Protein Alignment Mdh1 and MDH1B

DIOPT Version :9

• Sequence 1: NP_001285803.1
• Gene: Mdh1 / 34414
• FlyBaseID: FBgn0262782
• Length: 337
• Species: Drosophila melanogaster
• Sequence 2: NP_001034934.1
• Gene: MDH1B / 130752
• HGNCID: 17836
• Length: 518
• Species: Homo sapiens
• Alignment Length: 366
• Identity: 95/366 - (25%)
• Similarity: 166/366 - (45%)
• Gaps: 52/366 - (14%)

  Fly     4 PIRVVVTGAAGQIAYSLLYMIARGEVFGKDQPIVLHLLDIPPMVGVLEGVVMELADCALPLLVEV 68
            |::|.:|.|:....|:|:.::..|||||....|.:.|.|.......|:.:|:|..|.|.|:|..|
Human   131 PLQVWITSASAPACYNLIPILTSGEVFGMHTEISITLFDNKQAEEHLKSLVVETQDLASPVLRSV 195

  Fly    69 VPTTDPAVGFKDVSAAFLVGAMPRKEGMERKDLLSANVKIFRTQGQALDKFAKKDVKVLVVGNP- 132
            ...|.....|:......::.....||....:|.|.:.|.:.|..|..::|.|.:.|:|:|.|..
Human   196 SICTKVEEAFRQAHVIVVLDDSTNKEVFTLEDCLRSRVPLCRLYGYLIEKNAHESVRVIVGGRTF 260

  Fly   133 ANTNALVCSSYAPSIPRENFSAMTRLDQNRATSQIAAKLGVPISAVKNIIIWGNHSSTQYPDAGQ 197
            .|...::...|||.| ..|..|:....:..|.:.:|.||....|.:|::|||||.|...|.|..:
Human   261 VNLKTVLLMRYAPRI-AHNIIAVALGVEGEAKAILARKLKTAPSYIKDVIIWGNISGNNYVDLRK 324

  Fly   198 AKVTANGTV--------KSVVDAINDNGYLQGSFV------ETVQKRGAAVIAARKMSSAMSAAK 248
            .:|....:.        :.|::.|.|:.:::..||      .|..::...::||..:::.:..
Human   325 TRVYRYESAIWGPLHYSRPVLNLIFDSEWVKREFVAILKNLTTTGRQFGGILAAHSIATTLKY-- 387

  Fly   249 AACDHMHDWWNGTAPGQFVSMGVFSDGSYDSPKDVIFSFPVEIKNKQWKIVSGL----------- 302
                    |::|:.||:.||:|:.|:|.:..||.::||.||:.:|..|.:::.|
Human   388 --------WYHGSPPGEIVSLGILSEGQFGIPKGIVFSMPVKFENGTWVVLTDLKDVEISEQIMT 444

  Fly   303 -TLSDFAKTKLSVTGKEL--------------QEEKDEALS 328
             ..||..:.||...|.::              .|||:.|:|
Human   445 RMTSDLIQEKLVALGDKIHFQPYQSGHKDLVPDEEKNLAMS 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdh1	NP_001285803.1	MDH_cytoplasmic_cytosolic	3..327	CDD:133421	93/363 (26%)
		MDH_euk_cyt	6..328	CDD:130819	93/362 (26%)
MDH1B	NP_001034934.1	MDH_like	9..459	CDD:133431	89/338 (26%)
		MalateDH-SF1	131..457	CDD:130820	89/336 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159246
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740