DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG5096 and Slit3

DIOPT Version :9

Sequence 1:NP_723576.1 Gene:CG5096 / 34410 FlyBaseID:FBgn0032235 Length:491 Species:Drosophila melanogaster
Sequence 2:NP_112611.1 Gene:Slit3 / 83467 RGDID:69311 Length:1523 Species:Rattus norvegicus


Alignment Length:435 Identity:97/435 - (22%)
Similarity:164/435 - (37%) Gaps:113/435 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    87 INLEHNNLTSVPILPKYDVEN---LYLANNQIDSISVGAFQNLTELVTLDLSHNRL--------- 139
            ::|:.||:|.:..:....::|   |:|.:||:..|..||||:|.:|..|.|:.|:|         
  Rat    66 LDLDRNNITRITKMDFTGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQ 130

  Fly   140 -TSKVLVPDV------------FKGPFTVQD---------------FESLENLKTLNLGYNDLHS 176
             |.|:...|:            |:|...|::               |.:|.:|:.|.|..|::..
  Rat   131 STPKLTRLDLSENQIQGIPRKAFRGVTGVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISR 195

  Fly   177 LDADLFEHIPHIEELVLCSNSFH-------VIDQLSETAISG----------LQSLKILDVSYME 224
            :....|.|:|.|..|.|.||..:       :.|.|.:....|          |:...:.||...|
  Rat   196 ILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQRRTIGQFTLCMAPVHLRGFSVADVQKKE 260

  Fly   225 IDDLPDTILHGPRDLEIFIAAGNLFNQLPKALKYATN-------------------LTSLVLNEN 270
            .      :..||........|.:|  ..|.|...:.|                   :..:.|.:|
  Rat   261 Y------VCPGPHSEAPACNANSL--SCPSACSCSNNIVDCRGKGLTEIPANLPEGIVEIRLEQN 317

  Fly   271 PIENLIGDNVFPPLTKLTHLSMTFMSKLYKIGPGAFSELQSLTELILSDNK-------------- 321
            .|:: |....|....||..:.:: .:::..|.|.||..|:|||.|:|..||              
  Rat   318 SIKS-IPAGAFIQYKKLKRIDIS-KNQISDIAPDAFQGLKSLTSLVLYGNKITEIPKGLFDGLVS 380

  Fly   322 ----LLNEIDEEALSKNVTGGQYLDYPPLEKVYLNNCNVSTLPKELLVRWDKLKALDLRFNPWNC 382
                |||......|..|.    :.|...|..:.|.:..:.|:.|.|......::.|.|..||:.|
  Rat   381 LQLLLLNANKINCLRVNT----FQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVC 441

  Fly   383 DESNDFLINVLIDRINKTTPVLAKDVKCGGPNKLNDVTLLRVANE 427
            |....:|.:.|.|     .|:.....:|..|.:|.:..:.::.::
  Rat   442 DCHLKWLADYLQD-----NPIETSGARCSSPRRLANKRISQIKSK 481

