Protein Alignment da and tcf3b

DIOPT Version :9

• Sequence 1: NP_001356956.1
• Gene: da / 34413
• FlyBaseID: FBgn0267821
• Length: 775
• Species: Drosophila melanogaster
• Sequence 2: NP_001166154.1
• Gene: tcf3b / 664768
• ZFINID: ZDB-GENE-051113-64
• Length: 652
• Species: Danio rerio
• Alignment Length: 690
• Identity: 201/690 - (29%)
• Similarity: 284/690 - (41%)
• Gaps: 218/690 - (31%)

  Fly    28 TGTVGADRGGGGGYHSPYGSLGVENGMYPSDF-----NSMHDT-VNGGNNRYANASTVDQYFDSA 86
            ||..|.:..|      ||.|.|.:.|..|||.     ::|..: :..|:          |::.|.
Zfish    91 TGISGKNERG------PYSSFGGQPGFLPSDIAIPSADAMSPSGLKSGS----------QFYPSY 139

  Fly    87 A------AGSGGAWCQPQ---------------MSSANSYMGQS-AYQNSGPLSGHSIDQQQQQV 129
            |      ...||...|||               .:|.:.|:..| ||..|.|.|.:.
Zfish   140 ANNPRRRPSDGGMDPQPQKKIRKPPGLPSSVYAATSGDDYIRDSAAYPGSKPGSVYP-------- 196

  Fly   130 HQADGLGMGGGGGGGVGADGMHCPVTTGLPPISSFRP--TSGGIGGPGAGQQAPVNVNVNPPAVF 192
                        |.....:|:|          ||..|  .||.:|..|.......:.::|.||.|
Zfish   197 ------------GSFYMQEGLH----------SSSDPWAPSGSLGQSGYTAMLANSPHINQPASF 239

  Fly   193 N--SPQAHN----HNHTVQAQHSALSTAGPLGHHSLNHTPHAHSHTLPLPHALPHGHTLPHPHHS 251
            :  :||...    |...|...||..:               |:|||
Zfish   240 SAINPQDRMNYPLHGADVNGFHSGSA---------------AYSHT------------------- 270

  Fly   252 QQNSPAVQSSDAFSGAGASVKVAGAGNSSAAALRQQMYMPADQSISSFGSNPSTPVNSPPPLTQS 316
                .::..||:...:..:| .:.:|:....|| ..:| |:|.:.::|.|.|||||.||..:
Zfish   271 ----SSINGSDSILASRGTV-ASSSGDEIGKAL-ASIY-PSDHNSNNFSSTPSTPVGSPQGI--- 325

  Fly   317 VVGGGGEPSVSGGSGWGHSVLNGGPSSSYASEMVPVSSLHTMASVFQGVRMEERLDDALNVLRNH 381
                     .:|.:.|..:......|.:|.      ..||.:.:     :||:||::|::|||:|
Zfish   326 ---------ATGATQWSRASGQAALSPNYE------GGLHALQN-----KMEDRLEEAIHVLRSH 370

  Fly   382 CEPE-------------MLAGVNQSLASIDNIDALTS--FVPNSPSHLGSGGNSGSVSNTSNAAL 431
            ...:             :|:.|:.|.||:.:|....|  .:|.|..|....|:    .:..:|.|
Zfish   371 AVGQAPGIPGAHADMHGLLSAVSTSSASMGSIPQAYSNAGLPLSNRHPAMAGS----HHDDHACL 431

  Fly   432 VHEVLALGAAAAAGTSGQSVGGAGSLASLKLDRSASTSLPKQTKKRKEHTAISNSVPAGVSTTSS 496
            ......|.:|.|:||  ...|||        ..:.:||                .:|.|::..:.
Zfish   432 PPSSTLLQSAHASGT--PQPGGA--------PEAFNTS----------------GLPGGLAHATH 470

  Fly   497 LTSLDISDTKPTSSIESSNSGL-----QQHSQGKGTKRPRRYCSS------------ADEDDDAE 544
              |.:.||.|.....:..||.:     ::..:.|...|||:...|            .:||||.|
Zfish   471 --SSNKSDIKREEKEDDENSSVADKSEEEKKESKPRTRPRKEVFSQVLSGVSDQGEDLNEDDDDE 533

  Fly   545 --PA-VKAIREKERRQANNARERIRIRDINEALKELGRMCMTHLKSDKPQTKLGILNMAVEVIMT 606
              || ||..||||||.|||||||:|:||||||.|||||||..||.:|||||||.||:.||.||:.
Zfish   534 DLPAEVKVEREKERRVANNARERLRVRDINEAFKELGRMCQLHLSNDKPQTKLLILHQAVNVILN 598

  Fly   607 LEQQVRERNLNPKAACLKRREEEK-----AEDGPKLSAQH 641
            ||||||||||||||||||||||||     .:...:||..|
Zfish   599 LEQQVRERNLNPKAACLKRREEEKVSGVVGDTQMQLSGPH 638

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
da	NP_001356956.1	HLH	560..613	CDD:197674	39/52 (75%)
tcf3b	NP_001166154.1	HLH	552..605	CDD:197674	39/52 (75%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583914
Domainoid	1	1.000	85	1.000	Domainoid score	I8119
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	207	1.000	Inparanoid score	I3676
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D260626at33208
OrthoFinder	1	1.000	-	-		FOG0001459
OrthoInspector	1	1.000	-	-		otm24503
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11793
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4532
SonicParanoid	1	1.000	-	-		X1175
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	11.120