Protein Alignment Cdk1 and Cdk4

DIOPT Version :10

• Sequence 1: NP_476797.1
• Gene: Cdk1 / 34411
• FlyBaseID: FBgn0004106
• Length: 297
• Species: Drosophila melanogaster
• Sequence 2: NP_446045.1
• Gene: Cdk4 / 94201
• RGDID: 621120
• Length: 303
• Species: Rattus norvegicus
• Alignment Length: 300
• Identity: 118/300 - (39%)
• Similarity: 182/300 - (60%)
• Gaps: 16/300 - (5%)

  Fly     4 FEKIEKIGEGTYGVVYKGRNRLTGQIVAMKKIRLESDDE---GVPSTAIREISLLKEL---KHEN 62
            :|.:.:||.|.||.|||.|:..:|..||:|.:|:.:...   |:|.:.:||::||:.|   :|.|
  Rat     6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGAAGGGLPVSTVREVALLRRLEAFEHPN 70

  Fly    63 IVCLEDVLM-----EENRIYLIFEFLSMDLKKYMDSLPVDKHMESELVRSYLYQITSAILFCHRR 122
            :|.|.||..     .:.::.|:||.:..||:.|:|..| ...:..|.::..:.|..|.:.|.|..
  Rat    71 VVRLMDVCATSRTDRDIKVTLVFEHIDQDLRTYLDKAP-PPGLPVETIKDLMRQFLSGLDFLHAN 134

  Fly   123 RVLHRDLKPQNLLIDKSGLIKVADFGLGRSFGIPVRIYTHEIVTLWYRAPEVLLGSPRYSCPVDI 187
            .::||||||:|:|:..:|.:|:|||||.|.:...:.: |..:||||||||||||.| .|:.|||:
  Rat   135 CIVHRDLKPENILVTSNGTVKLADFGLARIYSYQMAL-TPVVVTLWYRAPEVLLQS-TYATPVDM 197

  Fly   188 WSIGCIFAEMATRKPLFQGDSEIDQLFRMFRILKTPTEDIWPGVTSLPDYKNTFPCWSTNQLTNQ 252
            ||:|||||||..|||||.|:||.|||.::|.::..|.||.||...|||  :..|.......:.:.
  Rat   198 WSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPREVSLP--RGAFSPRGPRPVQSV 260

  Fly   253 LKNLDANGIDLIQKMLIYDPVHRISAKDILEHPYFNGFQS 292
            :..::.:|..|:.:||.::|:.||||...|:|.|.:..:|
  Rat   261 VPEMEESGAQLLLEMLTFNPLKRISAFRALQHSYLHKEES 300

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk1	NP_476797.1	STKc_CDK1_euk	3..287	CDD:270845	116/293 (40%)
Cdk4	NP_446045.1	Protein Kinases, catalytic domain	5..295	CDD:473864	116/293 (40%)
		Required for binding D-type cyclins. /evidence=ECO:0000250	50..56		1/5 (20%)