DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5096 and CG4168

DIOPT Version :9

Sequence 1:	NP_723576.1	Gene:	CG5096 / 34410	FlyBaseID:	FBgn0032235	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_001285953.1	Gene:	CG4168 / 34889	FlyBaseID:	FBgn0028888	Length:	1330	Species:	Drosophila melanogaster

Alignment Length:	506	Identity:	113/506 - (22%)
Similarity:	182/506 - (35%)	Gaps:	168/506 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 LDCSEKLQDWLSAEDWEDLTNGNVVFKTINLEHNNLTSVPILPKYDVE---NLYLANNQIDSISV 120
            :|.|....:.|.|:.:..|.:    .:|:||:.|.|.::.....:::|   .|.|:.|::.:||.
  Fly   643 IDLSYNGLERLEAQTFHSLGD----LQTLNLQSNRLRTIARHAFHNLEFLRYLDLSYNRLVNISH 703

  Fly   121 GAFQNLTELVTLDLSHNRL----------TSKVLVP--------------------------DVF 149
            |||..|..|..|||.||:|          .|....|                          |:.
  Fly   704 GAFTVLPNLAALDLMHNQLCSLSLKSFLYVSNTTTPLRLNVSHNHIASFYDELSSYMYIYQLDIS 768

  Fly   150 KGPFTVQD-FESLEN-LKTLNLGYNDLHSLDADLFEHIPHIEELVLCSNSFHVIDQLSETAISGL 212
            ....|..| |.:|.| |:.|||.:|.|.||.:..|..:..:|.|.:..|:   :..|...:..||
  Fly   769 HNHVTKSDSFTNLANTLRFLNLAHNQLGSLQSHAFGDLEFLEILNVAHNN---LTSLRRRSFQGL 830

  Fly   213 QSLKILDVSYMEIDDLPDTILHGPRDLEIFIAAGNLFNQLPKALKYATNLTSLVLNENPIENLIG 277
            .||:.||:|:.::|.|........|.|.|.....|....||:.:...|.|..|.:.||.:
  Fly   831 NSLQELDLSHNQLDQLQVEQFSNLRKLRILRINSNRLRALPREVFMNTRLEFLDIAENQL----- 890

  Fly   278 DNVFP-PL----------TKLTHLSMTFMSK--------LYKIG----------PGAFSELQSLT 313
             :|:| |.          .:::|.::.::..        ||.|.          ...||.|.:||
  Fly   891 -SVWPVPAFTDIGFTLRSIQMSHNNLEYLDASMFINSQFLYDISLARNRITILPDNTFSFLNNLT 954

  Fly   314 ELILSDNKL----LNEIDEEALSKNVTGGQYLDYPPLEKVYLNNCNVSTLP-------------- 360
            .|.||.|.|    |.|:             ::..|.|.|:.|::..:..||
  Fly   955 NLDLSQNPLVTTNLREV-------------FVHTPRLRKLSLHHMGLYVLPPLKLPLLSYLDVSG 1006

  Fly   361 ---------------KELLVRWDKL--------------KALDLRFNPWNCDESNDFL------- 389
                           :.:.|..:||              :.|||..||......:|..
  Fly  1007 NYLQELSPLGSLRHLRHVNVSHNKLTNASCAAEHLPPSVRVLDLAHNPLRRITLHDLASLRHLAE 1071

  Fly   390 INVLIDRINKTTPVLAKDVKCGGPNKLNDVTLLRV--ANEHMIESSTGSLI 438
            :|:|             |||...|...:.:..||.  |:.|   ::.|.::
  Fly  1072 LNIL-------------DVKVTNPQAFSKLRSLRKLHASSH---ANLGEIV 1106

