DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cdk1 and Cdk5

DIOPT Version :9

Sequence 1:	NP_476797.1	Gene:	Cdk1 / 34411	FlyBaseID:	FBgn0004106	Length:	297	Species:	Drosophila melanogaster
Sequence 2:	NP_031694.1	Gene:	Cdk5 / 12568	MGIID:	101765	Length:	292	Species:	Mus musculus

Alignment Length:	292	Identity:	166/292 - (56%)
Similarity:	222/292 - (76%)	Gaps:	5/292 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEDFEKIEKIGEGTYGVVYKGRNRLTGQIVAMKKIRLESDDEGVPSTAIREISLLKELKHENIVC 65
            |:.:||:|||||||||.|:|.:||.|.:|||:|::||:.|||||||:|:|||.|||||||:|||.
Mouse     1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVR 65

  Fly    66 LEDVLMEENRIYLIFEFLSMDLKKYMDSLPVDKHMESELVRSYLYQITSAILFCHRRRVLHRDLK 130
            |.|||..:.::.|:|||...|||||.||...|  ::.|:|:|:|:|:...:.|||.|.|||||||
Mouse    66 LHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGD--LDPEIVKSFLFQLLKGLGFCHSRNVLHRDLK 128

  Fly   131 PQNLLIDKSGLIKVADFGLGRSFGIPVRIYTHEIVTLWYRAPEVLLGSPRYSCPVDIWSIGCIFA 195
            ||||||:::|.:|:|||||.|:||||||.|:.|:||||||.|:||.|:..||..:|:||.|||||
Mouse   129 PQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFA 193

  Fly   196 EMATR-KPLFQGDSEIDQLFRMFRILKTPTEDIWPGVTSLPDYKNTFPCW-STNQLTNQLKNLDA 258
            |:|.. :|||.|:...|||.|:||:|.||||:.||.:|.||||| .:|.: :|..|.|.:..|:|
Mouse   194 ELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTKLPDYK-PYPMYPATTSLVNVVPKLNA 257

  Fly   259 NGIDLIQKMLIYDPVHRISAKDILEHPYFNGF 290
            .|.||:|.:|..:||.||||::.|:||||:.|
Mouse   258 TGRDLLQNLLKCNPVQRISAEEALQHPYFSDF 289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdk1	NP_476797.1	STKc_CDK1_euk	3..287	CDD:270845	162/285 (57%)
Cdk5	NP_031694.1	STKc_CDK5	3..286	CDD:143344	162/285 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1010560at2759
OrthoFinder	1	1.000	-	-		FOG0000411
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100334
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R185
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850