Protein Alignment da and Tcf4

DIOPT Version :9

• Sequence 1: NP_001356956.1
• Gene: da / 34413
• FlyBaseID: FBgn0267821
• Length: 775
• Species: Drosophila melanogaster
• Sequence 2: XP_038953085.1
• Gene: Tcf4 / 84382
• RGDID: 69271
• Length: 669
• Species: Rattus norvegicus
• Alignment Length: 735
• Identity: 213/735 - (28%)
• Similarity: 290/735 - (39%)
• Gaps: 221/735 - (30%)

  Fly    22 IANKQPTGTVGADRG-----GGGGYHSP---YG-----------SLGVENGMYPSDFNS--MHDT 65
            :|:...||:...||.     |.||:.||   ||           .||..:.:.|...||  ...|
  Rat    40 LASGHFTGSNVEDRSSSGSWGNGGHPSPSRNYGDGTPYDHMTSRDLGSHDNLSPPFVNSRIQSKT 104

  Fly    66 VNGGNNRYANASTVDQYFDSAAAG----SGGAWCQPQMSSANSYMGQSAYQNSGPLSGHSIDQQQ 126
            ..|..:.|...:....:..|...|    .......|....:..|...|......||...:::.|.
  Rat   105 ERGSYSSYGRENVQGCHQQSLLGGDMDMGNPGTLSPTKPGSQYYPYSSNNARRRPLHSSTMEVQT 169

  Fly   127 QQVHQADGLGMGGGGGGGVGADGMHCPVTTGLPPISSFRPTSG----GIGGPGAGQQAPVNVNVN 187
            ::|.:                      |..|||. |.:.|::.    ....||.....|.
  Rat   170 KKVRK----------------------VPPGLPS-SVYAPSASTADYNRDSPGYSSSKPA----- 206

  Fly   188 PPAVFNSP---QAHNHNHTVQAQHSALSTAGPLGHHSLNHTPHAHSHTLPLPHALPHGHTLPHPH 249
             .:.|:|.   |..:|:....:..|.::..|..|....:|.|.:.|:....||     ..|.:|.
  Rat   207 -ASTFSSSFFMQDGHHSSDPWSSSSGMNQPGYGGMLGNSHIPQSSSYCSLHPH-----ERLSYPS 265

  Fly   250 HSQQN------------------------SPAVQSSDAF-----SGAGASVKVAGAGNSSAAALR 285
            ||..:                        :|....:|:.     :||..|.:...|...:.|::
  Rat   266 HSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGTGAAGSSQTGDALGKALASI- 329

  Fly   286 QQMYMPADQSISSFGSNPSTPVNSPPPLTQSVVGGGGEPSVSGGSGWGHSVLNGGPSSSYASEMV 350
               |.| |.:.:||.|||||||.|||.|:            :|.:.|..   |||.:||..:...
  Rat   330 ---YSP-DHTNNSFSSNPSTPVGSPPSLS------------AGTAVWSR---NGGQASSSPNYEG 375

  Fly   351 PVSSLHTMASVFQGVRME---ERLDDALNVLRNHCEPEMLAGVNQSLASIDNIDALTSFVPN--- 409
            |:.||.:        |:|   ||||||::|||||       .|..|.|           ||.
  Rat   376 PLHSLQS--------RIEDRLERLDDAIHVLRNH-------AVGPSTA-----------VPGGHG 414

  Fly   410 ------SPSHLGSGGNSGSVSNTSNAALVHEVLALGAAAAAGTSGQSVGGAGSLASLKLDRSAST 468
                  .|||.|:.|:.||...|...:.....|.:||....|.:
  Rat   415 DMHGIIGPSHNGAMGSLGSGYGTGLLSANRHSLMVGAHREDGVA--------------------- 458

  Fly   469 SLPKQTKKRKEHTAISNSVPAGVSTTSSLTSLDISDTKPT----------SSIESSNSGLQQHSQ 523
                   .|..|:.:.|.||.......|.||.|::..:..          .|:.|.:|.::...:
  Rat   459 -------LRGSHSLLPNQVPVPQLPVQSATSPDLNPPQDPYRGMPPGLQGQSVSSGSSEIKSDDE 516

  Fly   524 G-------------------KGTKRPRRYCSSADEDDDAEPAVKAIREKERRQANNARERIRIRD 569
            |                   |..|...|..||.::|:|..|..||.||||||.|||||||:|:||
  Rat   517 GDENLQDTKSSEDKKLDDDKKDIKSITRSRSSNNDDEDLTPEQKAEREKERRMANNARERLRVRD 581

  Fly   570 INEALKELGRMCMTHLKSDKPQTKLGILNMAVEVIMTLEQQVRERNLNPKAACLKRREEEK-AED 633
            ||||.||||||...|||||||||||.||:.||.||::|||||||||||||||||||||||| :.:
  Rat   582 INEAFKELGRMVQLHLKSDKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSSE 646

  Fly   634 GPKLS----------AQHHM 643
            .|.||          |.:||
  Rat   647 PPPLSLAGPHPGMGDAANHM 666

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
da	NP_001356956.1	HLH	560..613	CDD:197674	40/52 (77%)
Tcf4	XP_038953085.1	ROM1	135..>296	CDD:227709	32/194 (16%)
		bHLH_E-protein_TCF4_E2-2	560..644	CDD:381515	69/83 (83%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343665
Domainoid	1	1.000	86	1.000	Domainoid score	I7894
eggNOG	1	0.900	-	-		E1_KOG3910
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	210	1.000	Inparanoid score	I3581
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D260626at33208
OrthoFinder	1	1.000	-	-		FOG0001459
OrthoInspector	1	1.000	-	-		otm44834
orthoMCL	1	0.900	-	-		OOG6_105744
Panther	1	1.100	-	-	O	PTHR11793
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1175
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.760