DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment da and tcf4

DIOPT Version :9

Sequence 1:	NP_001356956.1	Gene:	da / 34413	FlyBaseID:	FBgn0267821	Length:	775	Species:	Drosophila melanogaster
Sequence 2:	XP_021324617.1	Gene:	tcf4 / 100526651	ZFINID:	ZDB-GENE-090814-1	Length:	496	Species:	Danio rerio

Alignment Length:	471	Identity:	116/471 - (24%)
Similarity:	176/471 - (37%)	Gaps:	135/471 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 GADRGGGGGYHSPYGSLGVENGMYPSDFNSMHDTVN---------GGNNR----YANASTVDQYF 83
            |...|.|......|......:.|...|..| ||:::         |.:.|    |...|::  :.
Zfish    76 GTSWGNGVRATKNYADGSQYSHMTGRDLGS-HDSISPPYSNARLAGKSERVSYSYGRDSSI--HC 137

  Fly    84 DSAAAGSGGAWCQPQMSSANSYMGQSAYQNSG------PLSGHSIDQQQQQVHQADGLGMGGGGG 142
            .|...|.......|:..|... :|...||:.|      .|...|::.|.::|.:
Zfish   138 QSGLMGGEVGMVSPETVSPTK-LGSQYYQHYGXKPRRRTLHSDSMEVQTKKVRK----------- 190

  Fly   143 GGVGADGMHCPVTTGLPPISSFRPTSG----GIGGPG-AGQQAPVNVNVNPPAVFNSPQAHNHNH 202
                       |..|||. |.:.|::.    ....|| ...:||   ..:.|:.|..|..|   |
Zfish   191 -----------VPPGLPS-SVYAPSASTADYNRDSPGYPSSKAP---GSSFPSSFFMPDGH---H 237

  Fly   203 TVQAQHSALSTAGPLGHHSL--NHTPHAHSHTLPLPHALPHGHTLPHPHHSQ-QNSPAVQSSDAF 264
            :.....|:.|...| |::|:  |.|..|.|.:....|  ||.. |.:|.||. :.:|::....:|
Zfish   238 STDPWSSSGSMNQP-GYNSMLGNSTHSAQSSSYCGLH--PHDR-LSYPSHSSAEINPSLPPMSSF 298

  Fly   265 ------------------------------SGAGASVKVAGAGNSSAAALRQQMYMPADQSISSF 299
                                          |.||:|.:...|...:.|::..|:|.| |.:.:||
Zfish   299 HRSGGSSHYSTASCSATTNGTDSTMANRSSSAAGSSSQTGDALGKALASVSLQIYSP-DHTNNSF 362

  Fly   300 GSNPSTPVNSPPPLTQSVVGGGGEPSVSGGSGWGHSVLNGGPSSSYASEMVPVSSLHTMASVFQG 364
            .|||||||.|||.||           .:..:.|..   ||..:||.:.|    ..||::.|
Zfish   363 SSNPSTPVGSPPALT-----------AASTAVWSR---NGQGASSPSYE----PPLHSLQS---- 405

  Fly   365 VRME---ERLDDALNVLRNHC--EPEMLAGVNQSLASIDNIDALTSFVPNSPSHLGSGGNSGSVS 424
             |:|   ||||||::|||:|.  ....:||.:..:..:         :..|.||.|:.|...|..
Zfish   406 -RIEDRLERLDDAIHVLRSHAVGPSTAMAGAHADMHGL---------ITPSHSHNGAMGGYSSGL 460

  Fly   425 NTSNAALVHEVLALGA 440
            ..||.   |.::..||
Zfish   461 LPSNR---HSLMVRGA 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
da	NP_001356956.1	HLH	560..613	CDD:197674
tcf4	XP_021324617.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D260626at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010