DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mdh1 and uevld

DIOPT Version :9

Sequence 1:	NP_001285803.1	Gene:	Mdh1 / 34414	FlyBaseID:	FBgn0262782	Length:	337	Species:	Drosophila melanogaster
Sequence 2:	NP_001003619.1	Gene:	uevld / 445225	ZFINID:	ZDB-GENE-040801-138	Length:	471	Species:	Danio rerio

Alignment Length:	303	Identity:	61/303 - (20%)
Similarity:	108/303 - (35%)	Gaps:	81/303 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EPIRVVVTGAAGQIAYSLLYMIARGEVFGKDQPIVLHLLDIPPMVGVLEGVVMELADCALPLLVE 67
            :.::|.|.|.......::|.::|:..|   |:   |.|:|||.  ...:|..|:|...:|| .||
Zfish   173 QEVKVSVIGGGDLGIAAVLSIMAKSCV---DK---LVLIDIPE--NSTKGGTMDLEIFSLP-KVE 228

  Fly    68 VVPTTDPAVGFKDVSAA-----FLVGAMPRKEGMERKDLLSANVKIFRTQGQALDKFAKKDVKVL 127
            |         .||:||:     .::.|....:......::..||.::|.....|.:.:...| ::
Zfish   229 V---------SKDLSASAGSKVLVITANAWSDEQSYLSVVQTNVDMYRGIIPRLAQLSPNAV-LV 283

  Fly   128 VVGNPANTNALVCSSYAPSIPRENFSAMTRLDQNRATSQIAAKLGVPISAVKN------------ 180
            :...|.:....|....:..:|.:.......||..| .|.|     :.||.|.|
Zfish   284 IASQPVDVMTHVAWRQSHLLPTQVIGVGCNLDSQR-LSHI-----INISLVANNTGKQAWVIGEL 342

  Fly   181 ----IIIWGNHSSTQYPDAGQAKVTANGTVKSVVDAINDNGYLQGSFVETVQKRG---------- 231
                :.:|||....  .|..||....:.:.|.::|..          .|.::.||
Zfish   343 SENKVAVWGNMGPG--TDQLQALTPVSNSTKPLMDRA----------FEMIKGRGQRSWSVGLSI 395

  Fly   232 -----AAVIAARKMSSAMSAAKAACDHMHDWWNGTAPGQFVSM 269
                 :.|...:|:.|..:.|:.        |.|.....|:|:
Zfish   396 ADITHSIVTNQKKVHSVTTLAEG--------WGGIGSKVFLSL 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdh1	NP_001285803.1	MDH_cytoplasmic_cytosolic	3..327	CDD:133421	61/303 (20%)
Mdh1	NP_001285803.1	MDH_euk_cyt	6..328	CDD:130819	61/300 (20%)
uevld	NP_001003619.1	UEV	21..139	CDD:283415
		LDH_1	172..468	CDD:133429	61/303 (20%)
		L-LDH-NAD	179..460	CDD:273796	60/297 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900