DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5096 and lingo2b

DIOPT Version :9

Sequence 1:	NP_723576.1	Gene:	CG5096 / 34410	FlyBaseID:	FBgn0032235	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_001139054.1	Gene:	lingo2b / 564052	ZFINID:	ZDB-GENE-080723-57	Length:	607	Species:	Danio rerio

Alignment Length:	393	Identity:	88/393 - (22%)
Similarity:	149/393 - (37%)	Gaps:	93/393 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 IDTNLLDCSEKLQDWLSAEDWEDLTNGNVVFKTINLEHNNLTSVP-----ILPKYDVENLYLANN 113
            |:|..||.|:.....::.:::..|    ::.:.::|.:|.|:||.     ..|:  :.:|.|.:|
Zfish    56 IETRSLDLSKNRLRIVTPQNFSSL----LLLEELDLSNNLLSSVEPNSFRAQPR--LRSLRLRSN 114

  Fly   114 QIDSISVGAFQNLTELVTLDLSHNRLTSKVLVPDVFKGPFTVQDFESLENLKTLNLGYNDLHSLD 178
            |:..:..||...|:||..||:|.|||   |::.|        ..||....|:.|.|..|:|..:.
Zfish   115 QLTLLPRGALAGLSELTLLDVSQNRL---VILLD--------YGFEEQRRLRVLELSDNELVFIA 168

  Fly   179 ADLFEHIPHIEELVLCSNSFHVIDQLSETAISGLQSLKILDVSYMEIDDLPDTILHGPRDLEIFI 243
            ...|..:..:..|.|...:...:...:...:.||.||::.|:...|:.  ..|....||...:.:
Zfish   169 PRAFSGLASLRSLTLQRCNLSTVPTHALAHLHGLTSLRLRDLGIAELQ--AHTFKGLPRLKHLEV 231

  Fly   244 AAGNLFNQLPKALKYATNLTSLVLNENPIENLIGDNVFPPLTKLTHLSMTF-------------- 294
            ....|....|.:.....||::|.:...   ||....|...|..||||::::
Zfish   232 DRWPLLEGFPTSALQGLNLSTLSITHT---NLTSVPVVTNLLYLTHLNLSYSRIRVLPAGWLRGM 293

  Fly   295 ---------MSKLYKIGPGAFSELQSLTELILSDNKLLNEIDEEALSKNVTGGQYLDYPPLEKVY 350
                     .:.|..:.|.||....||..|.|..|:|
Zfish   294 DRLEVLRVRQANLLSVEPQAFQGASSLRILDLCYNRL---------------------------- 330

  Fly   351 LNNCNVSTLPKELLVRWDKLKALDLRFNPWNCDESNDFLINVLIDRINKTTPVLAKDV--KCGGP 413
                  :||.:.:....:.|:.|.:..||..||....:|       :.:|.|:|..||  :|..|
Zfish   331 ------ATLERSVFPVTEALQTLLIGQNPLVCDCRLRWL-------LERTPPLLYGDVQPECSAP 382

  Fly   414 NKL 416
            ..|
Zfish   383 APL 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5096	NP_723576.1	LRR_RI	69..378	CDD:238064	70/336 (21%)
		leucine-rich repeat	85..104	CDD:275380	6/23 (26%)
		LRR_8	105..174	CDD:290566	23/68 (34%)
		leucine-rich repeat	105..128	CDD:275380	7/22 (32%)
		leucine-rich repeat	129..163	CDD:275380	11/33 (33%)
		LRR_8	163..222	CDD:290566	13/58 (22%)
		leucine-rich repeat	164..187	CDD:275380	6/22 (27%)
		leucine-rich repeat	188..214	CDD:275380	4/25 (16%)
		leucine-rich repeat	215..238	CDD:275380	5/22 (23%)
		leucine-rich repeat	239..261	CDD:275380	2/21 (10%)
		LRR_8	260..322	CDD:290566	20/84 (24%)
		leucine-rich repeat	262..286	CDD:275380	6/23 (26%)
		leucine-rich repeat	287..311	CDD:275380	8/46 (17%)
		leucine-rich repeat	346..369	CDD:275380	2/22 (9%)
		leucine-rich repeat	370..388	CDD:275380	6/17 (35%)
lingo2b	NP_001139054.1	LRRNT	26..58	CDD:214470	1/1 (100%)
		leucine-rich repeat	37..60	CDD:275380	2/3 (67%)
		LRR_8	59..116	CDD:290566	13/62 (21%)
		leucine-rich repeat	61..81	CDD:275380	4/23 (17%)
		LRR_RI	<103..214	CDD:238064	33/123 (27%)
		LRR_8	104..188	CDD:290566	28/96 (29%)
		leucine-rich repeat	106..129	CDD:275380	7/22 (32%)
		leucine-rich repeat	130..153	CDD:275380	11/33 (33%)
		leucine-rich repeat	154..177	CDD:275380	6/22 (27%)
		leucine-rich repeat	178..201	CDD:275380	2/22 (9%)
		LRR_8	201..260	CDD:290566	14/63 (22%)
		leucine-rich repeat	202..225	CDD:275380	6/24 (25%)
		leucine-rich repeat	226..271	CDD:275380	9/47 (19%)
		LRR_8	272..330	CDD:290566	13/57 (23%)
		leucine-rich repeat	272..295	CDD:275380	4/22 (18%)
		leucine-rich repeat	296..319	CDD:275380	4/22 (18%)
		leucine-rich repeat	320..338	CDD:275380	7/51 (14%)
		leucine-rich repeat	344..356	CDD:275378	4/11 (36%)
		LRRCT	352..394	CDD:214507	13/41 (32%)
		IG_like	419..497	CDD:214653
		Ig	422..497	CDD:299845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910