DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5096 and CG42346

DIOPT Version :9

Sequence 1:	NP_723576.1	Gene:	CG5096 / 34410	FlyBaseID:	FBgn0032235	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_001036303.2	Gene:	CG42346 / 3355160	FlyBaseID:	FBgn0259677	Length:	1817	Species:	Drosophila melanogaster

Alignment Length:	510	Identity:	125/510 - (24%)
Similarity:	201/510 - (39%)	Gaps:	151/510 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 TETPKEKIKVI---DSKLCK-KCNCYIDT----NLLDCSEKLQDWLSAEDWEDLTNGNVVFKTIN 88
            |.:.::|::::   |::|.: :.:.:.||    .|.....|::| :..:.:.:|    ::.:.::
  Fly   742 TFSRQQKVQIMWLKDNQLTRVERSFFADTPQLGRLYLSDNKIRD-IEKDTFVNL----LLLQFLD 801

  Fly    89 LEHNNLTSVP---ILPKYDVENLYLANNQIDSISVGAFQNLTELVTLDLSHNRLTSKVLVPDVFK 150
            |..|.|..:.   ..|..|:|.|.||.|.|::|...||..|..|.:||||||.|..  |..|:|.
  Fly   802 LSGNQLRQLRRDYFAPLQDLEELSLARNHIEAIEGYAFAKLKNLKSLDLSHNPLVQ--LTRDIFS 864

  Fly   151 GPFTVQD---------------FESLENLKTLNLGYNDLHSLDADLFEHIPHIEELVLCSNSFHV 200
            ..|.:..               |:||.||..|||..|.|:..|....: ||::..|:|..|:|..
  Fly   865 NEFPLNSLNLGNCSLRKLEQHAFKSLTNLNELNLERNQLNPADIQTLD-IPNLRRLLLSHNNFSY 928

  Fly   201 IDQLSETA--ISGLQSLKILDVSYMEIDDLPDTILHGPRDLEIFIAAGNLFNQLPKALKYATNLT 263
            ...:...|  :..|:||:.|.:|...:..:||.:.           |.|            |||.
  Fly   929 AGSVGIMAGMLDRLRSLQQLSMSNCSLGQIPDLLF-----------AKN------------TNLV 970

  Fly   264 SLVLNENPIENL-----IGDNVFP-------PLTKLTHLSMTFMSKLYKIGPGAFSELQS----- 311
            .|.|.:|.:..:     .|.|||.       .|:...|:::..:|.|..:.. |.::|.|
  Fly   971 RLDLCDNRLTQINRNIFSGLNVFKELRLCRNELSDFPHIALYNLSTLESLDL-ARNQLASIDFFK 1034

  Fly   312 ------LTELILSDNKL----------LNEIDEEALSKNVTGGQYLDYPP--------LEKVYLN 352
                  |.:|||.|||:          |.::|    |.:::|...|..|.        |:||:|:
  Fly  1035 LSGTLNLRQLILRDNKITALSGFNAVNLTQLD----SVDLSGNLLLSLPANFLRHSINLQKVHLS 1095

  Fly   353 NCNVSTLPKELL--VRWDKLKALDLRFNPWN------------------CD------ESNDF--- 388
            |.....:|...|  |...:|..|:|..||.|                  |.      .|.||
  Fly  1096 NNRFLQIPSSALSDVSIPRLSWLNLTGNPINRIYTVKEERYPYLKELYICQTNLSILTSKDFEAF 1160

  Fly   389 -------LINVLIDRIN-----KTTPVLAKDVKCG-----GPNKLNDVTLLRVAN 426
                   |:|..|.||:     ..|.:|..|:...     ...:|..:.|||..|
  Fly  1161 QALQHLHLVNNRITRISPGAFKSLTNLLTLDLSVNELEMLPKERLQGLRLLRFLN 1215

