Protein Alignment da and tcf3a

DIOPT Version :9

• Sequence 1: NP_001356956.1
• Gene: da / 34413
• FlyBaseID: FBgn0267821
• Length: 775
• Species: Drosophila melanogaster
• Sequence 2: NP_571169.1
• Gene: tcf3a / 30310
• ZFINID: ZDB-GENE-990415-51
• Length: 583
• Species: Danio rerio
• Alignment Length: 684
• Identity: 202/684 - (29%)
• Similarity: 275/684 - (40%)
• Gaps: 201/684 - (29%)

  Fly    58 DFNSM--HDTVNG---GNNRYANASTVDQYFDSAAAGSGGAWCQPQMSSANS-YMGQSAYQNSGP 116
            ||:.|  |...||   |.|..::...:|...||      |:|    .|.||| ..|...|.:
Zfish    15 DFSIMFPHPMSNGKSRGPNIPSSQFGLDDRNDS------GSW----GSEANSPSFGARLYGD--- 66

  Fly   117 LSGHSIDQQQQQVH-QADGLGMGG-------------------GGGGGVGADGMHCP-------- 153
              ||...:.....: :.||....|                   ...|..|:...:.|
Zfish    67 --GHHYPEHDNMYNLEIDGKSERGYPVTQLLPGEINIAASDALSPPGMKGSSQFYSPHRRRPAES 129

  Fly   154 ----------VTTGLPPISSFRPTSGG-------IGGPGA--GQQAPVNVNVN------------ 187
                      |..|||...|..|.|.|       .|.||:  |...|...||.
Zfish   130 SIDPLPKKRKVPHGLPTSISAYPGSTGDDYNQDSAGYPGSKPGNLYPGFFNVQEGLPDHWGQSGY 194

  Fly   188 PPAVFN--SPQAHNHNHTVQAQHSALSTAGPLGHHSLNHTPHAHSHTLPLP-HALPHGHTLPHPH 249
            ||.:.|  :||...                ||.....|:..|.....||.. |::|.|:.:|:
Zfish   195 PPVMSNFINPQKPQ----------------PLPVSPQNYPLHGSEVNLPSSFHSVPAGYGVPN-- 241

  Fly   250 HSQQNSPAVQSSDAFSG-AGASVKVAGAGNSSAAALRQQMYMPADQSISSFGSNPSTPVNSPPPL 313
                ::|.:.||:...| .||:...:||....|.|   .:| |:|.:.|:|.|.|||||.||..:
Zfish   242 ----HTPPISSSEGIMGNRGANAGSSGAEIGKALA---SIY-PSDNNGSNFSSTPSTPVGSPSNV 298

  Fly   314 TQSVVGGGGEPSVSGGSGWGHSVLNGGPSSSYASEMVPVSSLHTMASVFQGVRMEERLDDALNVL 378
            ..|            .|.|........||..:.            |.:.|. ::::||.:||:||
Zfish   299 AAS------------ASQWPKGSSQPAPSPGFE------------AGLAQS-KLDDRLGEALHVL 338

  Fly   379 RNHCEPEMLAGVNQSLASIDNIDALTSFVPNSPSHLGSGGNSGSVSNTSNAALVHEVLALGAAAA 443
            |||      ..|...:.|:     |::.:        ||.::|                   |||
Zfish   339 RNH------HAVGTDMQSL-----LSAAI--------SGHSAG-------------------AAA 365

  Fly   444 AGTSGQSVGGAGSLASLKLDRSA-STSLPKQTKKRKEHTAISNSVPAGVSTTSSLTSLDI----- 502
            .|:..|:.|.|..|..|..:.|. :..||:.:...:.|.......|:..|.|  .|||.:
Zfish   366 LGSLRQAFGLANRLPGLMSNHSEDAAGLPQSSALLQGHHTSHQPPPSSQSDT--FTSLSLARSSH 428

  Fly   503 ---SDTKPTSSIESSNSGLQQHSQGKGTKRPRRYCSSADEDDDAEP-----AVKAIREKERRQAN 559
               ||.|.....:..|..:...|:.:......|..:|.|||:|.:.     .|||.||:|||.||
Zfish   429 ASSSDIKREDKDDDENLSIADKSEDEKKDGKSRTRTSQDEDEDEDDEDLPVEVKAERERERRMAN 493

  Fly   560 NARERIRIRDINEALKELGRMCMTHLKSDKPQTKLGILNMAVEVIMTLEQQVRERNLNPKAACLK 624
            |||||:|:||||||.|||||||..||.::||||||.||:.||.||:.||||||||||||||||||
Zfish   494 NARERLRVRDINEAFKELGRMCQLHLSNEKPQTKLLILHQAVNVILNLEQQVRERNLNPKAACLK 558

  Fly   625 RREEEKAEDGPKLSAQHHMIPQPQQVGGTPGSSY 658
            ||||||            :..:.|.:.|..|..:
Zfish   559 RREEEK------------VTGEAQMLSGLGGDGH 580

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
da	NP_001356956.1	HLH	560..613	CDD:197674	38/52 (73%)
tcf3a	NP_571169.1	HLH	494..547	CDD:197674	38/52 (73%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583913
Domainoid	1	1.000	85	1.000	Domainoid score	I8119
eggNOG	1	0.900	-	-		E1_KOG3910
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	207	1.000	Inparanoid score	I3676
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D260626at33208
OrthoFinder	1	1.000	-	-		FOG0001459
OrthoInspector	1	1.000	-	-		otm24503
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11793
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1175
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	13	13.360