DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mdh1 and mdh-1

DIOPT Version :9

Sequence 1:	NP_001285803.1	Gene:	Mdh1 / 34414	FlyBaseID:	FBgn0262782	Length:	337	Species:	Drosophila melanogaster
Sequence 2:	NP_504656.1	Gene:	mdh-1 / 179041	WormBaseID:	WBGene00018491	Length:	336	Species:	Caenorhabditis elegans

Alignment Length:	332	Identity:	203/332 - (61%)
Similarity:	244/332 - (73%)	Gaps:	1/332 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAEPIRVVVTGAAGQIAYSLLYMIARGEVFGKDQPIVLHLLDIPPMVGVLEGVVMELADCALPLL 65
            |:.|:||:||||||||.||::..||.|.||||:||:.|.|||:|....:|||||.||.|||||.|
Worm     1 MSAPLRVLVTGAAGQIGYSIVIRIADGTVFGKEQPVELVLLDVPQCSNILEGVVFELQDCALPTL 65

  Fly    66 VEVVPTTDPAVGFKDVSAAFLVGAMPRKEGMERKDLLSANVKIFRTQGQALDKFAKKDVKVLVVG 130
            ..||..||....|..:..|||||||||:|||||||||:||||||::||:||.::||...||:|||
Worm    66 FSVVAVTDEKSAFTGIDYAFLVGAMPRREGMERKDLLAANVKIFKSQGKALAEYAKPTTKVIVVG 130

  Fly   131 NPANTNALVCSSYAP-SIPRENFSAMTRLDQNRATSQIAAKLGVPISAVKNIIIWGNHSSTQYPD 194
            |||||||.:.:.||. .||.:|||||||||.|||.:|:|.|.|..|..|||:|||||||.||:||
Worm   131 NPANTNAFIAAKYAAGKIPAKNFSAMTRLDHNRALAQLALKTGTTIGNVKNVIIWGNHSGTQFPD 195

  Fly   195 AGQAKVTANGTVKSVVDAINDNGYLQGSFVETVQKRGAAVIAARKMSSAMSAAKAACDHMHDWWN 259
            ...|.|..|||......|:.||.:|||.|:.||||||..:|..||:|||||||||||||:|||..
Worm   196 VTHATVNKNGTETDAYAAVGDNAFLQGPFIATVQKRGGVIIEKRKLSSAMSAAKAACDHIHDWHF 260

  Fly   260 GTAPGQFVSMGVFSDGSYDSPKDVIFSFPVEIKNKQWKIVSGLTLSDFAKTKLSVTGKELQEEKD 324
            ||..||||||.|.|||||..|:.:||||||.|:..:||||.||:..||||.|::.|.|||:||:|
Worm   261 GTKAGQFVSMAVPSDGSYGIPQGLIFSFPVTIEGGEWKIVQGLSFDDFAKGKIAATTKELEEERD 325

  Fly   325 EALSVLD 331
            :||...|
Worm   326 DALKACD 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdh1	NP_001285803.1	MDH_cytoplasmic_cytosolic	3..327	CDD:133421	199/324 (61%)
Mdh1	NP_001285803.1	MDH_euk_cyt	6..328	CDD:130819	199/322 (62%)
mdh-1	NP_504656.1	PRK05442	1..325	CDD:235468	199/323 (62%)
mdh-1	NP_504656.1	MDH_cytoplasmic_cytosolic	3..328	CDD:133421	199/324 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166823
Domainoid	1	1.000	217	1.000	Domainoid score	I1548
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4324
Inparanoid	1	1.050	404	1.000	Inparanoid score	I1081
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53893
OrthoDB	1	1.010	-	-		D1118998at2759
OrthoFinder	1	1.000	-	-		FOG0004059
OrthoInspector	1	1.000	-	-		oto19395
orthoMCL	1	0.900	-	-		OOG6_101066
Panther	1	1.100	-	-	LDO	PTHR23382
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4080
SonicParanoid	1	1.000	-	-		X2809
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.940