DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment da and ASCL1

DIOPT Version :9

Sequence 1:	NP_001356956.1	Gene:	da / 34413	FlyBaseID:	FBgn0267821	Length:	775	Species:	Drosophila melanogaster
Sequence 2:	NP_004307.2	Gene:	ASCL1 / 429	HGNCID:	738	Length:	236	Species:	Homo sapiens

Alignment Length:	275	Identity:	58/275 - (21%)
Similarity:	86/275 - (31%)	Gaps:	95/275 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   429 AALVHEVLALGAAAAAGTSGQSV------------------------GGAGSLASLKLDRSASTS 469
            ||......|..|||||..:.||.                        .|.|           ..|
Human    28 AACFFATAAAAAAAAAAAAAQSAQQQQQQQQQQQQAPQLRPAADGQPSGGG-----------HKS 81

  Fly   470 LPKQTKKRKEHTAISNSVPAGVSTTSSLTSLDISDTKPTSSIESSNSGLQQHSQGKGTKRPRRYC 534
            .|||.|:::                             :||.|......:.:..|.|...|::
Human    82 APKQVKRQR-----------------------------SSSPELMRCKRRLNFSGFGYSLPQQ-- 115

  Fly   535 SSADEDDDAEPAVKAIREKERRQANNARERIRIRDINEALKELGRMCMTHLKSDKPQTKLGILNM 599
                     :||..|.|        |.|||.|::.:|.....| |..:.:..::|..:|:..|..
Human   116 ---------QPAAVARR--------NERERNRVKLVNLGFATL-REHVPNGAANKKMSKVETLRS 162

  Fly   600 AVEVIMTLEQQVRERNLNPKAACLKRREEEKAEDGPKLSAQHHMIPQPQQVGGTPGSSYHSQPAQ 664
            |||.|..|:|.:.|.:....|.       :.....|.:|..:.  .....:.|:|.|||.|....
Human   163 AVEYIRALQQLLDEHDAVSAAF-------QAGVLSPTISPNYS--NDLNSMAGSPVSSYSSDEGS 218

  Fly   665 LVP--PSSQTISTMT 677
            ..|  |..|.:...|
Human   219 YDPLSPEEQELLDFT 233

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
da	NP_001356956.1	HLH	560..613	CDD:197674	17/52 (33%)
ASCL1	NP_004307.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..98		14/95 (15%)
		bHLH_TS_ASCL1_Mash1	115..185	CDD:381585	23/96 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910