Protein Alignment Mdh1 and LDHB

DIOPT Version :9

• Sequence 1: NP_001285803.1
• Gene: Mdh1 / 34414
• FlyBaseID: FBgn0262782
• Length: 337
• Species: Drosophila melanogaster
• Sequence 2: XP_006719137.1
• Gene: LDHB / 3945
• HGNCID: 6541
• Length: 353
• Species: Homo sapiens
• Alignment Length: 362
• Identity: 71/362 - (19%)
• Similarity: 128/362 - (35%)
• Gaps: 85/362 - (23%)

  Fly     6 RVVVTGAAGQIAYSLLYMIARGEVFGKDQPIVLHLLDIPPMVGVLEGVVMELADCALPLLVEVVP 70
            ::.|.| .||:.     |.....:.||.....|.|:|:  :...|:|.:|:|...:|.|
Human    23 KITVVG-VGQVG-----MACAISILGKSLADELALVDV--LEDKLKGEMMDLQHGSLFL------ 73

  Fly    71 TTDPAVGFKDVSA------AFLVGAMPRKEGMERKDLLSANVKIFRTQGQALDKFAKKDVKVLVV 129
            .|...|..||.|.      ..:...:.::||..|.:|:..||.:|:.....:.|:: .|..::||
Human    74 QTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIVKYS-PDCIIIVV 137

  Fly   130 GNPANTNALVCSSYAPSIPREN-FSAMTRLDQNRATSQIAAKLGVPISAVKNIIIWGNHSSTQY- 192
            .||.:....|....: .:|:.. ..:...||..|....:|.|||:..|:....|: |.|..:..
Human   138 SNPVDILTYVTWKLS-GLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWIL-GEHGDSSVA 200

  Fly   193 ----------------PDAGQAKVTANG------TVKSVVDAINDNGYLQ-------GSFVETVQ 228
                            |:.|....:.|.      .|:|..:.|...||..       ...:|::.
Human   201 VWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVESAYEVIKLKGYTNWAIGLSVADLIESML 265

  Fly   229 KR------GAAVIAARKMSSAMSAAKAACDHMHDWWNGTAPGQFVSMGVFSDGSYDSPKDVIFS- 286
            |.      .:.::..|:.::..:.......:.........|.:.:..|.|....:    .|.:|
Human   266 KNLSRIHPVSTMVKVRQTTTKCNMISRIVFYKKIHLKRLRPDKIIVQGYFCLSKF----YVNYSH 326

  Fly   287 FPVEIKNKQWKIVSGLTLSDFAKTKLSVTGKELQEEK 323
            ||.|:                    |...|::|:|.|
Human   327 FPTEV--------------------LDSKGRKLRESK 343

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdh1	NP_001285803.1	MDH_cytoplasmic_cytosolic	3..327	CDD:133421	71/362 (20%)
		MDH_euk_cyt	6..328	CDD:130819	71/362 (20%)
LDHB	XP_006719137.1	LDH_1	20..279	CDD:133429	57/272 (21%)
		L-LDH-NAD	26..279	CDD:273796	57/269 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810