DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5096 and Tollo

DIOPT Version :9

Sequence 1:	NP_723576.1	Gene:	CG5096 / 34410	FlyBaseID:	FBgn0032235	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster

Alignment Length:	361	Identity:	93/361 - (25%)
Similarity:	155/361 - (42%)	Gaps:	62/361 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 LDCSEKLQDWLSAEDWEDLTNGNVVFKTINLEHNNLTSVPILPKY-----DVENLYLANNQIDSI 118
            |:.::....:|:...:|.|.:    .:.::|..|.|||:|  |:.     .::.:||.||.|:.:
  Fly   239 LNMAKNSMSFLADRAFEGLLS----LRVVDLSANRLTSLP--PELFAETKQLQEIYLRNNSINVL 297

  Fly   119 SVGAFQNLTELVTLDLSHNRLTSKVLVPDVFKG---------------PFTVQDFESLENLKTLN 168
            :.|.|..|.||:.|||:.|.|.|:.:....|.|               ......|..|.:|:.|.
  Fly   298 APGIFGELAELLVLDLASNELNSQWINAATFVGLKRLMMLDLSANKISRLEAHIFRPLASLQILK 362

  Fly   169 LGYNDLHSLDADLFEHIPHIEELVLCSNSFHVIDQLSETAISGLQSLKILDVSYMEIDDLPDTIL 233
            |..|.:..|...:|..:.::..|:|..|...||:|   ..:.||::|.:|.:.:..|..:....|
  Fly   363 LEDNYIDQLPGGIFADLTNLHTLILSRNRISVIEQ---RTLQGLKNLLVLSLDFNRISRMDQRSL 424

  Fly   234 HGPRDLEIFIAAGNLFNQLPKALKYATNLTSLVLNENPIENLIGDNVFPPLTKLTHLSMTFMSKL 298
            .....|:......|....:|:||.:...|.:|.:.||.|..:...:: ..|..|..|.|| .:.|
  Fly   425 VNCSQLQDLHLNDNKLQAVPEALAHVQLLKTLDVGENMISQIENTSI-TQLESLYGLRMT-ENSL 487

  Fly   299 YKIGPGAFSELQSLTELILSDNKLLNEIDEEALSKN-------VTGGQ-------YLDYPPLEKV 349
            ..|..|.|..:.||..|.||.|| |..|:..:|.:|       :.|.|       :.:.|.|  |
  Fly   488 THIRRGVFDRMSSLQILNLSQNK-LKSIEAGSLQRNSQLQAIRLDGNQLKSIAGLFTELPNL--V 549

  Fly   350 YLN-------NCNVSTLPKELLVRWDKLKALDLRFN 378
            :||       ..:.|.:|  :.::|     ||:|.|
  Fly   550 WLNISGNRLEKFDYSHIP--IGLQW-----LDVRAN 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5096	NP_723576.1	LRR_RI	69..378	CDD:238064	91/349 (26%)
		leucine-rich repeat	85..104	CDD:275380	7/23 (30%)
		LRR_8	105..174	CDD:290566	24/83 (29%)
		leucine-rich repeat	105..128	CDD:275380	8/22 (36%)
		leucine-rich repeat	129..163	CDD:275380	11/48 (23%)
		LRR_8	163..222	CDD:290566	16/58 (28%)
		leucine-rich repeat	164..187	CDD:275380	6/22 (27%)
		leucine-rich repeat	188..214	CDD:275380	8/25 (32%)
		leucine-rich repeat	215..238	CDD:275380	4/22 (18%)
		leucine-rich repeat	239..261	CDD:275380	5/21 (24%)
		LRR_8	260..322	CDD:290566	20/61 (33%)
		leucine-rich repeat	262..286	CDD:275380	6/23 (26%)
		leucine-rich repeat	287..311	CDD:275380	8/23 (35%)
		leucine-rich repeat	346..369	CDD:275380	7/29 (24%)
		leucine-rich repeat	370..388	CDD:275380	4/9 (44%)
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064	11/47 (23%)
		leucine-rich repeat	100..123	CDD:275380
		leucine-rich repeat	124..144	CDD:275380
		LRR_8	152..222	CDD:290566
		leucine-rich repeat	154..177	CDD:275380
		leucine-rich repeat	178..201	CDD:275380
		LRR	210..656	CDD:227223	93/361 (26%)
		leucine-rich repeat	212..235	CDD:275380
		leucine-rich repeat	236..259	CDD:275380	4/19 (21%)
		leucine-rich repeat	260..283	CDD:275380	7/24 (29%)
		LRR_RI	276..558	CDD:238064	75/289 (26%)
		leucine-rich repeat	284..307	CDD:275380	8/22 (36%)
		leucine-rich repeat	308..333	CDD:275380	9/24 (38%)
		leucine-rich repeat	334..357	CDD:275380	2/22 (9%)
		leucine-rich repeat	358..381	CDD:275380	6/22 (27%)
		leucine-rich repeat	382..405	CDD:275380	8/25 (32%)
		leucine-rich repeat	406..429	CDD:275380	4/22 (18%)
		leucine-rich repeat	430..452	CDD:275380	5/21 (24%)
		leucine-rich repeat	453..500	CDD:275380	14/48 (29%)
		leucine-rich repeat	501..521	CDD:275380	9/20 (45%)
		leucine-rich repeat	525..547	CDD:275380	2/21 (10%)
		leucine-rich repeat	548..573	CDD:275380	7/33 (21%)
		leucine-rich repeat	604..640	CDD:275380
		leucine-rich repeat	641..688	CDD:275380
		leucine-rich repeat	689..816	CDD:275380
		LRR_8	815..875	CDD:290566
		leucine-rich repeat	817..864	CDD:275380
		LRR_8	864..921	CDD:290566
		leucine-rich repeat	865..888	CDD:275380
		leucine-rich repeat	889..910	CDD:275380
		TIR	1076..1211	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010