Protein Alignment Mdh1 and Ldhb

DIOPT Version :10

• Sequence 1: NP_609394.1
• Gene: Mdh1 / 34414
• FlyBaseID: FBgn0262782
• Length: 337
• Species: Drosophila melanogaster
• Sequence 2: NP_001303251.1
• Gene: Ldhb / 16832
• MGIID: 96763
• Length: 341
• Species: Mus musculus
• Alignment Length: 367
• Identity: 73/367 - (19%)
• Similarity: 127/367 - (34%)
• Gaps: 100/367 - (27%)

  Fly     6 RVVVTGAAGQIAYSLLYMIARGEVFGKDQPIVLHLLDIPPMVGVLEGVVMELADCALPLLVEVVP 70
            ::.|.| .||:.     |.....:.||.....|.|:|:  :...|:|.:|:|...:|.|
Mouse    23 KITVVG-VGQVG-----MACAISILGKSLADELALVDV--LEDKLKGEMMDLQHGSLFL------ 73

  Fly    71 TTDPAVGFKDVSA------AFLVGAMPRKEGMERKDLLSANVKIFRTQGQALDKFAKKDVKVLVV 129
            .|...|..||.|.      ..:...:.::||..|.:|:..||.:|:.....:.|:: .|..::||
Mouse    74 QTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIVKYS-PDCTIIVV 137

  Fly   130 GNPANTNALVCSSYAPSIPREN-FSAMTRLDQNRATSQIAAKLGVPISAVKNIIIWGNHSSTQY- 192
            .||.:....|....: .:|:.. ..:...||..|....:|.|||:..|:....|: |.|..:..
Mouse   138 SNPVDILTYVTWKLS-GLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWIL-GEHGDSSVA 200

  Fly   193 ----------------PDAGQAKVTANGTVKSVVDAINDNGYLQGSFVETVQKRGAAVIAARKMS 241
                            |:.|....:.|.  |.|...:.|:.|      |.::.:|..
Mouse   201 VWSGVNVAGVSLQELNPEMGTDNDSENW--KEVHKMVVDSAY------EVIKLKGYT-------- 249

  Fly   242 SAMSAAKAACDHMHDWWNGTAPGQFVS-----------MGVFSDGSYDSPKDVIFSFPVEIKNKQ 295
                          :|..|.:....:.           :.....|.|....:|..|.|..:..:
Mouse   250 --------------NWAIGLSVADLIESMLKNLSRIHPVSTMVKGMYGIENEVFLSLPCILNAR- 299

  Fly   296 WKIVSGLTLSDFAKTKLSVTGKELQEEKDEALSVLDSNVSNL 337
                 |||         ||..::|   ||:.::.|..:...|
Mouse   300 -----GLT---------SVINQKL---KDDEVAQLRKSADTL 324

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdh1	NP_609394.1	MDH_cytoplasmic_cytosolic	3..327	CDD:133421	71/355 (20%)
Ldhb	NP_001303251.1	LDH_1	20..330	CDD:133429	73/367 (20%)
		PTS1	339..341