DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdk1 and CDK14

DIOPT Version :9

Sequence 1:	NP_476797.1	Gene:	Cdk1 / 34411	FlyBaseID:	FBgn0004106	Length:	297	Species:	Drosophila melanogaster
Sequence 2:	NP_001274064.1	Gene:	CDK14 / 5218	HGNCID:	8883	Length:	469	Species:	Homo sapiens

Alignment Length:	292	Identity:	137/292 - (46%)
Similarity:	197/292 - (67%)	Gaps:	9/292 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EDFEKIEKIGEGTYGVVYKGRNRLTGQIVAMKKIRLESDDEGVPSTAIREISLLKELKHENIVCL 66
            :.:||:||:|||:|..||||::::.|::||:|.|||: ::||.|.|||||.||||.|||.|||.|
Human   133 DSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQ-EEEGTPFTAIREASLLKGLKHANIVLL 196

  Fly    67 EDVLMEENRIYLIFEFLSMDLKKYMDSLPVDKHMESELVRSYLYQITSAILFCHRRRVLHRDLKP 131
            .|::..:..:.|:||::..||.:|||..|...|.::  |:.:|:|:...:.:.|:|.:|||||||
Human   197 HDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDN--VKLFLFQLLRGLSYIHQRYILHRDLKP 259

  Fly   132 QNLLIDKSGLIKVADFGLGRSFGIPVRIYTHEIVTLWYRAPEVLLGSPRYSCPVDIWSIGCIFAE 196
            |||||..:|.:|:|||||.|:..:|...|::|:||||||.|:|||||..||..:|:|.:||||.|
Human   260 QNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVE 324

  Fly   197 MATRKPLFQGDSEI-DQLFRMFRILKTPTEDIWPGVTSLPDYK-NTFPCWSTNQLT---NQLKNL 256
            |......|.|..:| |||.|:|.:|.||.||.||||.|||.:| ..|..:|:..|.   |:|..:
Human   325 MIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSSKNLRQAWNKLSYV 389

  Fly   257 DANGIDLIQKMLIYDPVHRISAKDILEHPYFN 288
            : :..||..|:|...|.:|:||:..|.|.||:
Human   390 N-HAEDLASKLLQCSPKNRLSAQAALSHEYFS 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdk1	NP_476797.1	STKc_CDK1_euk	3..287	CDD:270845	135/288 (47%)
CDK14	NP_001274064.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	103..133		137/292 (47%)
		STKc_PFTAIRE1	129..431	CDD:143374	137/292 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	449..469
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0594
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1010560at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820