DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5096 and CG4781

DIOPT Version :9

Sequence 1:	NP_723576.1	Gene:	CG5096 / 34410	FlyBaseID:	FBgn0032235	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_611951.1	Gene:	CG4781 / 37943	FlyBaseID:	FBgn0035043	Length:	469	Species:	Drosophila melanogaster

Alignment Length:	494	Identity:	113/494 - (22%)
Similarity:	202/494 - (40%)	Gaps:	120/494 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 KIKVIDSKLCKKCNCYIDTN-----LLDCSEKLQDWLSAEDWEDLTNGN------VVFKTINLEH 91
            :.:|||::...:. ||.:::     ..:||.     :||..|     ||      ..:|...:..
  Fly    26 RAEVIDAEETDRF-CYPESSKNSRRSCECSN-----VSASPW-----GNRALRIDCSYKDYKVAD 79

  Fly    92 NNLTSVPILPKYDVENLYLANNQIDSISVGAFQNLTELVTLDLSHNRLTSKVLVPDVFKGPFTVQ 156
            .:|    :||.| :::|.|:.|.:||:.:....:|.:   |:|.||.::..|      .|
  Fly    80 LSL----LLPLY-IDSLDLSWNALDSVPIFTSDSLHQ---LNLRHNNISQLV------SG----- 125

  Fly   157 DFESLENLKTLNLGYNDLHSLDADLFEHIPHIEELVLCSNSFHVIDQLSETAISGLQSLKILDVS 221
            :|:.|.:|:.|.||:|.:..|::..|:.:||::.|.|..|:.|:   |.....:.|..|..||:|
  Fly   126 NFKQLTSLRELYLGWNSIGKLESGSFDGLPHLQVLDLAHNNLHL---LPGHLFAPLLVLGTLDIS 187

  Fly   222 Y-----------------------MEIDDLPDTILHGP-----RDLEIFIAAGNLFNQLPKALKY 258
            :                       :.:|......||.|     ::|.:   ..|...::|..|
  Fly   188 WNRRFNESGGDLYTGLGVNWKLSTLRLDACSLNDLHLPVNAPLKELSL---RRNQLKRIPTQL-- 247

  Fly   259 ATNLTSLVLNENPIENLIGDNVFPPLTKLTHLSMTFMSKLYKIGPGAFSELQSLTELILSDNKLL 323
            ...|..|.:::|.:|.|:.::. ..||::..|.:..|..|.::...:.:.:..|..|...:::.|
  Fly   248 PETLLRLDISDNLLEELLPEDT-ANLTQVRQLFIEDMPVLQRVVANSLTHVDVLETLSFQNSRQL 311

  Fly   324 NEIDEEALSKNVTGGQYLDYPPLEKVYLNNCN-----VSTLPKELLVRWDKLKALDLRFNPWNCD 383
            :.:|.||....:|       .|.:|..|.:.:     :.|....|...:.:|..|||...|..||
  Fly   312 SHLDAEAFGPIMT-------TPTKKRALRSLSFRGTMLRTFNSTLAPIFTQLAELDLNGLPLQCD 369

  Fly   384 ESNDFLINVLIDRINKTTPVLAKDVKCGGPNKLNDVTLLRVANEHMIESSTGSLI-------WV- 440
            ....:|         |..||.... :|..|.::..:         ::.|:.|...       |.
  Fly   370 CELVWL---------KQLPVQTNG-RCYKPARIRGM---------LVTSARGDAFSCDTWPRWAY 415

  Fly   441 GLLVVLLIAVPTIIGAY--VMKRRGCFGVFRRHDSGASS 477
            ||:|:.|||: :..|.|  ||..|...||..|...||.|
  Fly   416 GLVVLSLIAL-SAAGIYLIVMGLRPHRGVTMRRKVGAGS 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5096	NP_723576.1	LRR_RI	69..378	CDD:238064	77/347 (22%)
		leucine-rich repeat	85..104	CDD:275380	4/18 (22%)
		LRR_8	105..174	CDD:290566	19/68 (28%)
		leucine-rich repeat	105..128	CDD:275380	6/22 (27%)
		leucine-rich repeat	129..163	CDD:275380	8/33 (24%)
		LRR_8	163..222	CDD:290566	18/58 (31%)
		leucine-rich repeat	164..187	CDD:275380	7/22 (32%)
		leucine-rich repeat	188..214	CDD:275380	6/25 (24%)
		leucine-rich repeat	215..238	CDD:275380	8/50 (16%)
		leucine-rich repeat	239..261	CDD:275380	4/21 (19%)
		LRR_8	260..322	CDD:290566	12/61 (20%)
		leucine-rich repeat	262..286	CDD:275380	6/23 (26%)
		leucine-rich repeat	287..311	CDD:275380	3/23 (13%)
		leucine-rich repeat	346..369	CDD:275380	4/27 (15%)
		leucine-rich repeat	370..388	CDD:275380	7/17 (41%)
CG4781	NP_611951.1	leucine-rich repeat	90..108	CDD:275380	5/17 (29%)
		LRR_8	108..167	CDD:290566	21/72 (29%)
		leucine-rich repeat	109..132	CDD:275380	9/36 (25%)
		LRR_RI	<121..>261	CDD:238064	34/158 (22%)
		leucine-rich repeat	133..156	CDD:275380	7/22 (32%)
		leucine-rich repeat	157..180	CDD:275380	6/25 (24%)
		leucine-rich repeat	181..208	CDD:275380	4/26 (15%)
		leucine-rich repeat	230..253	CDD:275380	5/27 (19%)
		leucine-rich repeat	254..274	CDD:275380	5/20 (25%)
		leucine-rich repeat	275..299	CDD:275380	3/23 (13%)
		leucine-rich repeat	300..319	CDD:275380	5/18 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28173
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.020