Protein Alignment da and tcf12

DIOPT Version :9

• Sequence 1: NP_001356956.1
• Gene: da / 34413
• FlyBaseID: FBgn0267821
• Length: 775
• Species: Drosophila melanogaster
• Sequence 2: XP_004912760.1
• Gene: tcf12 / 100188922
• XenbaseID: XB-GENE-5799694
• Length: 716
• Species: Xenopus tropicalis
• Alignment Length: 743
• Identity: 228/743 - (30%)
• Similarity: 324/743 - (43%)
• Gaps: 161/743 - (21%)

  Fly    15 FQNCFNKIANK---QPTGTVGADRGGGGGYHSPYG-SLGVENGMYPSDFNSMHDTVNGGNNRYAN 75
            |...|:...|.   :|| |:|:.:..|.|.....| |.|....:.||..:|...|   .:..|:
 Frog    36 FHTMFSPPVNSGKTRPT-TLGSSQFSGSGMDERSGASWGTSGQLSPSYESSRGFT---DSPHYS- 95

  Fly    76 ASTVDQYFDSAAAGSGGAWCQPQMSSANSYMGQSAYQNSGPLSGH--SIDQQQQQVHQADGLGMG 138
                |...||......|....|.|:|  :.||:::.:...||.|.  ::...|..:.:|| :|:|
 Frog    96 ----DHLNDSRLGPHEGLSPTPFMNS--NLMGKTSDRGPFPLFGRDSAVPGCQPGLVRAD-IGLG 153

  Fly   139 GGG----GGGVG--------ADGMHCPV--TTGLPPISSFR--------PTSGGIGGPGA---GQ 178
            ..|    .|..|        :.....|:  |..|.|:.:.:        |:|.....|.:   .:
 Frog   154 SSGQLPSSGKPGSPYFPFSASSSRRRPLQDTPALDPVQTKKIRKVPPGLPSSVYAPSPNSDDFNR 218

  Fly   179 QAPVNVNVNPPA------------VFNSPQAHNHNHTVQ---------AQHSALSTAGPLG--HH 220
            ::|...:..||:            ..||.:..|.::.:.         :..|.:|.:...|  |.
 Frog   219 ESPSYPSPKPPSSMFASTFFLQDGTHNSSELWNSSNGISQPGYGGMLGSSSSHMSQSSSFGSLHD 283

  Fly   221 SLNHTPHAHSHT-----LPLPHALPHGHTLPHPHHSQQNSPAVQSSDAFSG-----AGASVKVAG 275
            .||:.||..|.|     ||...:...|......:.:..::|.:..||...|     ||:|.....
 Frog   284 RLNYPPHPVSPTDINASLPPMSSFHRGGNSSSTYVAASHTPPINGSDNLLGNRGNAAGSSQTGDA 348

  Fly   276 AGNSSAAALRQQMYMPADQSISSFGSNPSTPVNSPPPLTQSVVGGGGEPSVSGGSGWGHSVLNGG 340
            .|.:.|:     :|.| |.:.|||.||||||..||.||             .|.:.|...   ||
 Frog   349 LGKALAS-----IYSP-DHTSSSFPSNPSTPGGSPSPL-------------PGANQWSRP---GG 391

  Fly   341 --PSS-SYASEMVPVSSLHTMAS-------------------VFQGVRME---ERLDDALNVLRN 380
              ||| ||.      :|||::.:                   |.:..|||   :|||||::||||
 Frog   392 QTPSSPSYE------NSLHSLKNRVEQQLHEHLQDAMSFLKDVCEQSRMEDRLDRLDDAIHVLRN 450

  Fly   381 HCEPEMLAGVNQSLASIDNIDALTSFVPNSP--SHLGSGGNSGSVSNTSNAALVHEVLALGAAAA 443
            |.     .|.:.|:|:  :|.:|.....|.|  |...:.|.:|.|:|:...::  :|......:.
 Frog   451 HA-----VGPSTSMAA--DIHSLLGAAHNGPIASLTSNYGTAGLVANSRQTSM--QVANHREESV 506

  Fly   444 AGTSGQSVGGAGSLASLKLDRSASTSLPKQTKKRKEHTAISNSVPAGVSTTSSLTSLDI----SD 504
            :.:|..||          |..:.|.|.|:.|.|.:|:....:.|....|..|:|..:..    .|
 Frog   507 SISSEHSV----------LSSTVSASNPEITHKPQENYRALSGVLTAQSVISNLAEIKTEHKEKD 561

  Fly   505 TKPTSSIESSNSGLQQHSQGKGTKRPRRYCSSADEDDDAEPAVKAIREKERRQANNARERIRIRD 569
            ......:.|.:......|..|..|..|...||.:||:|..|..|..||||||.|||||||:|:||
 Frog   562 ENIHDGVSSDDMKSDDESSQKDFKSSRGRTSSINEDEDLNPEQKLEREKERRMANNARERLRVRD 626

  Fly   570 INEALKELGRMCMTHLKSDKPQTKLGILNMAVEVIMTLEQQVRERNLNPKAACLKRREEEKAEDG 634
            ||||.|||||||..||||:||||||.||:.||.||:.||||||||||||||||||||||||..
 Frog   627 INEAFKELGRMCQLHLKSEKPQTKLLILHQAVAVILNLEQQVRERNLNPKAACLKRREEEKVS-- 689

  Fly   635 PKLSAQHHMIPQPQQVGGTPGSSYHSQP 662
             .:||:    |.....|..||.:..:.|
 Frog   690 -AVSAE----PPNTHPGAHPGLTDTTNP 712

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
da	NP_001356956.1	HLH	560..613	CDD:197674	40/52 (77%)
tcf12	XP_004912760.1	bHLH_E-protein_TCF4_E2-2	605..689	CDD:381515	68/83 (82%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	84	1.000	Domainoid score	I8128
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	208	1.000	Inparanoid score	I3593
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D260626at33208
OrthoFinder	1	1.000	-	-		FOG0001459
OrthoInspector	1	1.000	-	-		otm47878
Panther	1	1.100	-	-	LDO	PTHR11793
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4532
SonicParanoid	1	1.000	-	-		X1175
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.100