DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment da and Tcf12

DIOPT Version :9

Sequence 1:	NP_001356956.1	Gene:	da / 34413	FlyBaseID:	FBgn0267821	Length:	775	Species:	Drosophila melanogaster
Sequence 2:	NP_035674.2	Gene:	Tcf12 / 21406	MGIID:	101877	Length:	706	Species:	Mus musculus

Alignment Length:	761	Identity:	230/761 - (30%)
Similarity:	315/761 - (41%)	Gaps:	247/761 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 QPTGTVGADRGGGGGYHSPYGS-------LGVENGMYPSDFNSMHDTVNGGNNRYANASTVDQYF 83
            ||:.:..:.|   |...||:.|       ||...|:.|:.|  |:..:.|..:...:.|...:
Mouse    65 QPSPSYDSSR---GFTDSPHYSDHLNDSRLGTHEGLSPTPF--MNSNLIGKTSERGSFSLYSR-- 122

  Fly    84 DSAAAGSGGAWCQPQMSSANSYMGQSAYQNSGPLSG------HSIDQQQQQVHQADGLGMGGGGG 142
            ||..:|     ||..:...:..:|..|..:|....|      .:...:::.:|.:
Mouse   123 DSGLSG-----CQSSLLRQDLGLGSPAQLSSSGKPGTPYYSFSATSSRRRPLHDS---------- 172

  Fly   143 GGVGADGMHC----PVTTGL-------------------------PPISSFRPT----------- 167
              |..|.:..    .|..||                         ||.|.|..|
Mouse   173 --VALDPLQAKKVRKVPPGLPSSVYAPSPNSDDFNRESPSYPSPKPPTSMFASTFFMQDGTHSSS 235

  Fly   168 -----SGGIGGPGAGQQAPVNVNVNPPAVFNSPQAHNHNHTVQAQHSALSTAGPL-GHHSLNHTP 226
                 |.|:..||.|            .:..:..:|         .|..|:.|.| .|..|::.|
Mouse   236 DLWSSSNGMSQPGFG------------GILGTSTSH---------MSQSSSYGSLHSHDRLSYPP 279

  Fly   227 HAHSHT-----LPLPHALPHGHTLPHPHHSQQNSPAVQSSDAFSGA-GASVKVAGAGNSSAAALR 285
            |:.|.|     ||...:...|.|...|:.:..::|.:..||:..|. |.:...:..|::...||
Mouse   280 HSVSPTDINTSLPPMSSFHRGSTSSSPYVAASHTPPINGSDSILGTRGNAAGSSQTGDALGKAL- 343

  Fly   286 QQMYMPADQSISSFGSNPSTPVNSPPPLTQSVVGGGGEPSVSGGSGWGHSVLNGG--PSS-SYAS 347
            ..:|.| |.:.|||.|||||||.||.|||             |.|.|..:   ||  ||| ||.
Mouse   344 ASIYSP-DHTSSSFPSNPSTPVGSPSPLT-------------GTSQWPRA---GGQAPSSPSYE- 390

  Fly   348 EMVPVSSLHTMAS-------------------VFQGVRME---ERLDDALNVLRNHCEPEMLAGV 390
                 :|||::.:                   |.:..|||   :|||||::|||||.     .|.
Mouse   391 -----NSLHSLKNRVEQQLHEHLQDAMSFLKDVCEQSRMEDRLDRLDDAIHVLRNHA-----VGP 445

  Fly   391 NQSL-ASIDNIDALTSFVPNSPSHLGSGGN-------SGSVSNTSNAALV-------------HE 434
            :.|| .|..:|.:|.     .|||..|.||       |..|:|:.:|::|             |.
Mouse   446 STSLPTSHSDIHSLL-----GPSHNASIGNLNSNYGGSSLVTNSRSASMVGTHREDSVSLNGNHS 505

  Fly   435 VLALGAAAA-------------AGTSGQSVGGAGSLASLKLDRSASTSLPKQTKKRKEHTAISNS 486
            ||:...||:             .|...||    ||:        ..|.:..:.|::.|:.   :.
Mouse   506 VLSSTVAASNTELNHKTPENFRGGVQNQS----GSV--------VPTEIKTENKEKDENL---HE 555

  Fly   487 VPAGVSTTSSLTSLDISDTKPTSSIESSNSGLQQHSQGKGTKRPRRYCSSADEDDDAEPAVKAIR 551
            .|:.            .|.|  |..|||...::..|:|:        .||.:||:|..|..|..|
Mouse   556 PPSS------------DDMK--SDDESSQKDIKVSSRGR--------TSSTNEDEDLNPEQKIER 598

  Fly   552 EKERRQANNARERIRIRDINEALKELGRMCMTHLKSDKPQTKLGILNMAVEVIMTLEQQVRERNL 616
            |||||.|||||||:|:||||||.|||||||..||||:||||||.||:.||.||::||||||||||
Mouse   599 EKERRMANNARERLRVRDINEAFKELGRMCQLHLKSEKPQTKLLILHQAVAVILSLEQQVRERNL 663

  Fly   617 NPKAACLKRREEEKAEDGPKLSAQHHMIPQPQQVGGTPGSSYHSQP 662
            ||||||||||||||..   ..||:    |.....|..||.|..:.|
Mouse   664 NPKAACLKRREEEKVS---AASAE----PPNTLPGAHPGLSESTNP 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
da	NP_001356956.1	HLH	560..613	CDD:197674	40/52 (77%)
Tcf12	NP_035674.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	25..109		13/48 (27%)
		Leucine-zipper	119..140		5/27 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	140..222		13/93 (14%)
		Nuclear localization signal. /evidence=ECO:0000255	181..188		1/6 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..313		17/84 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	349..392		27/65 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	520..604		29/120 (24%)
		bHLH_E-protein_TCF4_E2-2	595..679	CDD:381515	68/83 (82%)
		Class A specific domain	656..679		22/22 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	674..706		12/36 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839823
Domainoid	1	1.000	89	1.000	Domainoid score	I7828
eggNOG	1	0.900	-	-		E1_KOG3910
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	213	1.000	Inparanoid score	I3623
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001459
OrthoInspector	1	1.000	-	-		otm42772
orthoMCL	1	0.900	-	-		OOG6_105744
Panther	1	1.100	-	-	LDO	PTHR11793
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4532
SonicParanoid	1	1.000	-	-		X1175
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.780