Protein Alignment Cdk1 and CDK6

DIOPT Version :9

• Sequence 1: NP_476797.1
• Gene: Cdk1 / 34411
• FlyBaseID: FBgn0004106
• Length: 297
• Species: Drosophila melanogaster
• Sequence 2: NP_001138778.1
• Gene: CDK6 / 1021
• HGNCID: 1777
• Length: 326
• Species: Homo sapiens
• Alignment Length: 299
• Identity: 124/299 - (41%)
• Similarity: 191/299 - (63%)
• Gaps: 14/299 - (4%)

  Fly     2 EDFEKIEKIGEGTYGVVYKGRN-RLTGQIVAMKKIRLESDDEGVPSTAIREISLLKEL---KHEN 62
            :.:|.:.:||||.||.|:|.|: :..|:.||:|::|:::.:||:|.:.|||:::|:.|   :|.|
Human    11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPN 75

  Fly    63 IVCLEDVLM-----EENRIYLIFEFLSMDLKKYMDSLPVDKHMESELVRSYLYQITSAILFCHRR 122
            :|.|.||..     .|.::.|:||.:..||..|:|.:| :..:.:|.::..::|:...:.|.|..
Human    76 VVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVP-EPGVPTETIKDMMFQLLRGLDFLHSH 139

  Fly   123 RVLHRDLKPQNLLIDKSGLIKVADFGLGRSFGIPVRIYTHEIVTLWYRAPEVLLGSPRYSCPVDI 187
            ||:||||||||:|:..||.||:|||||.|.:...:.: |..:||||||||||||.| .|:.|||:
Human   140 RVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMAL-TSVVVTLWYRAPEVLLQS-SYATPVDL 202

  Fly   188 WSIGCIFAEMATRKPLFQGDSEIDQLFRMFRILKTPTEDIWPGVTSLPDYKNTFPCWSTNQLTNQ 252
            ||:|||||||..|||||:|.|::|||.::..::..|.|:.||...:||  :..|...|...:...
Human   203 WSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALP--RQAFHSKSAQPIEKF 265

  Fly   253 LKNLDANGIDLIQKMLIYDPVHRISAKDILEHPYFNGFQ 291
            :.::|..|.||:.|.|.::|..||||...|.||||...:
Human   266 VTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLE 304

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk1	NP_476797.1	STKc_CDK1_euk	3..287	CDD:270845	122/292 (42%)
CDK6	NP_001138778.1	STKc_CDK6	11..300	CDD:270846	122/293 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0594
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810