DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment da and ascl1a

DIOPT Version :9

Sequence 1:	NP_001356956.1	Gene:	da / 34413	FlyBaseID:	FBgn0267821	Length:	775	Species:	Drosophila melanogaster
Sequence 2:	NP_571294.1	Gene:	ascl1a / 30466	ZFINID:	ZDB-GENE-980526-90	Length:	196	Species:	Danio rerio

Alignment Length:	198	Identity:	46/198 - (23%)
Similarity:	71/198 - (35%)	Gaps:	50/198 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   499 SLDISDTKPTSSIESSNSGLQQHSQGKGTKRPRRYCSSADEDDDAEPAVKAIREKERRQ------ 557
            |:.:|   ||.|         |.|....:|:.:|..||:.|         .:|.|.|..
Zfish    27 SIQLS---PTDS---------QCSNKSASKQAKRQRSSSPE---------LLRCKRRLNFAGFGY 70

  Fly   558 -----------ANNARERIRIRDINEALKELGRMCMTHLKSDKPQTKLGILNMAVEVIMTLEQQV 611
                       ..|.|||.|::.:|.....| |..:.:..::|..:|:..|..|||.|..|:|.:
Zfish    71 SLPQQQPHAVARRNERERNRVKLVNNGFATL-REHVPNGAANKKMSKVETLRSAVEYIRALQQLL 134

  Fly   612 RERNLNPKAACLKRREEEKAEDGPKLSAQHHMIPQPQQVGGTPGSSYHSQPAQLVP--PSSQTIS 674
            .|.:....|.       :.....|.:|..:.  .....:.|:|.|||.|......|  |..|.:.
Zfish   135 DEHDAVSAAF-------QSGVLSPTISQNYS--NDMNSMAGSPVSSYSSDEGSYDPLSPEEQELL 190

  Fly   675 TMT 677
            ..|
Zfish   191 DFT 193

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
da	NP_001356956.1	HLH	560..613	CDD:197674	17/52 (33%)
ascl1a	NP_571294.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	33..54		8/29 (28%)
		HLH	94..136	CDD:197674	12/42 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	159..186		8/26 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910