DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mdh1 and Mdh1b

DIOPT Version :9

Sequence 1:	NP_001285803.1	Gene:	Mdh1 / 34414	FlyBaseID:	FBgn0262782	Length:	337	Species:	Drosophila melanogaster
Sequence 2:	XP_038939577.1	Gene:	Mdh1b / 316444	RGDID:	1307874	Length:	565	Species:	Rattus norvegicus

Alignment Length:	385	Identity:	105/385 - (27%)
Similarity:	170/385 - (44%)	Gaps:	64/385 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAEPIRVVVTGAAGQIAYSLLYMIARGEVFGKDQPIVLHLLDIPPMVGVLEGVVMELADCALPLL 65
            :..|::|.:|.|..::...|:.::..|||||....|.|.|.|.......|..:|||..:.|.|:|
  Rat   163 LISPLQVWITSAGSRVCCHLIPLLLSGEVFGMQAEISLTLFDQEQRRECLSNIVMETENLASPVL 227

  Fly    66 VEVVPTTDPAVGFKDVSAAFLVGAMPRKEGMERKDLLSANVKIFRTQGQALDKFAKKDVKVLVVG 130
            ..|...|.....|.......::.....:|....:..|.:.|.:.|..|..::|.|.|.|||:|.|
  Rat   228 RTVSFCTTVKDAFLQAEVIIILDDSTDEEVYNMESCLRSRVPLCRLYGYLIEKNAHKSVKVIVGG 292

  Fly   131 NP-ANTNALVCSSYAPSIPRENFSAMTRLDQNRATSQIAAKLGVPISAVKNIIIWGNHSSTQYPD 194
            .. .|....:...||||: ..|..|:....:.:|.:.:|.|:....|.:|::|||||.:...|.|
  Rat   293 KSFLNLKTTLLIQYAPSL-ASNIIAVALGLEGQAKAVLARKMKTIPSRIKDVIIWGNITGNNYVD 356

  Fly   195 AGQAKV--------TANGTVKSVVDAINDNGYLQGSFVETVQ------KRGAAVIAARKMSSAMS 245
            ..:|||        ...|...||:..|.|..::...||.|::      |:...::||..:::.:.
  Rat   357 LRKAKVYNYESAIRGPPGYYHSVLSLIFDREWITKEFVRTLKDLSSTGKQFGGILAAHSIATTLK 421

  Fly   246 AAKAACDHMHDWWNGTAPGQFVSMGVFSDGSYDSPKDVIFSFPVEIKNKQW-------------K 297
            .          |:.|:.||:.||:||.|:|.:..|:.::||.||:.:|..|             |
  Rat   422 Y----------WYYGSPPGEIVSLGVMSEGQFGIPEGIVFSMPVKFENGTWVVLTDLEDLSLSEK 476

  Fly   298 IVSGLTLSDFAKTKLSVTG------------KE-------LQEEKDEA-----LSVLDSN 333
            |::.|| .|..:.||..:|            |:       |.|||::|     |||.:.|
  Rat   477 IINRLT-GDLIQEKLVASGDLLTFQPIEEDPKDNTPSPTGLNEEKEQAESDSPLSVTEPN 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdh1	NP_001285803.1	MDH_cytoplasmic_cytosolic	3..327	CDD:133421	101/375 (27%)
Mdh1	NP_001285803.1	MDH_euk_cyt	6..328	CDD:130819	100/373 (27%)
Mdh1b	XP_038939577.1	NADB_Rossmann	44..494	CDD:419666	94/342 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353266
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740