPKNRIIGSGCNLDTARFRFLIGQKLGIHSESCHGWIL-GEHGDSSVP 248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdh1	NP_001285803.1	MDH_cytoplasmic_cytosolic	3..327	CDD:133421	43/191 (23%)
Mdh1	NP_001285803.1	MDH_euk_cyt	6..328	CDD:130819	43/190 (23%)
LDHAL6B	NP_149972.1	LDH_1	68..376	CDD:133429	43/191 (23%)
LDHAL6B	NP_149972.1	L-LDH-NAD	74..374	CDD:273796	43/189 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810