DRSC/TRiP Functional Genomics Resources

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Protein Alignment da and Tcf4

DIOPT Version :9

Sequence 1:NP_001356956.1 Gene:da / 34413 FlyBaseID:FBgn0267821 Length:775 Species:Drosophila melanogaster
Sequence 2:NP_001348056.1 Gene:Tcf4 / 21413 MGIID:98506 Length:670 Species:Mus musculus


Alignment Length:735 Identity:216/735 - (29%)
Similarity:293/735 - (39%) Gaps:220/735 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 IANKQPTGTVGADRG-----GGGGYHSP---YG-----------SLGVENGMYPSDFNS--MHDT 65
            :|:...||:...||.     |.||:.||   ||           .||..:.:.|...||  ...|
Mouse    40 LASGHFTGSNVEDRSSSGSWGTGGHPSPSRNYGDGTPYDHMTSRDLGSHDNLSPPFVNSRIQSKT 104

  Fly    66 VNGGNNRYANASTVDQYFDSAAAG----SGGAWCQPQMSSANSYMGQSAYQNSGPLSGHSIDQQQ 126
            ..|..:.|...:....:..|...|    .......|....:..|...|......||...:::.|.
Mouse   105 ERGSYSSYGRENVQGCHQQSLLGGDMDMGNPGTLSPTKPGSQYYQYSSNNARRRPLHSSAMEVQT 169

  Fly   127 QQVHQADGLGMGGGGGGGVGADGMHCPVTTGLPPISSFRPTSG----GIGGPGAGQQAPVNVNVN 187
            ::|.:                      |..|||. |.:.|::.    ....||.....|. .:..
Mouse   170 KKVRK----------------------VPPGLPS-SVYAPSASTADYNRDSPGYPSSKPA-ASTF 210

  Fly   188 PPAVFNSPQAHNHNHTVQAQHSALST---AGPLGHHSLNHTPHAHSHTLPLPHALPHGHTLPHPH 249
            |.:.|  .|..:|:....:..|.::.   .|.||:.|  |.|.:.|:....||     ..|.:|.
Mouse   211 PSSFF--MQDGHHSSDPWSSSSGMNQPGYGGMLGNSS--HIPQSSSYCSLHPH-----ERLSYPS 266

  Fly   250 HSQQN------------------------SPAVQSSDAF-----SGAGASVKVAGAGNSSAAALR 285
            ||..:                        :|....:|:.     :||..|.:...|...:.|:: 
Mouse   267 HSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGTGAAGSSQTGDALGKALASI- 330

  Fly   286 QQMYMPADQSISSFGSNPSTPVNSPPPLTQSVVGGGGEPSVSGGSGWGHSVLNGGPSSSYASEMV 350
               |.| |.:.:||.|||||||.|||.|:            :|.:.|..   |||.:||..:...
Mouse   331 ---YSP-DHTNNSFSSNPSTPVGSPPSLS------------AGTAVWSR---NGGQASSSPNYEG 376

  Fly   351 PVSSLHTMASVFQGVRME---ERLDDALNVLRNHCEPEMLAGVNQSLASIDNIDALTSFVPN--- 409
            |:.||.:        |:|   ||||||::|||||       .|..|.|           ||.   
Mouse   377 PLHSLQS--------RIEDRLERLDDAIHVLRNH-------AVGPSTA-----------VPGGHG 415

  Fly   410 ------SPSHLGSGGNSGSVSNTSNAALVHEVLALGAAAAAGTSGQSVGGAGSLASLKLDRSAST 468
                  .|||.|:.|:.||...||..:.....|.:||....|.:                     
Mouse   416 DMHGIMGPSHNGAMGSLGSGYGTSLLSANRHSLMVGAHREDGVA--------------------- 459

  Fly   469 SLPKQTKKRKEHTAISNSVPAGVSTTSSLTSLDISDTKPT----------SSIESSNSGLQQHSQ 523
                   .|..|:.:.|.||.......|.||.|::..:..          .|:.|.:|.::...:
Mouse   460 -------LRGSHSLLPNQVPVPQLPVQSATSPDLNPPQDPYRGMPPGLQGQSVSSGSSEIKSDDE 517

  Fly   524 G-------------------KGTKRPRRYCSSADEDDDAEPAVKAIREKERRQANNARERIRIRD 569
            |                   |..|...|..||.::|:|..|..||.||||||.|||||||:|:||
Mouse   518 GDENLQDTKSSEDKKLDDDKKDIKSITRSRSSNNDDEDLTPEQKAEREKERRMANNARERLRVRD 582

  Fly   570 INEALKELGRMCMTHLKSDKPQTKLGILNMAVEVIMTLEQQVRERNLNPKAACLKRREEEK-AED 633
            ||||.||||||...|||||||||||.||:.||.||::|||||||||||||||||||||||| :.:
Mouse   583 INEAFKELGRMVQLHLKSDKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSSE 647

  Fly   634 GPKLS----------AQHHM 643
            .|.||          |.:||
Mouse   648 PPPLSLAGPHPGMGDAANHM 667

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
daNP_001356956.1 HLH 560..613 CDD:197674 40/52 (77%)
Tcf4NP_001348056.1 Essential for MYOD1 inhibition 1..83 12/42 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 24..244 46/229 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 262..320 9/57 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 335..378 20/57 (35%)
Leucine-zipper 378..399 10/28 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 406..426 6/30 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 465..573 28/107 (26%)
bHLH_E-protein_TCF4_E2-2 561..645 CDD:381515 69/83 (83%)
Class A specific domain 622..645 22/22 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 637..670 13/31 (42%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167839825
Domainoid 1 1.000 89 1.000 Domainoid score I7828
eggNOG 1 0.900 - - E1_KOG3910
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 213 1.000 Inparanoid score I3623
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D260626at33208
OrthoFinder 1 1.000 - - FOG0001459
OrthoInspector 1 1.000 - - otm42772
orthoMCL 1 0.900 - - OOG6_105744
Panther 1 1.100 - - O PTHR11793
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4532
SonicParanoid 1 1.000 - - X1175
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1514.790

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