DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdh1 and Ldhc

DIOPT Version :9

Sequence 1:	NP_001285803.1	Gene:	Mdh1 / 34414	FlyBaseID:	FBgn0262782	Length:	337	Species:	Drosophila melanogaster
Sequence 2:	XP_008757566.1	Gene:	Ldhc / 29634	RGDID:	69366	Length:	336	Species:	Rattus norvegicus

Alignment Length:	319	Identity:	68/319 - (21%)
Similarity:	109/319 - (34%)	Gaps:	83/319 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 VLEGVVMELA--DC--------ALPLLVEVVPTTDPAVGF-KDVSAA-----FLVGAMPRK-EGM 96
            :|:|:..|||  |.        ||.||...:..:.|.:.| ||.|.:     .::.|..|. .|.
  Rat    44 LLKGLADELALVDADENKLKGEALDLLHGSLFLSTPKIVFGKDYSVSANSKLVIITAGARMVSGE 108

  Fly    97 ERKDLLSANVKIFRTQGQALDKFAKKDVKVLVVGNPANTNALVCSSYAPSIPRENFSAMTRLDQN 161
            .|..||..||.|.:.....:.: ...|.|:::|.||.:....|....:.........:...||..
  Rat   109 SRLALLQRNVTIMKAIVPGVIQ-NSPDCKIMIVTNPVDILTYVVWKISGLPVSSVIGSGCNLDSA 172

  Fly   162 RATSQIAAKLGVPISAVKNIIIWGNHSSTQYP------DAGQAKVTANGTV-------------K 207
            |....|..||||..|:....:: |.|..:..|      .||....:.|..:             |
  Rat   173 RFRYLIGEKLGVNPSSCHGWVL-GEHGDSSVPIWSGVNIAGVTLKSLNPAIGSDSDKEQWKTVHK 236

  Fly   208 SVVD----AINDNGYLQGSFVETVQKRGAAVIAARKMSSAMSAAKAACDHMHDWWNGTAPGQFVS 268
            .|||    .:|..||...:...:|....|:::...|...|::
  Rat   237 QVVDGGYEVLNLKGYTSWAIALSVTDIAASILKNLKRVHAVT----------------------- 278

  Fly   269 MGVFSDGSYDSPKDVIFSFPVEIKNKQWKIVSGLTLSDFAKTKLSVTGKELQEEKDEAL 327
              ....|.|...:::..|.|..:..      ||:|  |..|..::.        ::|||
  Rat   279 --TLVKGLYGIKEEIFLSIPCVLGQ------SGIT--DLVKVNMNT--------EEEAL 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdh1	NP_001285803.1	MDH_cytoplasmic_cytosolic	3..327	CDD:133421	66/317 (21%)
Mdh1	NP_001285803.1	MDH_euk_cyt	6..328	CDD:130819	68/319 (21%)
Ldhc	XP_008757566.1	LDH_1	22..333	CDD:133429	68/319 (21%)
Ldhc	XP_008757566.1	L-LDH-NAD	29..329	CDD:273796	68/319 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900