DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cdk1 and CDK2

DIOPT Version :9

Sequence 1:NP_476797.1 Gene:Cdk1 / 34411 FlyBaseID:FBgn0004106 Length:297 Species:Drosophila melanogaster
Sequence 2:XP_011536034.1 Gene:CDK2 / 1017 HGNCID:1771 Length:346 Species:Homo sapiens


Alignment Length:340 Identity:185/340 - (54%)
Similarity:227/340 - (66%) Gaps:59/340 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MEDFEKIEKIGEGTYGVVYKGRNRLTGQIVAMKKIRLESDDEGVPSTAIREISLLKELKHENIVC 65
            ||:|:|:|||||||||||||.||:|||::||:|||||:::.|||||||||||||||||.|.|||.
Human     1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVK 65

  Fly    66 LEDVLMEENRIYLIFEFLSMDLKKYMDS-----LPVDKHMESELVRSYLYQITSAILFCHRRRVL 125
            |.||:..||::||:||||..||||:||:     :|:      .|::|||:|:...:.|||..|||
Human    66 LLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPL------PLIKSYLFQLLQGLAFCHSHRVL 124

  Fly   126 HRDLKPQNLLIDKSGLIKVADFGLGRSFGIPVRIYTHEIVTLWYRAPEVLLGSPRYSCPVDIWSI 190
            |||||||||||:..|.||:|||||.|:||:|||.||||:|||||||||:|||...||..|||||:
Human   125 HRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSL 189

  Fly   191 GCIFAEM------------------------------------------------ATRKPLFQGD 207
            |||||||                                                .||:.||.||
Human   190 GCIFAEMHLVGTQHHARCCGEHRRNGRQSLCPLCSYLEVAASQGWGMTAVSTPYPVTRRALFPGD 254

  Fly   208 SEIDQLFRMFRILKTPTEDIWPGVTSLPDYKNTFPCWSTNQLTNQLKNLDANGIDLIQKMLIYDP 272
            ||||||||:||.|.||.|.:||||||:||||.:||.|:....:..:..||.:|..|:.:||.|||
Human   255 SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDP 319

  Fly   273 VHRISAKDILEHPYF 287
            ..|||||..|.||:|
Human   320 NKRISAKAALAHPFF 334

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cdk1NP_476797.1 STKc_CDK1_euk 3..287 CDD:270845 182/336 (54%)
CDK2XP_011536034.1 STKc_CDK2_3 3..334 CDD:270844 182/336 (54%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0594
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1010560at2759
OrthoFinder 1 1.000 - - FOG0000411
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100334
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R185
SonicParanoid 1 1.000 - - X960
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.750

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