DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mdh1 and UEVLD

DIOPT Version :9

Sequence 1:	NP_001285803.1	Gene:	Mdh1 / 34414	FlyBaseID:	FBgn0262782	Length:	337	Species:	Drosophila melanogaster
Sequence 2:	NP_001035787.1	Gene:	UEVLD / 55293	HGNCID:	30866	Length:	471	Species:	Homo sapiens

Alignment Length:	341	Identity:	73/341 - (21%)
Similarity:	122/341 - (35%)	Gaps:	71/341 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RVVVTGAAGQIAYS-LLYMIARGEVFGKDQPIVLHLLDIPPMVGVLEGVVMELADCALPLLVEVV 69
            ::.|.| .|::..: .|.:.|:|..   |:.::|.|.:     |. :|..|:|....|| .||:
Human   184 KITVVG-GGELGIACTLAISAKGIA---DRLVLLDLSE-----GT-KGATMDLEIFNLP-NVEI- 236

  Fly    70 PTTDPAVGFKDVSAA-------FLVGAMPRKEGMERKDLLSANVKIFRTQGQALDKFAKKDVKVL 127
                    .||:||:       |.|.::...:..  .|::.:||.:||....||..:::..| :|
Human   237 --------SKDLSASAHSKVVIFTVNSLGSSQSY--LDVVQSNVDMFRALVPALGHYSQHSV-LL 290

  Fly   128 VVGNPANTNALVCSSYAPSIPRENFSAMTRLDQNRATSQIAAKLGVPISAVKNIIIWGNHSSTQY 192
            |...|......|....:.............||..|....|...|....|. |.:.:.|
Human   291 VASQPVEIMTYVTWKLSTFPANRVIGIGCNLDSQRLQYIITNVLKAQTSG-KEVWVIG------- 347

  Fly   193 PDAGQAKVTANGTVKSVVDAINDNGYLQGSFVETVQKRGAAVIAAR-KMSSAMSAAKAACDHMHD 256
             :.|:.||......:.||           |....||....|:...| |...:.|...:..|.:..
Human   348 -EQGEDKVLTWSGQEEVV-----------SHTSQVQLSNRAMELLRVKGQRSWSVGLSVADMVDS 400

  Fly   257 WWNGTAPGQFVSMGVFSDGSYDSPKDVIFSFPVEIKNKQWKIVSGLTLSDFAKTKLSVTGKELQE 321
            ..|...  :..|:...:.|.||...:|..|.|.        |:....:|:..||.|
Human   401 IVNNKK--KVHSVSALAKGYYDINSEVFLSLPC--------ILGTNGVSEVIKTTL--------- 446

  Fly   322 EKDEALSVLDSNVSNL 337
            ::|.....|.|:.|::
Human   447 KEDTVTEKLQSSASSI 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdh1	NP_001285803.1	MDH_cytoplasmic_cytosolic	3..327	CDD:133421	70/329 (21%)
Mdh1	NP_001285803.1	MDH_euk_cyt	6..328	CDD:130819	70/330 (21%)
UEVLD	NP_001035787.1	UEV	21..138	CDD:283415
		PLN02602	161..471	CDD:178212	73/341 (21%)
		LDH_1	180..468	CDD:133429	73/341 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900