DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5096 and Slit1

DIOPT Version :9

Sequence 1:	NP_723576.1	Gene:	CG5096 / 34410	FlyBaseID:	FBgn0032235	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_075242.1	Gene:	Slit1 / 65047	RGDID:	69307	Length:	1531	Species:	Rattus norvegicus

Alignment Length:	461	Identity:	113/461 - (24%)
Similarity:	178/461 - (38%)	Gaps:	118/461 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 CNCYIDTNLLDCSEKLQDWLSAEDWEDLTNGNVVFKTINLEHNNLTSVP---ILPKYDVENLYLA 111
            |:|  ...::||..|....:.|...|.:|.       |.||.|.:.|:|   ..|...:..:.|:
  Rat   286 CSC--SNGIVDCRGKGLTAIPANLPETMTE-------IRLELNGIKSIPPGAFSPYRKLRRIDLS 341

  Fly   112 NNQIDSISVGAFQNLTELVTLDLSHNRLTSKVLVPDVFKGPFTVQ---------------DFESL 161
            ||||..|:..|||.|..|.:|.|..|::|.  |...||.|.:|:|               .|:.|
  Rat   342 NNQIAEIAPDAFQGLRSLNSLVLYGNKITD--LPRGVFGGLYTLQLLLLNANKINCIRPDAFQDL 404

  Fly   162 ENLKTLNLGYNDLHSLDADLFEHIPHIEELVLCSNSFHVID------------------------ 202
            :||..|:|..|.:.||....|..:..|:.|.|..|.| :.|
  Rat   405 QNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPF-ICDCNLKWLADFLRTNPIETTGARCAS 468

  Fly   203 --QLSETAISGLQSLKILDVSYMEIDDLPDT--------------ILHGPR-DLEIFIAAGNLFN 250
              :|:...|..::|.| ...|..|...:|.|              ..|..| :..:...:|...:
  Rat   469 PRRLANKRIGQIKSKK-FRCSAKEQYFIPGTEDYHLNSECTSDVACPHKCRCEASVVECSGLKLS 532

  Fly   251 QLPKALKYATNLTSLVLNENPIENLIGDNVFPPLTKLTHLSMTFMS--KLYKIGPGAFSELQSLT 313
            ::|:.:..:|  |.|.||.|.|..|....:|   .||:||....:|  |:.:|..|.|....|::
  Rat   533 KIPERIPQST--TELRLNNNEISILEATGLF---KKLSHLKKINLSNNKVSEIEDGTFEGATSVS 592

  Fly   314 ELILSDNKLLNEIDEEALSKNVTGGQYLDYPPLEKVYLNNCNVSTLPKE---------LLVRWDK 369
            ||.|:.|:|          ::|..|.:.....|..:.|.|..:|.:..:         ||..:|.
  Rat   593 ELHLTANQL----------ESVRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDN 647

  Fly   370 ---------------LKALDLRFNPWNCDESNDFLINVLIDRINKTTPVLAKDVKCGGPNKLNDV 419
                           |..|:|..||:||:....:|.:.|..|     .::..:.:|..|:.|..:
  Rat   648 HITTISPGAFDTLQALSTLNLLANPFNCNCQLAWLGDWLRKR-----KIVTGNPRCQNPDFLRQI 707

