DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment da and TCF4

DIOPT Version :9

Sequence 1:	NP_001356956.1	Gene:	da / 34413	FlyBaseID:	FBgn0267821	Length:	775	Species:	Drosophila melanogaster
Sequence 2:	NP_001230155.2	Gene:	TCF4 / 6925	HGNCID:	11634	Length:	773	Species:	Homo sapiens

Alignment Length:	728	Identity:	217/728 - (29%)
Similarity:	291/728 - (39%)	Gaps:	205/728 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 IANKQPTGTVGADRG-----GGGGYHSP---YG-----------SLGVENGMYPSDFNS--MHDT 65
            :|:...||:...||.     |.||:.||   ||           .||..:.:.|...||  ...|
Human   142 LASGHFTGSNVEDRSSSGSWGNGGHPSPSRNYGDGTPYDHMTSRDLGSHDNLSPPFVNSRIQSKT 206

  Fly    66 VNGGNNRYANASTVDQYFDSAAAGSGGAWCQPQMSSANSYMGQSAYQNSG------PLSGHSIDQ 124
            ..|..:.|...|.:......:..|.......|...|... .|...||.|.      ||...:::.
Human   207 ERGSYSSYGRESNLQGCHQQSLLGGDMDMGNPGTLSPTK-PGSQYYQYSSNNPRRRPLHSSAMEV 270

  Fly   125 QQQQVHQADGLGMGGGGGGGVGADGMHCPVTTGLPPISSFRPTSG----GIGGPGAGQQAPVNVN 185
            |.::|.:                      |..|||. |.:.|::.    ....||.....|....
Human   271 QTKKVRK----------------------VPPGLPS-SVYAPSASTADYNRDSPGYPSSKPATST 312

  Fly   186 VNPPAVFNSPQAHNHNHTVQAQHSALST---AGPLGHHSLNHTPHAHSHTLPLPHALPHGHTLPH 247
            .  |:.|.....| |:....:..|.::.   ||.||:.|  |.|.:.|:....||     ..|.:
Human   313 F--PSSFFMQDGH-HSSDPWSSSSGMNQPGYAGMLGNSS--HIPQSSSYCSLHPH-----ERLSY 367

  Fly   248 PHHSQQN------------------------SPAVQSSDAF-----SGAGASVKVAGAGNSSAAA 283
            |.||..:                        :|....:|:.     |||..|.:...|...:.|:
Human   368 PSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGSGAAGSSQTGDALGKALAS 432

  Fly   284 LRQQMYMPADQSISSFGSNPSTPVNSPPPLTQSVVGGGGEPSVSGGSGWGHSVLNGGPSSSYASE 348
            :    |.| |.:.:||.|||||||.|||.|:            :|.:.|..   |||.:||..:.
Human   433 I----YSP-DHTNNSFSSNPSTPVGSPPSLS------------AGTAVWSR---NGGQASSSPNY 477

  Fly   349 MVPVSSLHTMASVFQGVRME---ERLDDALNVLRNHCEPEMLAGVNQSLASIDNIDALTSFVPNS 410
            ..|:.||.:        |:|   ||||||::|||||       .|..|.|.......:...:  .
Human   478 EGPLHSLQS--------RIEDRLERLDDAIHVLRNH-------AVGPSTAMPGGHGDMHGII--G 525

  Fly   411 PSHLGSGGNSGSVSNTSNAALVHEVLALGAAAAAGTSGQSVGGAGSLASLKLDRSASTSLPKQTK 475
            |||.|:.|..||...|...:.....|.:|.....|.:
Human   526 PSHNGAMGGLGSGYGTGLLSANRHSLMVGTHREDGVA---------------------------- 562

  Fly   476 KRKEHTAISNSVPAGVSTTSSLTSLDISDTKPT----------SSIESSNSGLQQHSQG------ 524
            .|..|:.:.|.||.......|.||.|::..:..          .|:.|.:|.::...:|
Human   563 LRGSHSLLPNQVPVPQLPVQSATSPDLNPPQDPYRGMPPGLQGQSVSSGSSEIKSDDEGDENLQD 627

  Fly   525 -------------KGTKRPRRYCSSADEDDDAEPAVKAIREKERRQANNARERIRIRDINEALKE 576
                         |..|...|..||.::|:|..|..||.||||||.|||||||:|:||||||.||
Human   628 TKSSEDKKLDDDKKDIKSITRSRSSNNDDEDLTPEQKAEREKERRMANNARERLRVRDINEAFKE 692

  Fly   577 LGRMCMTHLKSDKPQTKLGILNMAVEVIMTLEQQVRERNLNPKAACLKRREEEK-AEDGPKLS-- 638
            ||||...|||||||||||.||:.||.||::|||||||||||||||||||||||| :.:.|.||
Human   693 LGRMVQLHLKSDKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSSEPPPLSLA 757

  Fly   639 --------AQHHM 643
                    |.:||
Human   758 GPHPGMGDASNHM 770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
da	NP_001356956.1	HLH	560..613	CDD:197674	40/52 (77%)
TCF4	NP_001230155.2	HLH	676..729	CDD:197674	40/52 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149770
Domainoid	1	1.000	86	1.000	Domainoid score	I8084
eggNOG	1	0.900	-	-		E1_KOG3910
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	210	1.000	Inparanoid score	I3669
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D260626at33208
OrthoFinder	1	1.000	-	-		FOG0001459
OrthoInspector	1	1.000	-	-		otm40698
orthoMCL	1	0.900	-	-		OOG6_105744
Panther	1	1.100	-	-	O	PTHR11793
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4532
SonicParanoid	1	1.000	-	-		X1175
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790