DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mdh1 and mdh1ab

DIOPT Version :9

Sequence 1:	NP_001285803.1	Gene:	Mdh1 / 34414	FlyBaseID:	FBgn0262782	Length:	337	Species:	Drosophila melanogaster
Sequence 2:	NP_001342472.1	Gene:	mdh1ab / 335715	ZFINID:	ZDB-GENE-030131-7655	Length:	354	Species:	Danio rerio

Alignment Length:	331	Identity:	220/331 - (66%)
Similarity:	266/331 - (80%)	Gaps:	1/331 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAEPIRVVVTGAAGQIAYSLLYMIARGEVFGKDQPIVLHLLDIPPMVGVLEGVVMELADCALPLL 65
            |:|||||:||||||||||||||.||:|:|||||||:||.||||.||:.|||||||||.|||||||
Zfish     1 MSEPIRVLVTGAAGQIAYSLLYGIAKGDVFGKDQPLVLLLLDITPMLPVLEGVVMELQDCALPLL 65

  Fly    66 VEVVPTTDPAVGFKDVSAAFLVGAMPRKEGMERKDLLSANVKIFRTQGQALDKFAKKDVKVLVVG 130
            .||:||....|.|||:.||.|||:|||:|||||||||.|||.||::||:||||:|||.|||||||
Zfish    66 REVIPTDKEDVAFKDLDAAILVGSMPRREGMERKDLLKANVAIFKSQGEALDKYAKKTVKVLVVG 130

  Fly   131 NPANTNALVCSSYAPSIPRENFSAMTRLDQNRATSQIAAKLGVPISAVKNIIIWGNHSSTQYPDA 195
            ||||||.|:.:..|||||:||||.:||||.|||:||:|.:.|:..:.|||:|||||||||||||.
Zfish   131 NPANTNCLIAAKSAPSIPKENFSCLTRLDHNRASSQVALRCGIAPNNVKNVIIWGNHSSTQYPDV 195

  Fly   196 GQAKVTANGTVKSVVDAINDNGYLQGSFVETVQKRGAAVIAARKMSSAMSAAKAACDHMHDWWNG 260
            ...||...|..::..||:.|:.:|:|.|:.|||:||||||.|||:|||||||||.||||.|.|.|
Zfish   196 HHCKVNVQGKDETAFDAVKDDAWLKGEFISTVQQRGAAVIKARKLSSAMSAAKAICDHMRDIWTG 260

  Fly   261 TAPGQFVSMGVFSDG-SYDSPKDVIFSFPVEIKNKQWKIVSGLTLSDFAKTKLSVTGKELQEEKD 324
            |..|:|:||||:|.| ||..|:|:|:|||:.||:|.||||.||.::||:|.|:..|..||.||:|
Zfish   261 TPEGEFISMGVYSTGNSYGVPEDLIYSFPISIKDKNWKIVDGLPINDFSKAKMEATAAELVEERD 325

  Fly   325 EALSVL 330
            .|||.|
Zfish   326 TALSFL 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdh1	NP_001285803.1	MDH_cytoplasmic_cytosolic	3..327	CDD:133421	215/324 (66%)
Mdh1	NP_001285803.1	MDH_euk_cyt	6..328	CDD:130819	213/322 (66%)
mdh1ab	NP_001342472.1	MDH_cytoplasmic_cytosolic	3..328	CDD:133421	215/324 (66%)
mdh1ab	NP_001342472.1	PTS1	352..354
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595366
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H4324
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1118998at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.940