DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5096 and 18w

DIOPT Version :9

Sequence 1:	NP_723576.1	Gene:	CG5096 / 34410	FlyBaseID:	FBgn0032235	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_476814.1	Gene:	18w / 37277	FlyBaseID:	FBgn0004364	Length:	1385	Species:	Drosophila melanogaster

Alignment Length:	455	Identity:	109/455 - (23%)
Similarity:	176/455 - (38%)	Gaps:	110/455 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 LTNGNVVF---KTINLEHNNLTSVPILPKYDVENLYLANNQIDSISVGAFQNLTELVTLDLSHNR 138
            |.:.|.|:   ||:.|...:...:.     ::..|:|.:|.|..:..|.:.::..|..|:|:.||
  Fly   121 LESHNAVWGPGKTLELHGQSFQGLK-----ELSELHLGDNNIRQLPEGVWCSMPSLQLLNLTQNR 180

  Fly   139 LTSKVLVPDVFKGPFTVQDFESLEN--------LKTLNLGYNDLHSL-DADLFEHIPHIEELVLC 194
            :.|...:.  |..........|..|        |:||::.:|:|.|| ||.....:..::.|.|.
  Fly   181 IRSAEFLG--FSEKLCAGSALSNANGAVSGGSELQTLDVSFNELRSLPDAWGASRLRRLQTLSLQ 243

  Fly   195 SNSFHVIDQLSETAISGLQSLKILDVSYMEIDDLPDTILHGPRDLEIFIAAGNLFNQLPKALKY- 258
            .|:   |..|:..|::||.||::|::||..:..||.....|.::|......||...:|||.|.:
  Fly   244 HNN---ISTLAPNALAGLSSLRVLNISYNHLVSLPSEAFAGNKELRELHLQGNDLYELPKGLLHR 305

  Fly   259 ----------ATNLTS--------------LVLN-ENPIENLIGDNVFPPLTKLTHLSMTFMSKL 298
                      ...|||              :||| .|.....||...|..|..|..|.|. .:.:
  Fly   306 LEQLLVLDLSGNQLTSHHVDNSTFAGLIRLIVLNLSNNALTRIGSKTFKELYFLQILDMR-NNSI 369

  Fly   299 YKIGPGAFSELQSLTELILSDNKLLNEIDEEALSKNVTGGQYLDYPPLEKVYLNNCNVSTLPKEL 363
            ..|..|||..|.:|..|.|::|:|      ..|...:..|.|:    |.|:.|||..||.:..:.
  Fly   370 GHIEEGAFLPLYNLHTLNLAENRL------HTLDNRIFNGLYV----LTKLTLNNNLVSIVESQA 424

  Fly   364 LVRWDKLKALDLRFNPWN----------------------CDESNDFLINV-------LID-RIN 398
            ......||.|||..|...                      .:..|:...|:       ||| ||.
  Fly   425 FRNCSDLKELDLSSNQLTEVPEAVQDLSMLKTLDLGENQISEFKNNTFRNLNQLTGLRLIDNRIG 489

  Fly   399 KTTPVLAKD----------------VKCGGPNKLNDVTLLRVANEHM-----IESSTGSLIWVGL 442
            ..|..:.:|                ::.|..:|..::..:|:....:     |.::..||:|:.|
  Fly   490 NITVGMFQDLPRLSVLNLAKNRIQSIERGAFDKNTEIEAIRLDKNFLTDINGIFATLASLLWLNL 554

Fly 443 442
Fly 555 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5096	NP_723576.1	LRR_RI	69..378	CDD:238064	91/338 (27%)
		leucine-rich repeat	85..104	CDD:275380	3/18 (17%)
		LRR_8	105..174	CDD:290566	18/76 (24%)
		leucine-rich repeat	105..128	CDD:275380	5/22 (23%)
		leucine-rich repeat	129..163	CDD:275380	8/33 (24%)
		LRR_8	163..222	CDD:290566	21/67 (31%)
		leucine-rich repeat	164..187	CDD:275380	9/23 (39%)
		leucine-rich repeat	188..214	CDD:275380	8/25 (32%)
		leucine-rich repeat	215..238	CDD:275380	7/22 (32%)
		leucine-rich repeat	239..261	CDD:275380	7/32 (22%)
		LRR_8	260..322	CDD:290566	23/76 (30%)
		leucine-rich repeat	262..286	CDD:275380	11/38 (29%)
		leucine-rich repeat	287..311	CDD:275380	8/23 (35%)
		leucine-rich repeat	346..369	CDD:275380	7/22 (32%)
		leucine-rich repeat	370..388	CDD:275380	7/39 (18%)
18w	NP_476814.1	leucine-rich repeat	66..91	CDD:275380
		leucine-rich repeat	92..115	CDD:275380
		LRR_8	115..181	CDD:290566	15/64 (23%)
		leucine-rich repeat	116..146	CDD:275380	6/29 (21%)
		leucine-rich repeat	147..170	CDD:275380	5/22 (23%)
		leucine-rich repeat	171..201	CDD:275380	7/31 (23%)
		LRR_RI	210..464	CDD:238064	72/267 (27%)
		leucine-rich repeat	212..236	CDD:275380	9/23 (39%)
		LRR_8	235..295	CDD:290566	19/62 (31%)
		leucine-rich repeat	237..260	CDD:275380	8/25 (32%)
		leucine-rich repeat	261..284	CDD:275380	7/22 (32%)
		LRR_8	283..345	CDD:290566	14/61 (23%)
		leucine-rich repeat	285..308	CDD:275380	7/22 (32%)
		leucine-rich repeat	309..334	CDD:275380	3/24 (13%)
		LRR_8	334..393	CDD:290566	20/59 (34%)
		leucine-rich repeat	335..358	CDD:275380	8/22 (36%)
		leucine-rich repeat	359..382	CDD:275380	8/23 (35%)
		LRR_8	382..441	CDD:290566	21/68 (31%)
		leucine-rich repeat	383..406	CDD:275380	7/28 (25%)
		leucine-rich repeat	407..430	CDD:275380	7/22 (32%)
		LRR_8	431..488	CDD:290566	11/56 (20%)
		leucine-rich repeat	431..451	CDD:275380	6/19 (32%)
		leucine-rich repeat	454..477	CDD:275380	2/22 (9%)
		LRR_8	477..559	CDD:290566	15/78 (19%)
		leucine-rich repeat	478..499	CDD:275380	6/20 (30%)
		leucine-rich repeat	502..525	CDD:275380	2/22 (9%)
		leucine-rich repeat	526..548	CDD:275380	2/21 (10%)
		leucine-rich repeat	590..617	CDD:275380
		leucine-rich repeat	618..641	CDD:275380
		leucine-rich repeat	642..689	CDD:275380
		LRRCT	679..736	CDD:214507
		leucine-rich repeat	775..796	CDD:275380
		LRR_8	797..852	CDD:290566
		leucine-rich repeat	797..817	CDD:275380
		leucine-rich repeat	818..841	CDD:275380
		LRR_8	841..900	CDD:290566
		leucine-rich repeat	842..865	CDD:275380
		LRR_4	866..907	CDD:289563
		leucine-rich repeat	866..889	CDD:275380
		leucine-rich repeat	890..911	CDD:275380
		TIR	1045..1183	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010