DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5096 and lrrc4.2

DIOPT Version :9

Sequence 1:	NP_723576.1	Gene:	CG5096 / 34410	FlyBaseID:	FBgn0032235	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_001093494.1	Gene:	lrrc4.2 / 566572	ZFINID:	ZDB-GENE-030131-7997	Length:	644	Species:	Danio rerio

Alignment Length:	387	Identity:	92/387 - (23%)
Similarity:	143/387 - (36%)	Gaps:	110/387 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SATLAAAIFCIVLS-QVSGQTKDETTTTETPKEKIKVIDSKLCKKCNCYIDTNLLDCSE----KL 65
            :|.|..|::.:|.| .||.....:.|....               |.|...:|.:.|:.    ::
Zfish    14 NAALLCAVYLMVRSWSVSAAPSGQLTCPSV---------------CFCSNVSNKVVCTRRSLVRV 63

  Fly    66 QDWLSAEDWEDLTNGNVVFKTINLEHNNLTSV---PILPKYDVENLYLANNQIDSISVGAFQNLT 127
            ...:.|           ..:.:||..|::.::   .......:|.|.|..|.|..|.||||..|.
Zfish    64 PPGIPA-----------TTRHLNLMENSIETIEAGTFQHLRHLEVLQLGRNSIRQIEVGAFSGLN 117

  Fly   128 ELVTLDLSHNRLTSKVLVPDVFKGPFTVQDFESLENLKTLNLGYNDLHSLDADLFEHIPHIEELV 192
            .|.||:|..||||   ::|.        ..||.|..|:.|.|..|.:.|:.:..|..:|.:..|.
Zfish   118 SLNTLELFDNRLT---VIPS--------GAFEYLSKLRELWLRSNPIESIPSYAFNRVPSLMRLD 171

  Fly   193 LCSNSFHVIDQLSETAISGLQSLKILDVSYMEIDDLPD-TILHGPRDLEIFIAAGNLFNQLPKAL 256
            |  .....::.:||.|..||.:||.|::....:.::|. |.|.|..:||
Zfish   172 L--GELRKLEYISEGAFEGLHNLKYLNLGMCNLREMPVLTPLVGLEELE---------------- 218

  Fly   257 KYATNLTSLVLNENPIENLIGDNVFPPLTKLTHLSMTFMSKLYKIGPGAFSELQSLTELILSDNK 321
                               :.:|.||.|.                 ||:|..|:||.:|.:. |.
Zfish   219 -------------------MSENYFPELK-----------------PGSFRGLKSLKKLWIM-NS 246

  Fly   322 LLNEIDEEALSKNVTGGQYLDYPPLEKVYLNNCNVSTLPKELLVRWDKLKALDLRFNPWNCD 383
            .:..|:..|..         |...|.::.|.:.|:|:||.:|......|..|.|..|||.||
Zfish   247 RITTIERNAFD---------DVTALVELNLAHNNLSSLPHDLFAPLSYLVELHLHHNPWRCD 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5096	NP_723576.1	LRR_RI	69..378	CDD:238064	75/312 (24%)
		leucine-rich repeat	85..104	CDD:275380	3/21 (14%)
		LRR_8	105..174	CDD:290566	27/68 (40%)
		leucine-rich repeat	105..128	CDD:275380	11/22 (50%)
		leucine-rich repeat	129..163	CDD:275380	12/33 (36%)
		LRR_8	163..222	CDD:290566	17/58 (29%)
		leucine-rich repeat	164..187	CDD:275380	6/22 (27%)
		leucine-rich repeat	188..214	CDD:275380	7/25 (28%)
		leucine-rich repeat	215..238	CDD:275380	7/23 (30%)
		leucine-rich repeat	239..261	CDD:275380	2/21 (10%)
		LRR_8	260..322	CDD:290566	12/61 (20%)
		leucine-rich repeat	262..286	CDD:275380	4/23 (17%)
		leucine-rich repeat	287..311	CDD:275380	4/23 (17%)
		leucine-rich repeat	346..369	CDD:275380	7/22 (32%)
		leucine-rich repeat	370..388	CDD:275380	8/14 (57%)
lrrc4.2	NP_001093494.1	leucine-rich repeat	71..94	CDD:275380	3/22 (14%)
		LRR_8	72..129	CDD:290566	19/56 (34%)
		LRR_RI	74..>276	CDD:238064	68/276 (25%)
		leucine-rich repeat	95..118	CDD:275380	11/22 (50%)
		leucine-rich repeat	119..142	CDD:275380	12/33 (36%)
		LRR_8	141..202	CDD:290566	17/62 (27%)
		leucine-rich repeat	143..166	CDD:275380	6/22 (27%)
		leucine-rich repeat	167..191	CDD:275380	7/25 (28%)
		leucine-rich repeat	192..213	CDD:275380	6/20 (30%)
		LRR_8	213..272	CDD:290566	20/120 (17%)
		leucine-rich repeat	214..237	CDD:275380	10/74 (14%)
		leucine-rich repeat	238..261	CDD:275380	6/32 (19%)
		leucine-rich repeat	262..283	CDD:275380	7/20 (35%)
		LRRCT	294..345	CDD:214507	5/6 (83%)
		IG_like	353..435	CDD:214653
		Ig	365..435	CDD:299845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910