DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5096 and sli

DIOPT Version :9

Sequence 1:	NP_723576.1	Gene:	CG5096 / 34410	FlyBaseID:	FBgn0032235	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_001261017.1	Gene:	sli / 36746	FlyBaseID:	FBgn0264089	Length:	2157	Species:	Drosophila melanogaster

Alignment Length:	520	Identity:	121/520 - (23%)
Similarity:	191/520 - (36%)	Gaps:	142/520 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KSAT-LAAAIFCIVLSQVSGQT---------KDETTTTETPKEKIKVIDSKLCKKCN-----CYI 54
            :||| ||....|...||:.||.         |....|...|.|         |...|     |..
  Fly   270 RSATRLAPYTRCQSPSQLKGQNVADLHDQEFKCSGLTEHAPME---------CGAENSCPHPCRC 325

  Fly    55 DTNLLDCSEKLQDWLSAEDWEDLTNGNVVFKTINLEHNNLTSVPILPK-----YDVENLYLANNQ 114
            ...::||.||....:.....:|.|.       :.||.|.:|.:|  ||     ..:..:.|:||.
  Fly   326 ADGIVDCREKSLTSVPVTLPDDTTE-------LRLEQNFITELP--PKSFSSFRRLRRIDLSNNN 381

  Fly   115 IDSISVGAFQNLTELVTLDLSHNRLTSKVLVPDVFKGPFTVQ---------------DFESLENL 164
            |..|:..|...|.:|.||.|..|::  |.|...||||..::|               .|..|.:|
  Fly   382 ISRIAHDALSGLKQLTTLVLYGNKI--KDLPSGVFKGLGSLQLLLLNANEISCIRKDAFRDLHSL 444

  Fly   165 KTLNLGYNDLHSLDADLFEHIPHIEELVLCSNSF-------HVIDQLSETAI--SG--------- 211
            ..|:|..|::.||....|:.:..|:.:.|..|.|       .:.|.|.:..|  ||
  Fly   445 SLLSLYDNNIQSLANGTFDAMKSIKTVHLAKNPFICDCNLRWLADYLHKNPIETSGARCESPKRM 509

  Fly   212 ----LQSLK--ILDVSYMEI-----------DDLP----------DTILHG----PRDLEIFIAA 245
                ::||:  ....|:.|:           .|.|          |....|    |||:.:
  Fly   510 HRRRIESLREEKFKCSWDELRMKLSGECRMDSDCPAMCHCEGTTVDCTGRGLKEIPRDIPL---- 570

  Fly   246 GNLFNQLPKALKYATNLTSLVLNENPIENLIGDNVFPPLTKLTHLSMTFMSKLYKIGPGAFSELQ 310
                           :.|.|:||:|.:..:..|.:|..|..|..|.:. .::|..|.|.||....
  Fly   571 ---------------HTTELLLNDNELGRISSDGLFGRLPHLVKLELK-RNQLTGIEPNAFEGAS 619

  Fly   311 SLTELILSDNKLLNEIDEEALSKNVTGGQYLDYPPLEKVYLNNCNVSTLPKELLVRWDKLKALDL 375
            .:.||.|.:||:          |.::...:|....|:.:.|.:..:|.:........:.|.:|:|
  Fly   620 HIQELQLGENKI----------KEISNKMFLGLHQLKTLNLYDNQISCVMPGSFEHLNSLTSLNL 674

  Fly   376 RFNPWNCDESNDFLINVLIDRINKTTPVLAKDVKCGGPNKLNDVTLLRVANEHM---IESSTGSL 437
            ..||:||:....:....|     :...:.....:||.|:|:.||.:..:.:...   .|:|.|.|
  Fly   675 ASNPFNCNCHLAWFAEWL-----RKKSLNGGAARCGAPSKVRDVQIKDLPHSEFKCSSENSEGCL 734