  Fly   420 TLLRVA 425
            .|..||
  Rat   708 PLQDVA 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5096	NP_723576.1	LRR_RI	69..378	CDD:238064	95/393 (24%)
		leucine-rich repeat	85..104	CDD:275380	7/21 (33%)
		LRR_8	105..174	CDD:290566	28/83 (34%)
		leucine-rich repeat	105..128	CDD:275380	10/22 (45%)
		leucine-rich repeat	129..163	CDD:275380	13/48 (27%)
		LRR_8	163..222	CDD:290566	18/84 (21%)
		leucine-rich repeat	164..187	CDD:275380	7/22 (32%)
		leucine-rich repeat	188..214	CDD:275380	8/51 (16%)
		leucine-rich repeat	215..238	CDD:275380	7/37 (19%)
		leucine-rich repeat	239..261	CDD:275380	2/21 (10%)
		LRR_8	260..322	CDD:290566	23/63 (37%)
		leucine-rich repeat	262..286	CDD:275380	8/23 (35%)
		leucine-rich repeat	287..311	CDD:275380	8/25 (32%)
		leucine-rich repeat	346..369	CDD:275380	6/31 (19%)
		leucine-rich repeat	370..388	CDD:275380	7/17 (41%)
Slit1	NP_075242.1	LRRNT	33..64	CDD:214470
		leucine-rich repeat	43..62	CDD:275380
		LRR_8	61..121	CDD:290566
		LRR 1	62..83
		leucine-rich repeat	63..86	CDD:275380
		LRR 2	86..107
		LRR_RI	<87..275	CDD:238064
		leucine-rich repeat	87..110	CDD:275380
		LRR_8	109..169	CDD:290566
		LRR 3	110..131
		leucine-rich repeat	111..134	CDD:275380
		LRR 4	134..155
		leucine-rich repeat	135..158	CDD:275380
		LRR 5	158..179
		LRR_8	159..217	CDD:290566
		leucine-rich repeat	159..182	CDD:275380
		LRR 6	182..203
		leucine-rich repeat	183..206	CDD:275380
		leucine-rich repeat	207..334	CDD:275380	15/56 (27%)
		LRRNT	282..313	CDD:214470	7/28 (25%)
		LRR 7	310..331		7/27 (26%)
		LRR_8	312..369	CDD:290566	22/63 (35%)
		LRR_4	334..373	CDD:289563	15/40 (38%)
		LRR 8	334..355		8/20 (40%)
		leucine-rich repeat	335..358	CDD:275380	10/22 (45%)
		LRR 9	358..379		8/22 (36%)
		leucine-rich repeat	359..379	CDD:275380	8/21 (38%)
		LRR 10	382..403		3/20 (15%)
		leucine-rich repeat	383..406	CDD:275380	3/22 (14%)
		LRR_8	389..441	CDD:290566	14/51 (27%)
		LRR_RI	<398..627	CDD:238064	57/245 (23%)
		LRR 11	406..427		8/20 (40%)
		leucine-rich repeat	407..428	CDD:275380	7/20 (35%)
		leucine-rich repeat	431..528	CDD:275380	16/98 (16%)
		leucine-rich repeat	529..566	CDD:275380	12/41 (29%)
		LRR 12	541..562		9/25 (36%)
		LRR_8	543..601	CDD:290566	22/60 (37%)
		LRR_4	543..582	CDD:289563	15/41 (37%)
		LRR 13	566..587		7/20 (35%)
		leucine-rich repeat	567..590	CDD:275380	6/22 (27%)
		LRR_8	589..649	CDD:290566	15/69 (22%)
		LRR 14	590..611		8/30 (27%)
		leucine-rich repeat	591..614	CDD:275380	7/32 (22%)
		LRR 15	614..635		4/20 (20%)
		LRR_4	615..654	CDD:289563	7/38 (18%)
		leucine-rich repeat	615..638	CDD:275380	4/22 (18%)
		LRR 16	638..659		3/20 (15%)
		leucine-rich repeat	639..660	CDD:275380	3/20 (15%)
		leucine-rich repeat	663..754	CDD:275380	16/56 (29%)
		LRRCT	671..719	CDD:214507	13/48 (27%)
		LRRNT	733..765	CDD:214470
		leucine-rich repeat	755..785	CDD:275380
		LRR_8	761..820	CDD:290566
		LRR 17	762..783
		LRR 18	785..806
		LRR_4	786..827	CDD:289563
		leucine-rich repeat	786..809	CDD:275380
		LRR 19	809..830
		leucine-rich repeat	810..830	CDD:275380
		LRR 20	833..854
		leucine-rich repeat	834..857	CDD:275380
		LRRCT	866..915	CDD:214507
		EGF_CA	927..962	CDD:238011
		EGF_CA	966..1002	CDD:238011
EGF_CA	1005..1041	CDD:238011
EGF_CA	1044..1080	CDD:238011
EGF_CA	1085..1119	CDD:238011
LamG	1186..1319	CDD:214598
GHB_like	<1494..1529	CDD:304424
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910