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5096NP_723576.1 LRR_RI 69..378 CDD:238064 86/384 (22%)
leucine-rich repeat 85..104 CDD:275380 4/16 (25%)
LRR_8 105..174 CDD:290566 28/108 (26%)
leucine-rich repeat 105..128 CDD:275380 11/25 (44%)
leucine-rich repeat 129..163 CDD:275380 13/70 (19%)
LRR_8 163..222 CDD:290566 18/75 (24%)
leucine-rich repeat 164..187 CDD:275380 6/22 (27%)
leucine-rich repeat 188..214 CDD:275380 9/42 (21%)
leucine-rich repeat 215..238 CDD:275380 5/22 (23%)
leucine-rich repeat 239..261 CDD:275380 4/21 (19%)
LRR_8 260..322 CDD:290566 20/98 (20%)
leucine-rich repeat 262..286 CDD:275380 5/23 (22%)
leucine-rich repeat 287..311 CDD:275380 6/23 (26%)
leucine-rich repeat 346..369 CDD:275380 5/22 (23%)
leucine-rich repeat 370..388 CDD:275380 6/17 (35%)
Slit3NP_112611.1 leucine-rich repeat 311..332 CDD:275380 5/21 (24%)
LRR_4 331..371 CDD:289563 14/40 (35%)
LRR 8 332..353 6/21 (29%)
leucine-rich repeat 333..356 CDD:275380 6/23 (26%)
LRR_8 355..439 CDD:290566 21/87 (24%)
LRR 9 356..377 7/20 (35%)
leucine-rich repeat 357..377 CDD:275380 6/19 (32%)
LRR 10 380..401 5/24 (21%)
leucine-rich repeat 381..404 CDD:275380 6/26 (23%)
LRR 11 404..425 5/20 (25%)
leucine-rich repeat 405..426 CDD:275380 5/20 (25%)
TPKR_C2 437..>467 CDD:301599 9/34 (26%)
LRRNT 505..535 CDD:214470
LRR 12 533..554
leucine-rich repeat 534..558 CDD:275380
LRR_4 535..574 CDD:289563
LRR_8 557..617 CDD:290566
LRR 13 558..579
leucine-rich repeat 559..582 CDD:275380
LRR 14 582..603
leucine-rich repeat 583..606 CDD:275380
LRR_8 605..665 CDD:290566
LRR 15 606..627
leucine-rich repeat 607..630 CDD:275380
LRR 16 630..651
leucine-rich repeat 631..654 CDD:275380
leucine-rich repeat 655..745 CDD:275380
LRRCT 663..711 CDD:214507
LRRNT 725..756 CDD:214470
LRR_RI <741..869 CDD:238064
leucine-rich repeat 746..776 CDD:275380
LRR 17 753..774
LRR_8 775..835 CDD:290566
LRR 18 776..797
leucine-rich repeat 777..800 CDD:275380
LRR 19 800..821
leucine-rich repeat 801..824 CDD:275380
LRR 20 824..845
leucine-rich repeat 825..846 CDD:275380
LRRCT 857..906 CDD:214507
EGF_CA 956..994 CDD:238011
EGF_CA 998..1031 CDD:238011
EGF_CA 1035..1072 CDD:238011
EGF_CA 1074..1110 CDD:238011
EGF 1123..1153 CDD:278437
Laminin_G_2 1188..1314 CDD:280389
EGF_CA 1370..1402 CDD:238011
GHB_like 1463..1519 CDD:304424
LRRNT 33..60 CDD:279764
LRR_RI <49..220 CDD:238064 40/153 (26%)
LRR_8 61..121 CDD:290566 19/54 (35%)
LRR 1 62..83 4/16 (25%)
leucine-rich repeat 64..86 CDD:275380 4/19 (21%)
LRR 2 86..107 9/20 (45%)
leucine-rich repeat 87..110 CDD:275380 10/22 (45%)
LRR_8 109..169 CDD:290566 11/59 (19%)
LRR 3 110..131 5/20 (25%)
leucine-rich repeat 111..134 CDD:275380 6/22 (27%)
LRR 4 134..155 3/20 (15%)
leucine-rich repeat 135..158 CDD:275380 3/22 (14%)
LRR_8 157..217 CDD:290566 15/59 (25%)
LRR 5 158..179 2/20 (10%)
leucine-rich repeat 159..182 CDD:275380 3/22 (14%)
LRR 6 182..203 5/20 (25%)
leucine-rich repeat 183..206 CDD:275380 6/22 (27%)
leucine-rich repeat 207..309 CDD:275380 19/109 (17%)
LRRNT 280..311 CDD:214470 3/30 (10%)
LRR_RI <295..457 CDD:238064 39/172 (23%)
LRR 7 308..329 5/21 (24%)
LRR_8 311..367 CDD:290566 18/57 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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