Protein Alignment da and TCF4

DIOPT Version :10

• Sequence 1: NP_001356956.1
• Gene: da / 34413
• FlyBaseID: FBgn0267821
• Length: 775
• Species: Drosophila melanogaster
• Sequence 2: NP_001230155.2
• Gene: TCF4 / 6925
• HGNCID: 11634
• Length: 773
• Species: Homo sapiens
• Alignment Length: 728
• Identity: 217/728 - (29%)
• Similarity: 291/728 - (39%)
• Gaps: 205/728 - (28%)

  Fly    22 IANKQPTGTVGADRG-----GGGGYHSP---YG-----------SLGVENGMYPSDFNS--MHDT 65
            :|:...||:...||.     |.||:.||   ||           .||..:.:.|...||  ...|
Human   142 LASGHFTGSNVEDRSSSGSWGNGGHPSPSRNYGDGTPYDHMTSRDLGSHDNLSPPFVNSRIQSKT 206

  Fly    66 VNGGNNRYANASTVDQYFDSAAAGSGGAWCQPQMSSANSYMGQSAYQNSG------PLSGHSIDQ 124
            ..|..:.|...|.:......:..|.......|...|... .|...||.|.      ||...:::.
Human   207 ERGSYSSYGRESNLQGCHQQSLLGGDMDMGNPGTLSPTK-PGSQYYQYSSNNPRRRPLHSSAMEV 270

  Fly   125 QQQQVHQADGLGMGGGGGGGVGADGMHCPVTTGLPPISSFRPTSG----GIGGPGAGQQAPVNVN 185
            |.::|.:                      |..|||. |.:.|::.    ....||.....|....
Human   271 QTKKVRK----------------------VPPGLPS-SVYAPSASTADYNRDSPGYPSSKPATST 312

  Fly   186 VNPPAVFNSPQAHNHNHTVQAQHSALST---AGPLGHHSLNHTPHAHSHTLPLPHALPHGHTLPH 247
            .  |:.|.....| |:....:..|.::.   ||.||:.|  |.|.:.|:....||     ..|.:
Human   313 F--PSSFFMQDGH-HSSDPWSSSSGMNQPGYAGMLGNSS--HIPQSSSYCSLHPH-----ERLSY 367

  Fly   248 PHHSQQN------------------------SPAVQSSDAF-----SGAGASVKVAGAGNSSAAA 283
            |.||..:                        :|....:|:.     |||..|.:...|...:.|:
Human   368 PSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGSGAAGSSQTGDALGKALAS 432

  Fly   284 LRQQMYMPADQSISSFGSNPSTPVNSPPPLTQSVVGGGGEPSVSGGSGWGHSVLNGGPSSSYASE 348
            :    |.| |.:.:||.|||||||.|||.|:            :|.:.|..   |||.:||..:.
Human   433 I----YSP-DHTNNSFSSNPSTPVGSPPSLS------------AGTAVWSR---NGGQASSSPNY 477

  Fly   349 MVPVSSLHTMASVFQGVRME---ERLDDALNVLRNHCEPEMLAGVNQSLASIDNIDALTSFVPNS 410
            ..|:.||.:        |:|   ||||||::|||||       .|..|.|.......:...:  .
Human   478 EGPLHSLQS--------RIEDRLERLDDAIHVLRNH-------AVGPSTAMPGGHGDMHGII--G 525

  Fly   411 PSHLGSGGNSGSVSNTSNAALVHEVLALGAAAAAGTSGQSVGGAGSLASLKLDRSASTSLPKQTK 475
            |||.|:.|..||...|...:.....|.:|.....|.:
Human   526 PSHNGAMGGLGSGYGTGLLSANRHSLMVGTHREDGVA---------------------------- 562

  Fly   476 KRKEHTAISNSVPAGVSTTSSLTSLDISDTKPT----------SSIESSNSGLQQHSQG------ 524
            .|..|:.:.|.||.......|.||.|::..:..          .|:.|.:|.::...:|
Human   563 LRGSHSLLPNQVPVPQLPVQSATSPDLNPPQDPYRGMPPGLQGQSVSSGSSEIKSDDEGDENLQD 627

  Fly   525 -------------KGTKRPRRYCSSADEDDDAEPAVKAIREKERRQANNARERIRIRDINEALKE 576
                         |..|...|..||.::|:|..|..||.||||||.|||||||:|:||||||.||
Human   628 TKSSEDKKLDDDKKDIKSITRSRSSNNDDEDLTPEQKAEREKERRMANNARERLRVRDINEAFKE 692

  Fly   577 LGRMCMTHLKSDKPQTKLGILNMAVEVIMTLEQQVRERNLNPKAACLKRREEEK-AEDGPKLS-- 638
            ||||...|||||||||||.||:.||.||::|||||||||||||||||||||||| :.:.|.||
Human   693 LGRMVQLHLKSDKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSSEPPPLSLA 757

  Fly   639 --------AQHHM 643
                    |.:||
Human   758 GPHPGMGDASNHM 770

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
da	NP_001356956.1	bHLH_E-protein_Da_like	554..623	CDD:381473	55/68 (81%)
TCF4	NP_001230155.2	bHLH_E-protein_TCF4_E2-2	664..748	CDD:381515	69/83 (83%)