DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5096 and SLIT3

DIOPT Version :9

Sequence 1:	NP_723576.1	Gene:	CG5096 / 34410	FlyBaseID:	FBgn0032235	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_001258875.2	Gene:	SLIT3 / 6586	HGNCID:	11087	Length:	1530	Species:	Homo sapiens

Alignment Length:	466	Identity:	101/466 - (21%)
Similarity:	179/466 - (38%)	Gaps:	134/466 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 CNCYIDTNLLDCSEKLQDWLSAEDWEDLTNGNVVFKTINLEHNNLTSVP--ILPKY-DVENLYLA 111
            |.|  ..|::||..|....:.|    :|..|.|   .|.||.|::.::|  ...:| .::.:.::
Human   284 CTC--SNNIVDCRGKGLMEIPA----NLPEGIV---EIRLEQNSIKAIPAGAFTQYKKLKRIDIS 339

  Fly   112 NNQIDSISVGAFQNLTELVTLDLSHNRLTSKVLVPDVFKGPFTVQ---------------DFESL 161
            .|||..|:..|||.|..|.:|.|..|::|.  :|..:|.|..::|               .|:.|
Human   340 KNQISDIAPDAFQGLKSLTSLVLYGNKITE--IVKGLFDGLVSLQLLLLNANKINCLRVNTFQDL 402

  Fly   162 ENLKTLNLGYNDLHSLDADLFEHIPHIEELVLCSNSFHVID------------------------ 202
            :||..|:|..|.|.::...||..:..|:.|.|..|.| |.|
Human   403 QNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPF-VCDCHLKWLADYLQDNPIETSGARCSS 466

  Fly   203 --QLSETAISGLQSLK--------------------------------ILDVSYMEIDDLPDTIL 233
              :|:...||.::|.|                                |:|.|..::..:|
Human   467 PRRLANKRISQIKSKKFRCSGSEDYRSRFSSECFMDLVCPEKCRCEGTIVDCSNQKLVRIP---- 527

  Fly   234 HGPRDLEIFIAAGNLFNQLPKALKYATNLTSLVLNENPIENLIGDNVFPPLTKLTHLSMTFMSKL 298
                            :.||   :|.|:|.   ||:|.:..|....:|..|..|..:::: .:|:
Human   528 ----------------SHLP---EYVTDLR---LNDNEVSVLEATGIFKKLPNLRKINLS-NNKI 569

  Fly   299 YKIGPGAFSELQSLTELILSDNKL----------LNEIDEEALSKNVTG----GQYLDYPPLEKV 349
            .::..|||....|:.||:|:.|:|          |:.:....|..|:.|    ..:.....:..:
Human   570 KEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLL 634

  Fly   350 YLNNCNVSTLPKELLVRWDKLKALDLRFNPWNCDESNDFLINVLIDRINKTTPVLAKDVKCGGPN 414
            .|.:..::|:..........|..::|..||:||:....:|...|..|     .:::.:.:|..|.
Human   635 SLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRKR-----RIVSGNPRCQKPF 694

  Fly   415 KLNDVTLLRVA 425
            .|.::.:..||
Human   695 FLKEIPIQDVA 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5096	NP_723576.1	LRR_RI	69..378	CDD:238064	83/398 (21%)
		leucine-rich repeat	85..104	CDD:275380	6/21 (29%)
		LRR_8	105..174	CDD:290566	24/83 (29%)
		leucine-rich repeat	105..128	CDD:275380	8/22 (36%)
		leucine-rich repeat	129..163	CDD:275380	11/48 (23%)
		LRR_8	163..222	CDD:290566	22/116 (19%)
		leucine-rich repeat	164..187	CDD:275380	7/22 (32%)
		leucine-rich repeat	188..214	CDD:275380	10/51 (20%)
		leucine-rich repeat	215..238	CDD:275380	5/54 (9%)
		leucine-rich repeat	239..261	CDD:275380	3/21 (14%)
		LRR_8	260..322	CDD:290566	18/61 (30%)
		leucine-rich repeat	262..286	CDD:275380	7/23 (30%)
		leucine-rich repeat	287..311	CDD:275380	5/23 (22%)
		leucine-rich repeat	346..369	CDD:275380	2/22 (9%)
		leucine-rich repeat	370..388	CDD:275380	6/17 (35%)
SLIT3	NP_001258875.2	LRRNT	33..64	CDD:214470
		LRR	<62..>220	CDD:227223
		LRR 1	62..83
		leucine-rich repeat	64..86	CDD:275380
		LRR 2	86..107
		leucine-rich repeat	87..110	CDD:275380
		internalin_A	107..>478	CDD:380193	53/205 (26%)
		LRR 3	110..131
		leucine-rich repeat	111..134	CDD:275380
		LRR 4	134..155
		leucine-rich repeat	135..158	CDD:275380
		LRR 5	158..179
		leucine-rich repeat	159..182	CDD:275380
		LRR 6	182..203
		leucine-rich repeat	183..206	CDD:275380
		leucine-rich repeat	207..308	CDD:275380	8/29 (28%)
		LRR 7	308..329		7/23 (30%)
		leucine-rich repeat	309..332	CDD:275380	7/25 (28%)
		LRR_8	311..367	CDD:338972	18/55 (33%)
		LRR 8	332..353		6/20 (30%)
		leucine-rich repeat	333..356	CDD:275380	8/22 (36%)
		LRR 9	356..377		7/22 (32%)
		leucine-rich repeat	357..377	CDD:275380	7/21 (33%)
		LRR 10	380..401		2/20 (10%)
		leucine-rich repeat	381..404	CDD:275380	3/22 (14%)
		LRR 11	404..425		8/20 (40%)
		leucine-rich repeat	405..428	CDD:275380	7/22 (32%)
		LRRNT	505..535	CDD:214470	7/52 (13%)
		LRR 12	533..554		7/23 (30%)
		LRR_8	534..593	CDD:338972	18/62 (29%)
		leucine-rich repeat	534..558	CDD:275380	8/26 (31%)
		LRR 13	558..579		5/21 (24%)
		leucine-rich repeat	559..582	CDD:275380	5/23 (22%)
		LRR_8	582..641	CDD:338972	11/58 (19%)
		LRR 14	582..603		6/20 (30%)
		leucine-rich repeat	583..606	CDD:275380	6/22 (27%)
		LRR 15	606..627		3/20 (15%)
		leucine-rich repeat	607..630	CDD:275380	3/22 (14%)
		LRR 16	630..651		2/20 (10%)
		leucine-rich repeat	631..654	CDD:275380	2/22 (9%)
		PCC	636..>714	CDD:188093	16/75 (21%)
		leucine-rich repeat	655..745	CDD:275380	14/56 (25%)
		LRRNT	725..756	CDD:214470
		LRR	<743..>869	CDD:227223
		leucine-rich repeat	746..776	CDD:275380
		LRR 17	753..775
		LRR_8	776..835	CDD:338972
		LRR 18	776..797
		leucine-rich repeat	777..800	CDD:275380
		LRR 19	800..821
		leucine-rich repeat	801..824	CDD:275380
		LRR 20	824..845
		leucine-rich repeat	825..846	CDD:275380
		PCC	830..>912	CDD:188093
		EGF_CA	963..1001	CDD:238011
		EGF_CA	1005..1038	CDD:238011
		EGF_CA	1042..1079	CDD:238011
		EGF_CA	1081..1117	CDD:238011
		EGF	1130..1160	CDD:333761
		LamG	1188..1321	CDD:214598
		EGF	1379..1407	CDD:333761
		GHB_like	<1473..1528	CDD:389804
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910