Protein Alignment Mdh1 and LDHA

DIOPT Version :9

• Sequence 1: NP_001285803.1
• Gene: Mdh1 / 34414
• FlyBaseID: FBgn0262782
• Length: 337
• Species: Drosophila melanogaster
• Sequence 2: NP_001158886.1
• Gene: LDHA / 3939
• HGNCID: 6535
• Length: 361
• Species: Homo sapiens
• Alignment Length: 358
• Identity: 78/358 - (21%)
• Similarity: 122/358 - (34%)
• Gaps: 96/358 - (26%)

  Fly     5 IRVVVTGAAGQ-IAYSLLYMIARGEVFGKDQPIVLHLLDIPPMVGVLEGVVMELADCALPLLVEV 68
            |.||..||.|. .|.|:|.         ||....|.|:|:  :...|:|.:|:|...:|.|
Human    52 ITVVGVGAVGMACAISILM---------KDLADELALVDV--IEDKLKGEMMDLQHGSLFL---- 101

  Fly    69 VPTTDPAVGFKDVSA------AFLVGAMPRKEGMERKDLLSANVKIFRTQGQALDKFAKKDVKVL 127
              .|...|..||.:.      ..:.....::||..|.:|:..||.||:.....:.|:: .:.|:|
Human   102 --RTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYS-PNCKLL 163

  Fly   128 VVGNPANTNALVCSSYAPSIPRENFSAMTRLDQNRATSQIAAKLGV-PIS---------AVKNII 182
            :|.||.:....|....:.........:...||..|....:..:||| |:|         ...::.
Human   164 IVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVP 228

  Fly   183 IW------GNHSSTQYPDAG------QAKVTANGTVKSVVDAINDNGYLQ-------GSFVETVQ 228
            :|      |....|.:||.|      |.|......|:|..:.|...||..       ....|::.
Human   229 VWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIM 293

  Fly   229 KRGAAVIAARKMSSAMSAAKAACDHMHDWWNGTAPGQFVSMGVFSDGSYDSPKDVIFSFPVEIKN 293
            |.      .|::....:..|                          |.|....||..|.|.
Human   294 KN------LRRVHPVSTMIK--------------------------GLYGIKDDVFLSVPC---- 322

  Fly   294 KQWKIVSGLTLSDFAKTKLSVTGKELQEEKDEA 326
                |:....:||.  .|:::|.:|....|..|
Human   323 ----ILGQNGISDL--VKVTLTSEEEARLKKSA 349

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdh1	NP_001285803.1	MDH_cytoplasmic_cytosolic	3..327	CDD:133421	78/358 (22%)
		MDH_euk_cyt	6..328	CDD:130819	77/357 (22%)
LDHA	NP_001158886.1	LDH_1	48..358	CDD:133429	78/358 (22%)
		L-LDH-NAD	54..353	CDD:273796	77/356 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810