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5096	NP_723576.1	LRR_RI	69..378	CDD:238064	97/425 (23%)
		leucine-rich repeat	85..104	CDD:275380	5/18 (28%)
		LRR_8	105..174	CDD:290566	30/109 (28%)
		leucine-rich repeat	105..128	CDD:275380	10/25 (40%)
		leucine-rich repeat	129..163	CDD:275380	14/70 (20%)
		LRR_8	163..222	CDD:290566	20/59 (34%)
		leucine-rich repeat	164..187	CDD:275380	9/22 (41%)
		leucine-rich repeat	188..214	CDD:275380	6/25 (24%)
		leucine-rich repeat	215..238	CDD:275380	6/22 (27%)
		leucine-rich repeat	239..261	CDD:275380	5/21 (24%)
		LRR_8	260..322	CDD:290566	21/90 (23%)
		leucine-rich repeat	262..286	CDD:275380	7/34 (21%)
		leucine-rich repeat	287..311	CDD:275380	7/41 (17%)
		leucine-rich repeat	346..369	CDD:275380	6/51 (12%)
		leucine-rich repeat	370..388	CDD:275380	6/31 (19%)
CG4168	NP_001285953.1	leucine-rich repeat	99..118	CDD:275380
		LRR_8	121..181	CDD:290566
		LRR_RI	122..350	CDD:238064
		leucine-rich repeat	122..146	CDD:275380
		leucine-rich repeat	147..170	CDD:275380
		leucine-rich repeat	171..194	CDD:275380
		leucine-rich repeat	195..214	CDD:275380
		leucine-rich repeat	215..236	CDD:275380
		LRR_8	265..322	CDD:290566
		leucine-rich repeat	266..287	CDD:275380
		leucine-rich repeat	288..311	CDD:275380
		leucine-rich repeat	312..338	CDD:275380
		LRR_RI	315..546	CDD:238064
		leucine-rich repeat	339..365	CDD:275380
		LRR_8	365..424	CDD:290566
		leucine-rich repeat	366..388	CDD:275380
		leucine-rich repeat	389..412	CDD:275380
		LRR_8	413..470	CDD:290566
		leucine-rich repeat	414..436	CDD:275380
		leucine-rich repeat	437..459	CDD:275380
		leucine-rich repeat	460..483	CDD:275380
		LRR_8	482..545	CDD:290566
		leucine-rich repeat	484..510	CDD:275380
		leucine-rich repeat	511..534	CDD:275380
		leucine-rich repeat	535..589	CDD:275380
		LRR_RI	588..891	CDD:238064	68/260 (26%)
		LRR_8	588..650	CDD:290566	2/6 (33%)
		leucine-rich repeat	590..613	CDD:275380
		leucine-rich repeat	614..639	CDD:275380
		LRR_8	638..698	CDD:290566	14/58 (24%)
		leucine-rich repeat	640..663	CDD:275380	5/19 (26%)
		leucine-rich repeat	664..687	CDD:275380	5/22 (23%)
		LRR_8	688..749	CDD:290566	18/60 (30%)
		leucine-rich repeat	688..711	CDD:275380	9/22 (41%)
		leucine-rich repeat	712..735	CDD:275380	7/22 (32%)
		leucine-rich repeat	740..783	CDD:275380	5/42 (12%)
		LRR_8	784..843	CDD:290566	20/61 (33%)
		leucine-rich repeat	785..808	CDD:275380	9/22 (41%)
		leucine-rich repeat	809..832	CDD:275380	6/25 (24%)
		LRR_RI	<827..1053	CDD:238064	51/244 (21%)
		LRR_8	832..890	CDD:290566	18/57 (32%)
		leucine-rich repeat	833..856	CDD:275380	6/22 (27%)
		leucine-rich repeat	857..879	CDD:275380	5/21 (24%)
		leucine-rich repeat	880..900	CDD:275380	7/25 (28%)
		LRR_8	904..963	CDD:290566	13/58 (22%)
		leucine-rich repeat	905..928	CDD:275380	1/22 (5%)
		leucine-rich repeat	929..952	CDD:275380	6/22 (27%)
		leucine-rich repeat	953..977	CDD:275380	9/36 (25%)
		leucine-rich repeat	978..1020	CDD:275380	5/41 (12%)
		LRR_8	1019..1074	CDD:290566	9/54 (17%)
		leucine-rich repeat	1045..1068	CDD:275380	6/22 (27%)
		leucine-rich repeat	1069..1090	CDD:275380	6/33 (18%)
		leucine-rich repeat	1091..1114	CDD:275380	5/19 (26%)
		leucine-rich repeat	1115..1161	CDD:275380
		leucine-rich repeat	1162..1190	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010