DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdh1 and Uevld

DIOPT Version :9

Sequence 1:	NP_001285803.1	Gene:	Mdh1 / 34414	FlyBaseID:	FBgn0262782	Length:	337	Species:	Drosophila melanogaster
Sequence 2:	XP_008757683.1	Gene:	Uevld / 691172	RGDID:	1587416	Length:	470	Species:	Rattus norvegicus

Alignment Length:	342	Identity:	69/342 - (20%)
Similarity:	120/342 - (35%)	Gaps:	67/342 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PIRVVVTGAAGQIAYSLLYMIARGEVFGKDQPIVLHLLDIPPMVGVLEGVVMELADCALPLLVEV 68
            |.::.|.|:........|.:.|:|..   |:.::|.|.|     |..:| .|:|....|| .||:
  Rat   182 PNKITVVGSGDLGIACTLAISAKGIA---DKLLLLDLSD-----GTNQG-TMDLDIFNLP-NVEI 236

  Fly    69 VPTTDPAVGFKDVSAA-------FLVGAMPRKEGMERKDLLSANVKIFRTQGQALDKFAKKDVKV 126
                     .||:||:       |...::...|..  ...:.:||.:||....||..:::..| :
  Rat   237 ---------SKDLSASAHSKVVIFTANSLGGSESY--LHAVQSNVDMFRALVPALGHYSQHAV-L 289

  Fly   127 LVVGNPANTNALVCSSYAPSIPRENFSAMTRLDQNRATSQIAAKLGVPISAVKNIIIWGNHSSTQ 191
            ||...|....:.|....:.............||..|....|::.|....|. |.:.:.|
  Rat   290 LVASQPVEIMSYVTWKLSTFPAARVMGIGCNLDSQRLQYIISSVLKAQTSG-KEVWVVG------ 347

  Fly   192 YPDAGQAKVTA-NGTVKSVVDAINDNGYLQGSFVETVQKRGAAVIAARKMSSAMSAAKAACDHMH 255
              :.|:.||.: :|          .:|.:..|....:..|...::..:...| .|...:..|.:.
  Rat   348 --EQGENKVCSWSG----------QDGVMSPSSQAQLSSRAMGLLKVKGQRS-WSVGLSVADLLD 399

  Fly   256 DWWNGTAPGQFVSMGVFSDGSYDSPKDVIFSFPVEIKNKQWKIVSGLTLSDFAKTKLSVTGKELQ 320
            ...|...  :..|:...:.|.|....:|..|.|.        |:....:|:..||       ..:
  Rat   400 TIINNKK--KVHSVSTLAKGYYGLDNEVFLSLPC--------ILGTSGVSEVLKT-------AAE 447

  Fly   321 EEKDEALSVLDSNVSNL 337
            :...|||....|::..|
  Rat   448 DAVTEALQTSASSIHGL 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdh1	NP_001285803.1	MDH_cytoplasmic_cytosolic	3..327	CDD:133421	65/330 (20%)
Mdh1	NP_001285803.1	MDH_euk_cyt	6..328	CDD:130819	65/329 (20%)
Uevld	XP_008757683.1	UEV	21..138	CDD:283415
		NADB_Rossmann	180..467	CDD:304358	69/342 (20%)
		L-LDH-NAD	187..461	CDD:273796	67/332 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900