Fly 438 437
Fly 735 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5096	NP_723576.1	LRR_RI	69..378	CDD:238064	85/377 (23%)
		leucine-rich repeat	85..104	CDD:275380	7/23 (30%)
		LRR_8	105..174	CDD:290566	25/83 (30%)
		leucine-rich repeat	105..128	CDD:275380	7/22 (32%)
		leucine-rich repeat	129..163	CDD:275380	14/48 (29%)
		LRR_8	163..222	CDD:290566	18/82 (22%)
		leucine-rich repeat	164..187	CDD:275380	7/22 (32%)
		leucine-rich repeat	188..214	CDD:275380	9/47 (19%)
		leucine-rich repeat	215..238	CDD:275380	8/49 (16%)
		leucine-rich repeat	239..261	CDD:275380	0/21 (0%)
		LRR_8	260..322	CDD:290566	19/61 (31%)
		leucine-rich repeat	262..286	CDD:275380	8/23 (35%)
		leucine-rich repeat	287..311	CDD:275380	7/23 (30%)
		leucine-rich repeat	346..369	CDD:275380	3/22 (14%)
		leucine-rich repeat	370..388	CDD:275380	7/17 (41%)
sli	NP_001261017.1	LRRNT	73..103	CDD:214470
		leucine-rich repeat	83..104	CDD:275380
		LRR_8	102..160	CDD:290566
		leucine-rich repeat	105..125	CDD:275380
		LRR_RI	<119..259	CDD:238064
		leucine-rich repeat	126..149	CDD:275380
		LRR_8	149..208	CDD:290566
		leucine-rich repeat	150..173	CDD:275380
		leucine-rich repeat	174..197	CDD:275380
		LRR_8	197..256	CDD:290566
		leucine-rich repeat	198..221	CDD:275380
		leucine-rich repeat	222..245	CDD:275380
		leucine-rich repeat	246..371	CDD:275380	30/118 (25%)
		LRRCT	254..303	CDD:214507	11/32 (34%)
		LRRNT	319..350	CDD:214470	6/30 (20%)
		LRR_8	349..406	CDD:290566	20/65 (31%)
		LRR_4	371..411	CDD:289563	14/41 (34%)
		leucine-rich repeat	372..395	CDD:275380	7/22 (32%)
		leucine-rich repeat	396..415	CDD:275380	8/20 (40%)
		leucine-rich repeat	420..443	CDD:275380	3/22 (14%)
		leucine-rich repeat	444..465	CDD:275380	7/20 (35%)
		leucine-rich repeat	468..480	CDD:275378	4/11 (36%)
		LRRCT	476..525	CDD:214507	9/48 (19%)
		leucine-rich repeat	484..545	CDD:275380	10/60 (17%)
		LRRNT	542..574	CDD:214470	7/50 (14%)
		leucine-rich repeat	552..570	CDD:275380	5/17 (29%)
		leucine-rich repeat	572..596	CDD:275380	8/23 (35%)
		LRR_RI	<574..>678	CDD:238064	27/114 (24%)
		LRR_8	595..655	CDD:290566	16/70 (23%)
		leucine-rich repeat	597..620	CDD:275380	7/23 (30%)
		leucine-rich repeat	621..644	CDD:275380	7/32 (22%)
		leucine-rich repeat	645..668	CDD:275380	3/22 (14%)
		leucine-rich repeat	669..756	CDD:275380	18/71 (25%)
		LRRCT	677..726	CDD:214507	11/53 (21%)
		LRRNT	739..770	CDD:214470
		leucine-rich repeat	757..791	CDD:275380
		LRR_4	770..807	CDD:289563
		LRR_8	790..850	CDD:290566
		LRR_4	791..830	CDD:289563
		leucine-rich repeat	792..815	CDD:275380
		LRR_4	814..863	CDD:289563
		leucine-rich repeat	816..839	CDD:275380
		leucine-rich repeat	840..861	CDD:275380
		LRRCT	872..920	CDD:214507
		EGF	935..966	CDD:278437
		EGF_CA	971..1007	CDD:238011
		EGF_CA	1009..1045	CDD:238011
		EGF_CA	1055..1086	CDD:238011
		EGF_CA	1088..1124	CDD:238011
		Laminin_G_1	1204..1335	CDD:278483
		CT	1435..1504	CDD:214482
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443104
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930