DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mdh1 and c-NAD-MDH1

DIOPT Version :9

Sequence 1:	NP_001285803.1	Gene:	Mdh1 / 34414	FlyBaseID:	FBgn0262782	Length:	337	Species:	Drosophila melanogaster
Sequence 2:	NP_171936.1	Gene:	c-NAD-MDH1 / 839527	AraportID:	AT1G04410	Length:	332	Species:	Arabidopsis thaliana

Alignment Length:	328	Identity:	187/328 - (57%)
Similarity:	237/328 - (72%)	Gaps:	0/328 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EPIRVVVTGAAGQIAYSLLYMIARGEVFGKDQPIVLHLLDIPPMVGVLEGVVMELADCALPLLVE 67
            ||:||:||||||||.|:|:.|||||.:.|.|||::||:|||||....|.||.|||.|.|.|||..
plant     4 EPVRVLVTGAAGQIGYALVPMIARGIMLGADQPVILHMLDIPPAAEALNGVKMELIDAAFPLLKG 68

  Fly    68 VVPTTDPAVGFKDVSAAFLVGAMPRKEGMERKDLLSANVKIFRTQGQALDKFAKKDVKVLVVGNP 132
            ||.|||...|...|:.|.:||..||||||||||::|.||.|:::|..||:|.|..:.|||||.||
plant    69 VVATTDAVEGCTGVNVAVMVGGFPRKEGMERKDVMSKNVSIYKSQAAALEKHAAPNCKVLVVANP 133

  Fly   133 ANTNALVCSSYAPSIPRENFSAMTRLDQNRATSQIAAKLGVPISAVKNIIIWGNHSSTQYPDAGQ 197
            ||||||:...:|||||.:|.|.:||||.|||..||:.:|.||:|.|||:||||||||:||||...
plant   134 ANTNALILKEFAPSIPEKNISCLTRLDHNRALGQISERLSVPVSDVKNVIIWGNHSSSQYPDVNH 198

  Fly   198 AKVTANGTVKSVVDAINDNGYLQGSFVETVQKRGAAVIAARKMSSAMSAAKAACDHMHDWWNGTA 262
            |||..:...|.|.:.:.|:.:|.|.|:.|||:||||:|.|||:|||:|||.:||||:.||..||.
plant   199 AKVQTSSGEKPVRELVKDDAWLDGEFISTVQQRGAAIIKARKLSSALSAASSACDHIRDWVLGTP 263

  Fly   263 PGQFVSMGVFSDGSYDSPKDVIFSFPVEIKNKQWKIVSGLTLSDFAKTKLSVTGKELQEEKDEAL 327
            .|.||||||:|||||..|..:|:||||..:|..|.||.||.:.:.::.|:.:|.:||:||||.|.
plant   264 EGTFVSMGVYSDGSYSVPSGLIYSFPVTCRNGDWSIVQGLPIDEVSRKKMDLTAEELKEEKDLAY 328

  Fly   328 SVL 330
            |.|
plant   329 SCL 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdh1	NP_001285803.1	MDH_cytoplasmic_cytosolic	3..327	CDD:133421	184/323 (57%)
Mdh1	NP_001285803.1	MDH_euk_cyt	6..328	CDD:130819	183/321 (57%)
c-NAD-MDH1	NP_171936.1	PLN00135	24..332	CDD:177744	173/308 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	202	1.000	Domainoid score	I860
eggNOG	1	0.900	-	-		E1_COG0039
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4324
Inparanoid	1	1.050	381	1.000	Inparanoid score	I531
OMA	1	1.010	-	-		QHG53893
OrthoDB	1	1.010	-	-		D1118998at2759
OrthoFinder	1	1.000	-	-		FOG0004059
OrthoInspector	1	1.000	-	-		otm3518
orthoMCL	1	0.900	-	-		OOG6_101066
Panther	1	1.100	-	-	O	PTHR23382
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2809
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840