DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdh1 and MDH1

DIOPT Version :9

Sequence 1:	NP_001285803.1	Gene:	Mdh1 / 34414	FlyBaseID:	FBgn0262782	Length:	337	Species:	Drosophila melanogaster
Sequence 2:	NP_001303303.1	Gene:	MDH1 / 4190	HGNCID:	6970	Length:	353	Species:	Homo sapiens

Alignment Length:	333	Identity:	221/333 - (66%)
Similarity:	260/333 - (78%)	Gaps:	1/333 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAEPIRVVVTGAAGQIAYSLLYMIARGEVFGKDQPIVLHLLDIPPMVGVLEGVVMELADCALPLL 65
            |:|||||:||||||||||||||.|..|.||||||||:|.||||.||:|||:||:|||.|||||||
Human     1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLL 65

  Fly    66 VEVVPTTDPAVGFKDVSAAFLVGAMPRKEGMERKDLLSANVKIFRTQGQALDKFAKKDVKVLVVG 130
            .:|:.|....|.|||:..|.|||:|||:|||||||||.||||||::||.||||:|||.|||:|||
Human    66 KDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVG 130

  Fly   131 NPANTNALVCSSYAPSIPRENFSAMTRLDQNRATSQIAAKLGVPISAVKNIIIWGNHSSTQYPDA 195
            ||||||.|..|..|||||:||||.:||||.|||.:|||.||||..:.|||:|||||||||||||.
Human   131 NPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDV 195

  Fly   196 GQAKVTANGTVKSVVDAINDNGYLQGSFVETVQKRGAAVIAARKMSSAMSAAKAACDHMHDWWNG 260
            ..|||...|....|.:|:.|:.:|:|.||.|||:||||||.|||:|||||||||.|||:.|.|.|
Human   196 NHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFG 260

  Fly   261 TAPGQFVSMGVFSDG-SYDSPKDVIFSFPVEIKNKQWKIVSGLTLSDFAKTKLSVTGKELQEEKD 324
            |..|:||||||.||| ||..|.|:::||||.||||.||.|.||.::||::.|:.:|.|||.|||:
Human   261 TPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKE 325

  Fly   325 EALSVLDS 332
            .|...|.|
Human   326 SAFEFLSS 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdh1	NP_001285803.1	MDH_cytoplasmic_cytosolic	3..327	CDD:133421	217/324 (67%)
Mdh1	NP_001285803.1	MDH_euk_cyt	6..328	CDD:130819	215/322 (67%)
MDH1	NP_001303303.1	MalateDH-SF1	2..327	CDD:130820	217/324 (67%)
		MDH_cytoplasmic_cytosolic	3..328	CDD:133421	217/324 (67%)
		PTS1	351..353
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159247
Domainoid	1	1.000	215	1.000	Domainoid score	I2723
eggNOG	1	0.900	-	-		E1_COG0039
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4324
Inparanoid	1	1.050	438	1.000	Inparanoid score	I1695
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53893
OrthoDB	1	1.010	-	-		D1118998at2759
OrthoFinder	1	1.000	-	-		FOG0004059
OrthoInspector	1	1.000	-	-		oto91047
orthoMCL	1	0.900	-	-		OOG6_101066
Panther	1	1.100	-	-	LDO	PTHR23382
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4080
SonicParanoid	1	1.000	-	-		X2809
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800