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5096	NP_723576.1	LRR_RI	69..378	CDD:238064	96/371 (26%)
		leucine-rich repeat	85..104	CDD:275380	4/21 (19%)
		LRR_8	105..174	CDD:290566	31/83 (37%)
		leucine-rich repeat	105..128	CDD:275380	10/22 (45%)
		leucine-rich repeat	129..163	CDD:275380	15/48 (31%)
		LRR_8	163..222	CDD:290566	19/60 (32%)
		leucine-rich repeat	164..187	CDD:275380	8/22 (36%)
		leucine-rich repeat	188..214	CDD:275380	6/27 (22%)
		leucine-rich repeat	215..238	CDD:275380	5/22 (23%)
		leucine-rich repeat	239..261	CDD:275380	2/21 (10%)
		LRR_8	260..322	CDD:290566	23/84 (27%)
		leucine-rich repeat	262..286	CDD:275380	9/35 (26%)
		leucine-rich repeat	287..311	CDD:275380	5/23 (22%)
		leucine-rich repeat	346..369	CDD:275380	8/24 (33%)
		leucine-rich repeat	370..388	CDD:275380	8/41 (20%)
CG42346	NP_001036303.2	leucine-rich repeat	303..325	CDD:275380
		LRR_8	325..384	CDD:290566
		leucine-rich repeat	327..350	CDD:275380
		leucine-rich repeat	351..461	CDD:275380
		LRR_8	373..433	CDD:290566
		LRR_RI	397..648	CDD:238064
		leucine-rich repeat	399..422	CDD:275380
		leucine-rich repeat	462..485	CDD:275380
		LRR_8	465..520	CDD:290566
		leucine-rich repeat	486..509	CDD:275380
		LRR_8	508..567	CDD:290566
		leucine-rich repeat	510..533	CDD:275380
		LRR_RI	527..785	CDD:238064	8/42 (19%)
		leucine-rich repeat	534..556	CDD:275380
		LRR_8	555..613	CDD:290566
		leucine-rich repeat	557..580	CDD:275380
		leucine-rich repeat	581..604	CDD:275380
		LRR_8	604..663	CDD:290566
		leucine-rich repeat	605..628	CDD:275380
		leucine-rich repeat	629..652	CDD:275380
		LRR_8	652..711	CDD:290566
		leucine-rich repeat	653..676	CDD:275380
		leucine-rich repeat	677..700	CDD:275380
		leucine-rich repeat	701..748	CDD:275380	1/5 (20%)
		leucine-rich repeat	725..736	CDD:275378
		leucine-rich repeat	749..772	CDD:275380	4/22 (18%)
		LRR_8	771..831	CDD:290566	14/64 (22%)
		leucine-rich repeat	773..793	CDD:275380	3/20 (15%)
		LRR_RI	804..1076	CDD:238064	81/302 (27%)
		LRR_8	821..903	CDD:290566	31/83 (37%)
		leucine-rich repeat	821..844	CDD:275380	10/22 (45%)
		leucine-rich repeat	845..868	CDD:275380	11/24 (46%)
		leucine-rich repeat	869..892	CDD:275380	3/22 (14%)
		leucine-rich repeat	893..915	CDD:275380	8/22 (36%)
		leucine-rich repeat	916..944	CDD:275380	6/27 (22%)
		leucine-rich repeat	945..968	CDD:275380	7/45 (16%)
		LRR_8	967..1027	CDD:290566	15/60 (25%)
		leucine-rich repeat	969..992	CDD:275380	5/22 (23%)
		leucine-rich repeat	993..1014	CDD:275380	3/20 (15%)
		LRR_8	1015..1075	CDD:290566	16/64 (25%)
		leucine-rich repeat	1017..1040	CDD:275380	4/23 (17%)
		leucine-rich repeat	1041..1064	CDD:275380	8/22 (36%)
		LRR_RI	<1047..1244	CDD:238064	40/173 (23%)
		LRR_8	1063..1125	CDD:290566	17/65 (26%)
		leucine-rich repeat	1089..1114	CDD:275380	8/24 (33%)
		leucine-rich repeat	1115..1162	CDD:275380	10/46 (22%)
		LRR_8	1163..1219	CDD:290566	13/53 (25%)
		leucine-rich repeat	1163..1186	CDD:275380	5/22 (23%)
		leucine-rich repeat	1187..1210	CDD:275380	3/22 (14%)
		leucine-rich repeat	1211..1233	CDD:275380	3/5 (60%)
		leucine-rich repeat	1234..1257	CDD:275380
		LRR_8	1235..1292	CDD:290566
		leucine-rich repeat	1258..1279	CDD:275380
		leucine-rich repeat	1282..1306	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45617
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100