DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdk1 and CDC28

DIOPT Version :9

Sequence 1:	NP_476797.1	Gene:	Cdk1 / 34411	FlyBaseID:	FBgn0004106	Length:	297	Species:	Drosophila melanogaster
Sequence 2:	NP_009718.3	Gene:	CDC28 / 852457	SGDID:	S000000364	Length:	298	Species:	Saccharomyces cerevisiae

Alignment Length:	291	Identity:	170/291 - (58%)
Similarity:	227/291 - (78%)	Gaps:	4/291 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEDFEKIEKIGEGTYGVVYKGRNRLTGQ---IVAMKKIRLESDDEGVPSTAIREISLLKELKHEN 62
            :.:::::||:||||||||||..:...||   :||:|||||||:|||||||||||||||||||.:|
Yeast     5 LANYKRLEKVGEGTYGVVYKALDLRPGQGQRVVALKKIRLESEDEGVPSTAIREISLLKELKDDN 69

  Fly    63 IVCLEDVL-MEENRIYLIFEFLSMDLKKYMDSLPVDKHMESELVRSYLYQITSAILFCHRRRVLH 126
            ||.|.|:: .:.:::||:||||.:|||:||:.:|.|:.:.:::|:.::.|:...|.:||..|:||
Yeast    70 IVRLYDIVHSDAHKLYLVFEFLDLDLKRYMEGIPKDQPLGADIVKKFMMQLCKGIAYCHSHRILH 134

  Fly   127 RDLKPQNLLIDKSGLIKVADFGLGRSFGIPVRIYTHEIVTLWYRAPEVLLGSPRYSCPVDIWSIG 191
            ||||||||||:|.|.:|:.||||.|:||:|:|.||||||||||||||||||..:||..||.||||
Yeast   135 RDLKPQNLLINKDGNLKLGDFGLARAFGVPLRAYTHEIVTLWYRAPEVLLGGKQYSTGVDTWSIG 199

  Fly   192 CIFAEMATRKPLFQGDSEIDQLFRMFRILKTPTEDIWPGVTSLPDYKNTFPCWSTNQLTNQLKNL 256
            ||||||..|||:|.|||||||:|::||:|.||.|.|||.:..|||:|.:||.|....|:..:.:|
Yeast   200 CIFAEMCNRKPIFSGDSEIDQIFKIFRVLGTPNEAIWPDIVYLPDFKPSFPQWRRKDLSQVVPSL 264

  Fly   257 DANGIDLIQKMLIYDPVHRISAKDILEHPYF 287
            |..||||:.|:|.|||::||||:....||||
Yeast   265 DPRGIDLLDKLLAYDPINRISARRAAIHPYF 295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdk1	NP_476797.1	STKc_CDK1_euk	3..287	CDD:270845	168/287 (59%)
CDC28	NP_009718.3	STKc_CDK1_CdkB_like	8..295	CDD:270829	168/286 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346226
Domainoid	1	1.000	364	1.000	Domainoid score	I124
eggNOG	1	0.900	-	-		E1_KOG0594
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	364	1.000	Inparanoid score	I374
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000411
OrthoInspector	1	1.000	-	-		oto99181
orthoMCL	1	0.900	-	-		OOG6_100334
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R185
SonicParanoid	1	1.000	-	-		X960
TreeFam	1	0.960	-	-
	11	10.680