DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG5096 and LRRC4B

DIOPT Version :9

Sequence 1:NP_723576.1 Gene:CG5096 / 34410 FlyBaseID:FBgn0032235 Length:491 Species:Drosophila melanogaster
Sequence 2:NP_001073926.1 Gene:LRRC4B / 94030 HGNCID:25042 Length:713 Species:Homo sapiens


Alignment Length:345 Identity:85/345 - (24%)
Similarity:140/345 - (40%) Gaps:100/345 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    50 CNCYIDTNLLDCSEK-LQD----------WLSAEDWEDLTNGNVVFKTINLEHNNLTSVPILPKY 103
            |:|....:.:.|:.: |.:          :|:.::     ||..|.:|...:|..          
Human    61 CSCSNQASRVICTRRDLAEVPASIPVNTRYLNLQE-----NGIQVIRTDTFKHLR---------- 110

  Fly   104 DVENLYLANNQIDSISVGAFQNLTELVTLDLSHNRLTSKVLVPDVFKGPFTVQDFESLENLKTLN 168
            .:|.|.|:.|.:..|.||||..|..|.||:|..||||:   ||        .|.||.|..|:.|.
Human   111 HLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTT---VP--------TQAFEYLSKLRELW 164

  Fly   169 LGYNDLHSLDADLFEHIPHIEELVLCSNSFHVIDQLSETAISGLQSLKILDVSYMEIDDLPDTIL 233
            |..|.:.|:.:..|..:|.:..|.|  .....::.:||.|..||.:|:.|::....:.|:|    
Human   165 LRNNPIESIPSYAFNRVPSLRRLDL--GELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIP---- 223

  Fly   234 HGPRDLEIFIAAGNLFNQLPKALKYATNLTSLVLNENPIENLIGDNVFPPLTKLTHLSMTFMSKL 298
                                       |||:||                   :|..|.:: .::|
Human   224 ---------------------------NLTALV-------------------RLEELELS-GNRL 241

  Fly   299 YKIGPGAFSELQSLTELILSDNKLLNEIDEEALSKNVTGGQYLDYPPLEKVYLNNCNVSTLPKEL 363
            ..|.||:|..|.||.:|.|...::.. |:..|..         |...||::.|::.|:.:||.:|
Human   242 DLIRPGSFQGLTSLRKLWLMHAQVAT-IERNAFD---------DLKSLEELNLSHNNLMSLPHDL 296

  Fly   364 LVRWDKLKALDLRFNPWNCD 383
            .....:|:.:.|..|||:|:
Human   297 FTPLHRLERVHLNHNPWHCN 316

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5096NP_723576.1 LRR_RI 69..378 CDD:238064 77/308 (25%)
leucine-rich repeat 85..104 CDD:275380 2/18 (11%)
LRR_8 105..174 CDD:290566 28/68 (41%)
leucine-rich repeat 105..128 CDD:275380 10/22 (45%)
leucine-rich repeat 129..163 CDD:275380 14/33 (42%)
LRR_8 163..222 CDD:290566 16/58 (28%)
leucine-rich repeat 164..187 CDD:275380 6/22 (27%)
leucine-rich repeat 188..214 CDD:275380 7/25 (28%)
leucine-rich repeat 215..238 CDD:275380 4/22 (18%)
leucine-rich repeat 239..261 CDD:275380 0/21 (0%)
LRR_8 260..322 CDD:290566 17/61 (28%)
leucine-rich repeat 262..286 CDD:275380 4/23 (17%)
leucine-rich repeat 287..311 CDD:275380 8/23 (35%)
leucine-rich repeat 346..369 CDD:275380 7/22 (32%)
leucine-rich repeat 370..388 CDD:275380 6/14 (43%)
LRRC4BNP_001073926.1 LRRNT 57..90 CDD:214470 4/28 (14%)
LRR <76..297 CDD:227223 75/309 (24%)
LRR 1 87..108 5/25 (20%)
leucine-rich repeat 88..111 CDD:275380 6/37 (16%)
LRR 2 111..132 9/20 (45%)
leucine-rich repeat 112..135 CDD:275380 10/22 (45%)
LRR 3 135..156 12/31 (39%)
leucine-rich repeat 136..159 CDD:275380 14/33 (42%)
LRR 4 159..180 6/20 (30%)
leucine-rich repeat 160..183 CDD:275380 6/22 (27%)
LRR 5 183..205 5/23 (22%)
leucine-rich repeat 184..208 CDD:275380 7/25 (28%)
LRR 6 208..229 7/51 (14%)
leucine-rich repeat 209..230 CDD:275380 9/70 (13%)
LRR 7 230..251 7/21 (33%)
leucine-rich repeat 231..254 CDD:275380 8/23 (35%)
LRR 8 254..275 6/30 (20%)
leucine-rich repeat 255..278 CDD:275380 6/32 (19%)
LRR 9 278..299 7/20 (35%)
leucine-rich repeat 279..300 CDD:275380 7/20 (35%)
LRRCT 311..361 CDD:214507 4/6 (67%)
I-set 364..453 CDD:254352
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 497..551
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 694..713
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.