Protein Alignment Cdk1 and Cdk4

DIOPT Version :9

• Sequence 1: NP_476797.1
• Gene: Cdk1 / 34411
• FlyBaseID: FBgn0004106
• Length: 297
• Species: Drosophila melanogaster
• Sequence 2: NP_034000.1
• Gene: Cdk4 / 12567
• MGIID: 88357
• Length: 303
• Species: Mus musculus
• Alignment Length: 300
• Identity: 118/300 - (39%)
• Similarity: 181/300 - (60%)
• Gaps: 16/300 - (5%)

  Fly     4 FEKIEKIGEGTYGVVYKGRNRLTGQIVAMKKIRLESDDE---GVPSTAIREISLLKEL---KHEN 62
            :|.:.:||.|.||.|||.|:..:|..||:|.:|:.:...   |:|.:.:||::||:.|   :|.|
Mouse     6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGAAGGGLPVSTVREVALLRRLEAFEHPN 70

  Fly    63 IVCLEDVLM-----EENRIYLIFEFLSMDLKKYMDSLPVDKHMESELVRSYLYQITSAILFCHRR 122
            :|.|.||..     .:.::.|:||.:..||:.|:|..| ...:..|.::..:.|..|.:.|.|..
Mouse    71 VVRLMDVCATSRTDRDIKVTLVFEHIDQDLRTYLDKAP-PPGLPVETIKDLMRQFLSGLDFLHAN 134

  Fly   123 RVLHRDLKPQNLLIDKSGLIKVADFGLGRSFGIPVRIYTHEIVTLWYRAPEVLLGSPRYSCPVDI 187
            .::||||||:|:|:..:|.:|:|||||.|.:...:.: |..:||||||||||||.| .|:.|||:
Mouse   135 CIVHRDLKPENILVTSNGTVKLADFGLARIYSYQMAL-TPVVVTLWYRAPEVLLQS-TYATPVDM 197

  Fly   188 WSIGCIFAEMATRKPLFQGDSEIDQLFRMFRILKTPTEDIWPGVTSLPDYKNTFPCWSTNQLTNQ 252
            ||:|||||||..|||||.|:||.|||.::|.::..|.||.||...|||  :..|.......:.:.
Mouse   198 WSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPREVSLP--RGAFAPRGPRPVQSV 260

  Fly   253 LKNLDANGIDLIQKMLIYDPVHRISAKDILEHPYFNGFQS 292
            :..::.:|..|:.:||.::|..||||...|:|.|.:..:|
Mouse   261 VPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKEES 300

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk1	NP_476797.1	STKc_CDK1_euk	3..287	CDD:270845	116/293 (40%)
Cdk4	NP_034000.1	STKc_CDK4	5..295	CDD:143368	116/293 (40%)
		Required for binding D-type cyclins. /evidence=ECO:0000250	50..56		1/5 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0594
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810